{"id":50056,"date":"2026-09-14T13:01:07","date_gmt":"2026-09-14T17:01:07","guid":{"rendered":"https:\/\/www.squawka.com\/us\/?post_type=nfl-news&#038;p=50056"},"modified":"2026-09-14T13:01:07","modified_gmt":"2026-09-14T17:01:07","slug":"dolphins-vs-49ers-prediction-picks-odds-week-2","status":"publish","type":"nfl-news","link":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/dolphins-vs-49ers-prediction-picks-odds-week-2\/","title":{"rendered":"Dolphins vs 49ers Prediction, Picks &#038; Odds: Week 2"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Our <strong>Dolphins vs 49ers prediction<\/strong> is the most one-sided call of the late window. Squawka Signal&#8217;s live read on this game, including where the value sits, updates on this page through the week.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The <a href=\"https:\/\/www.squawka.com\/us\/nfl\/teams\/san-francisco-49ers\/\">San Francisco 49ers<\/a> beat the Rams 27-7 in Melbourne with three passing touchdowns. The <a href=\"https:\/\/www.squawka.com\/us\/nfl\/teams\/miami-dolphins\/\">Miami Dolphins<\/a> lost 27-13 at Las Vegas, where Malik Willis was sacked five times. Consequently the gap between these two is as wide as any on the card.<\/p>\n\n\n\n<!-- SQ_NFL_SIG_START -->\n\n<style>\n.sq-nsig{position:relative;overflow:hidden;border-radius:18px;margin:28px 0;isolation:isolate;background:radial-gradient(70% 90% at 18% 0%,rgba(47,230,201,.14) 0%,rgba(47,230,201,0) 60%),linear-gradient(135deg,#0a2540 0%,#06182b 60%,#040f1d 100%);box-shadow:0 18px 44px rgba(4,15,29,.5);font-family:'Bricolage 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a{color:#2FE6C9;text-decoration:underline}\n@media(max-width:560px){.sq-nsig__inner{padding:22px 16px}.sq-nsig__cmp{gap:10px}.sq-nsig__verd{min-width:0}.sq-nsig__name{font-size:14px}}\n.sq-nsig__geo-r{position:absolute;width:0;height:0;opacity:0;pointer-events:none}\n.sq-nsig__geo-tabs{display:inline-flex;border:1px solid rgba(47,230,201,.4);border-radius:999px;overflow:hidden;margin:0 0 14px}\n.sq-nsig__geo-tab{cursor:pointer;padding:6px 15px;font-size:11px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:rgba(232,240,247,.6)}\n.sq-nsig__geo-a{display:contents}.sq-nsig__geo-b{display:none}\n.sq-nsig__geo-r--a:checked~.sq-nsig__geo-tabs .sq-nsig__geo-tab--a,.sq-nsig__geo-r--b:checked~.sq-nsig__geo-tabs .sq-nsig__geo-tab--b{background:#2FE6C9;color:#04121f}\n.sq-nsig__geo-r--b:checked~.sq-nsig__cards .sq-nsig__geo-a,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-a{display:none}\n.sq-nsig__geo-r--b:checked~.sq-nsig__cards .sq-nsig__geo-b,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-b{display:contents}\n<\/style>\n<div class=\"sq-nsig\"><div class=\"sq-nsig__inner\"><span class=\"sq-nsig__tag\"><span class=\"dot\"><\/span>Squawka Signal &middot; Model vs market<\/span><h3 class=\"sq-nsig__title\">Miami Dolphins @ San Francisco 49ers<\/h3><p class=\"sq-nsig__meta\">Week 2 &middot; Sun Sep 20, 4:25 PM ET. Our Signal model makes the <b>San Francisco 49ers<\/b> favorites by about <b>8<\/b> points, a 78% win probability.<\/p><div class=\"sq-nsig__cards\"><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/MIA.png\" alt=\"MIA\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">Miami Dolphins<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Squawka<\/span><span class=\"sq-nsig__cmp-sig\">22%<\/span><\/span><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Market<\/span><span class=\"sq-nsig__cmp-mkt\">12%<\/span><\/span><span class=\"sq-nsig__verd sq-nsig__verd--val\">&#9650; Strong value<\/span><\/span><\/div><\/div><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"SF\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">San Francisco 49ers<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Squawka<\/span><span class=\"sq-nsig__cmp-sig\">78%<\/span><\/span><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Market<\/span><span class=\"sq-nsig__cmp-mkt\">88%<\/span><\/span><span class=\"sq-nsig__verd sq-nsig__verd--over\">&#9660; Overpriced<\/span><\/span><\/div><\/div><\/div><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Projected line<\/span><span