{"id":49974,"date":"2026-09-14T13:01:10","date_gmt":"2026-09-14T17:01:10","guid":{"rendered":"https:\/\/www.squawka.com\/us\/?post_type=nfl-news&#038;p=49974"},"modified":"2026-09-14T13:01:10","modified_gmt":"2026-09-14T17:01:10","slug":"lions-vs-bills-prediction-picks-odds-week-2","status":"publish","type":"nfl-news","link":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/lions-vs-bills-prediction-picks-odds-week-2\/","title":{"rendered":"Lions vs Bills Prediction, Picks &#038; Odds: Week 2"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Our <strong>Lions vs Bills prediction<\/strong> leans to Buffalo in a meeting of two 1-0 teams who won their openers in opposite ways. Thursday night is also the first regular-season game at the new Highmark Stadium. Squawka Signal&#8217;s live read on this game, including where the value sits, updates on this page through the week.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The <a href=\"https:\/\/www.squawka.com\/us\/