class=\"sq-nsig__mc-v\">San Francisco 49ers -8<\/span><\/div><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Against the spread<\/span><span class=\"sq-nsig__mc-v\">Miami Dolphins +13 &mdash; model San Francisco 49ers -8 vs market San Francisco 49ers -13<\/span><\/div><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Value<\/span><span class=\"sq-nsig__mc-v\">Miami Dolphins &mdash; model 22% vs market 12%<\/span><\/div><div class=\"sq-nsig__cta-row\" style=\"margin-top:14px\"><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/kalshi?q=us-all-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">Kalshi<\/a><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/polymarket?q=us-sg1-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">Polymarket<\/a><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/prophet-x?q=us-sg1-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">ProphetX<\/a><\/div><p class=\"sq-nsig__foot\">Squawka Signal is our model&#8217;s read against devigged market prices, updated after every result &mdash; not betting advice. <a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/nfl-signal-methodology\/\">How the NFL Signal works<\/a>. 21+. 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palette matched to the injected sq-nsig Signal units *\/\n.sqp{--cy:#2FE6C9;--val:#38D97A;--ovr:#FF6A5A;--fair:#FFC24B;--tx:#e8f0f7;--mut:rgba(232,240,247,.60);--line:rgba(255,255,255,.10);--gold:#FFC24B;position:relative;overflow:hidden;font-family:'Bricolage Grotesque',system-ui,-apple-system,Segoe UI,Roboto,sans-serif;color:var(--tx);max-width:960px;margin:14px auto 26px;border-radius:14px;background:linear-gradient(135deg,#0a2540 0%,#06182b 62%,#04121f 100%);box-shadow:0 14px 36px rgba(4,18,31,.34)}\n.sqp *{box-sizing:border-box}\n.sqp__wrap{padding:22px 26px 20px}\n.sqp__kick{display:inline-flex;align-items:center;gap:8px;font-size:11px;font-weight:800;letter-spacing:.14em;text-transform:uppercase;color:var(--cy)}\n.sqp__kick::before{content:'';width:7px;height:7px;border-radius:50%;background:var(--cy);box-shadow:0 0 9px 1px var(--cy)}\n.sqp__ttl{font-size:24px;font-weight:800;letter-spacing:-.3px;line-height:1.14;margin:12px 0 0;color:var(--tx)}\n.sqp__sub{margin:7px 0 0;font-size:14.5px;line-height:1.5;color:var(--mut);max-width:70ch}\n.sqp__crests{display:flex;align-items:center;gap:10px;margin-top:14px}\n.sqp__crests img{width:28px;height:28px;display:block}\n.sqp__at{font-size:12px;font-weight:700;color:var(--mut);letter-spacing:.1em}\n.sqp__h3{margin:20px 0 0;font-size:10.5px;font-weight:800;letter-spacing:.16em;text-transform:uppercase;color:var(--cy)}\n.sqp__list{margin-top:12px;border-top:1px solid var(--line)}\n.sqp__row{display:grid;grid-template-columns:1fr 126px;gap:14px;align-items:center;padding:14px 2px;border-bottom:1px solid var(--line)}\n.sqp__mkt{display:block;font-size:10px;font-weight:800;letter-spacing:.13em;text-transform:uppercase;color:var(--cy);margin-bottom:4px}\n.sqp__pk{font-size:15.5px;font-weight:800;line-height:1.25;color:var(--tx)}\n.sqp__top{display:inline-block;vertical-align:middle;margin-left:8px;font-size:9.5px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:#3a2c00;background:var(--gold);padding:3px 7px;border-radius:5px}\n.sqp__why{display:block;margin-top:5px;font-size:13.5px;line-height:1.5;color:var(--mut)}\n.sqp__pr{text-align:center}\n.sqp__val{display:block;font-size:23px;font-weight:800;color:var(--cy);line-height:1;text-decoration:none}\na.sqp__val:hover{text-decoration:underline}\n.sqp__stars{display:block;font-size:15px;line-height:1;letter-spacing:1px;color:var(--gold)}\n.sqp__stars .d{opacity:.24}\n.sqp__lab{display:block;font-size:10px;letter-spacing:.06em;text-transform:uppercase;color:var(--mut);margin-top:4px}\n.sqp__verd{display:inline-block;margin-top:6px;font-size:10.5px;font-weight:800;letter-spacing:.04em;padding:2px 7px;border-radius:5px}\n.sqp__verd--val{color:var(--val);background:rgba(56,217,122,.12)}\n.sqp__verd--ovr{color:var(--ovr);background:rgba(255,106,90,.12)}\n.sqp__verd--fair{color:var(--fair);background:rgba(255,194,75,.12)}\n.sqp__approach{margin:14px 0 0;font-size:13.5px;line-height:1.55;color:var(--tx)}\n.sqp__foot{margin:16px 0 0;padding-top:13px;border-top:1px solid var(--line);font-size:11.5px;line-height:1.55;color:rgba(232,240,247,.5)}\n.sqp__foot a{color:var(--cy);font-weight:700;text-decoration:none;border-bottom:1px solid rgba(47,230,201,.35)}\n@media(max-width:640px){\n.sqp__wrap{padding:18px 15px 16px}\n.sqp__ttl{font-size:20px}\n.sqp__row{grid-template-columns:1fr 100px;gap:10px}\n.sqp__val{font-size:20px}\n}\n<\/style>\n<div class=\"sqp\" id=\"sqp-miasf\">\n<div class=\"sqp__wrap\">\n<span class=\"sqp__kick\">Week 1 &middot; Editorial pick<\/span>\n<h2 class=\"sqp__ttl\">Dolphins vs 49ers: our editor&#8217;s props<\/h2>\n<p class=\"sqp__sub\">Two editorial calls to sit alongside the live Signal numbers on this page.<\/p>\n<div class=\"sqp__crests\">\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/MIA.png\" alt=\"Dolphins\" loading=\"lazy\" width=\"28\" height=\"28\">\n<span class=\"sqp__at\">AT<\/span>\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"49ers\" loading=\"lazy\" width=\"28\" height=\"28\">\n<\/div>\n<h3 class=\"sqp__h3\">Our props<\/h3>\n<div class=\"sqp__list\">\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"Brock Purdy 2+ passing touchdowns\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">Brock Purdy 2+ passing touchdowns<\/span><span class=\"sqp__why\">Purdy threw three against the Rams at a 105.6 rating. Miami conceded three touchdown passes to Kirk Cousins in Week 1.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 4 of 5\">&#9733;&#9733;&#9733;&#9733;<span class=\"d\">&#9733;<\/span><\/span><span class=\"sqp__lab\">confidence<\/span><\/div>\n<\/div>\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"Miami under 20.5 points\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">Miami under 20.5 points<\/span><span class=\"sqp__why\">The Dolphins scored 13 at Las Vegas on 20% third-down conversion. San Francisco conceded seven points to the Rams.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 3 of 5\">&#9733;&#9733;&#9733;<span class=\"d\">&#9733;&#9733;<\/span><\/span><span class=\"sqp__lab\">confidence<\/span><\/div>\n<\/div>\n<\/div>\n<p class=\"sqp__foot\">An editorial call, not a Signal model output. 21+. Gambling Problem? Call 1-800-GAMBLER.<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Dolphins vs 49ers: 2026 form so far<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A 1-0 team that won by 20 against a 0-1 team that could not protect its quarterback. The table is not subtle.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th>2026 season to date<\/th>\n<th class=\"has-text-align-center\" data-align=\"center\">Dolphins<\/th>\n<th class=\"has-text-align-center\" data-align=\"center\">49ers<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Record<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">0-1<\/td><td class=\"has-text-align-center\" data-align=\"center\">1-0<\/td><\/tr>\n<tr><td><strong>Points for<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">13<\/td><td class=\"has-text-align-center\" data-align=\"center\">27<\/td><\/tr>\n<tr><td><strong>Points against<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">27<\/td><td class=\"has-text-align-center\" data-align=\"center\">7<\/td><\/tr>\n<tr><td><strong>Point differential<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">-14<\/td><td class=\"has-text-align-center\" data-align=\"center\">+20<\/td><\/tr>\n<tr><td><strong>Total yards<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">259<\/td><td class=\"has-text-align-center\" data-align=\"center\">379<\/td><\/tr>\n<tr><td><strong>Yards per play<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">5.2<\/td><td class=\"has-text-align-center\" data-align=\"center\">5.9<\/td><\/tr>\n<tr><td><strong>Turnovers<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">2<\/td><td class=\"has-text-align-center\" data-align=\"center\">1<\/td><\/tr>\n<tr><td><strong>Third-down offense<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">20.0%<\/td><td class=\"has-text-align-center\" data-align=\"center\">58.3%<\/td><\/tr>\n<tr><td><strong>Red-zone offense<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">33.3%<\/td><td class=\"has-text-align-center\" data-align=\"center\">66.7%<\/td><\/tr>\n<tr><td><strong>Sacks recorded<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">0<\/td><td class=\"has-text-align-center\" data-align=\"center\">0<\/td><\/tr>\n<tr><td><strong>Opponent passer rating<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">88.2<\/td><td class=\"has-text-align-center\" data-align=\"center\">62.8<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">San Francisco converted 58.3% of third downs and held the ball for almost 34 minutes. Miami managed 20% and 25 minutes, and were sacked five times.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Dolphins vs 49ers injury report and team news<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Malik Willis completed 15 of 27 for Miami at a 66.9 rating and was sacked five times. De&#8217;Von Achane carried 11 times for 36 yards.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This section updates as soon as the Out, Doubtful and Questionable tags land.<\/p>\n\n\n\n<!-- SQ_NFL_INJ_START -->\n\n<style>\n.sq-ninj{border:1px solid #123f5c;border-radius:14px;overflow:hidden;margin:24px 0;font-family:'Bricolage Grotesque',system-ui,-apple-system,sans-serif;background:#0a2540;color:#e8f0f7}\n.sq-ninj__head{display:flex;align-items:baseline;justify-content:space-between;gap:10px;padding:13px 16px;background:#06182b;font-weight:800;font-size:13px;letter-spacing:.4px;text-transform:uppercase;color:#fff;border-bottom:1px solid #123f5c}\n.sq-ninj__head span{font-size:11px;font-weight:600;letter-spacing:0;text-transform:none;color:rgba(232,240,247,.6)}\n.sq-ninj__cols{display:flex;flex-wrap:wrap}\n.sq-ninj__col{flex:1 1 260px;padding:14px 16px}\n.sq-ninj__col+.sq-ninj__col{border-left:1px solid #123f5c}\n.sq-ninj__team{display:flex;align-items:center;gap:9px;font-weight:800;font-size:14px;color:#fff;margin-bottom:10px}\n.sq-ninj__team img{width:24px;height:24px;object-fit:contain}\n.sq-ninj__row{display:flex;align-items:center;gap:8px;padding:6px 0;border-top:1px solid rgba(255,255,255,.06);font-size:13.5px}\n.sq-ninj__nm{flex:1;min-width:0;color:#fff;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}\n.sq-ninj__pos{flex:0 0 auto;color:rgba(232,240,247,.55);font-size:11px;font-weight:700}\n.sq-ninj__st{flex:0 0 auto;font-size:10.5px;font-weight:800;letter-spacing:.04em;text-transform:uppercase;padding:3px 9px;border-radius:999px}\n.sq-ninj__st--out{background:rgba(255,106,90,.16);color:#FF6A5A}\n.sq-ninj__st--doubt{background:rgba(255,194,75,.16);color:#FFC24B}\n.sq-ninj__st--ques{background:rgba(232,240,247,.1);color:rgba(232,240,247,.8)}\n.sq-ninj__none{font-size:13px;color:rgba(232,240,247,.55);padding:4px 0}\n@media(max-width:520px){.sq-ninj__col+.sq-ninj__col{border-left:0;border-top:1px solid #123f5c}}\n<\/style><div class=\"sq-ninj\"><div class=\"sq-ninj__head\">Injury report &middot; Week 2<span>Official game-status report &mdash; updates through the week<\/span><\/div><div class=\"sq-ninj__cols\"><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/MIA.png\" alt=\"MIA\" loading=\"lazy\" width=\"24\" height=\"24\">Miami Dolphins<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><\/div><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"SF\" loading=\"lazy\" width=\"24\" height=\"24\">San Francisco 49ers<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><\/div><\/div><\/div>\n\n<!-- SQ_NFL_INJ_END -->\n\n\n\n<h2 class=\"wp-block-heading\">Where Dolphins vs 49ers is decided<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Miami&#8217;s protection is the immediate problem. Five sacks conceded at Las Vegas, against a San Francisco front that did not need one to win by 20.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Brock Purdy threw three touchdowns from 34 attempts and Christian McCaffrey averaged 6.8 a carry. San Francisco did not have to force anything.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Miami&#8217;s defense did force two interceptions at Las Vegas, so there is a route to staying in it. Nevertheless they conceded three touchdown passes in the same game.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Players to watch<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Malik Willis (MIA, QB):<\/strong> 220 yards, no touchdowns and five sacks taken at Las Vegas.<\/li>\n<li><strong>De&#8217;Von Achane (MIA, RB):<\/strong> 11 carries for 36 yards in the opener.<\/li>\n<li><strong>Brock Purdy (SF, QB):<\/strong> Three touchdown passes at a 105.6 rating against the Rams.<\/li>\n<li><strong>Christian McCaffrey (SF, RB):<\/strong> Ten carries for 68 yards at 6.8 a carry.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to watch Dolphins vs 49ers<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The game kicks off at 4:25 PM ET on Sunday, September 20 at Levi&#8217;s Stadium in Santa Clara. FOX carries it. It sits in the later Sunday afternoon window.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr><th>Detail<\/th><th>Dolphins vs 49ers<\/th><\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Date<\/strong><\/td><td>Sunday, September 20, 2026<\/td><\/tr>\n<tr><td><strong>Kickoff<\/strong><\/td><td>4:25 PM ET \/ 3:25 PM CT \/ 1:25 PM PT<\/td><\/tr>\n<tr><td><strong>Venue<\/strong><\/td><td>Levi&#8217;s Stadium, Santa Clara, CA<\/td><\/tr>\n<tr><td><strong>TV<\/strong><\/td><td>FOX<\/td><\/tr>\n<tr><td><strong>Live stream<\/strong><\/td><td>NFL Game Pass (DAZN)<\/td><\/tr>\n<tr><td><strong>Week<\/strong><\/td><td>Week 2, 2026 NFL season<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Dolphins vs 49ers prediction and score projection<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Our <strong>Dolphins vs 49ers prediction<\/strong> is a San Francisco win, 30-13. The 49ers are better in every phase, and Miami cannot keep their quarterback upright.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For the model&#8217;s read rather than ours, the live number updates on this page.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Every fixture in the round is covered across our <a href=\"\/us\/nfl\/\">NFL hub<\/a>, and Signal rates <a href=\"\/us\/nfl\/picks\/\">every Week 2 game<\/a> the same way.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Dolphins vs 49ers FAQ<\/h2>\n\n\n\n<div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-miasf-1\"><strong class=\"schema-faq-question\">Who is favored to win, the Dolphins or the 49ers?<\/strong> <p class=\"schema-faq-answer\">San Francisco, clearly. The 49ers won their opener 27-7; Miami lost 27-13 and conceded five sacks.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-miasf-2\"><strong class=\"schema-faq-question\">What time is Dolphins vs 49ers?<\/strong> <p class=\"schema-faq-answer\">4:25 PM ET on Sunday, September 20, which is 3:25 PM CT and 1:25 PM PT.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-miasf-3\"><strong class=\"schema-faq-question\">What channel is Dolphins vs 49ers on?<\/strong> <p class=\"schema-faq-answer\">FOX has the game in the United States.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-miasf-4\"><strong class=\"schema-faq-question\">How did each team do in Week 1?<\/strong> <p class=\"schema-faq-answer\">San Francisco beat the Rams 27-7 in Melbourne. Miami lost 27-13 at Las Vegas.<\/p><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>21+ | Gambling Problem? Call 1-800-GAMBLER | Signal probabilities and odds approximate at time of writing and subject to change<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our Dolphins vs 49ers prediction is the most one-sided call of the late window. Squawka Signal&#8217;s live read on this game, including where the value sits, updates on this page through the week. The San Francisco 49ers beat the Rams 27-7 in Melbourne with three passing touchdowns. The Miami Dolphins lost 27-13 at Las Vegas,&#8230;<\/p>\n","protected":false},"author":394,"featured_media":50055,"menu_order":0,"template":"","meta":{"_acf_changed":false,"_yoast_wpseo_focuskw":"dolphins vs 49ers prediction","_yoast_wpseo_title":"Dolphins vs 49ers Prediction, Picks & Odds: Week 2 | Squawka","_yoast_wpseo_metadesc":"Our Dolphins vs 49ers prediction, picks and odds for Week 2 in Santa Clara. 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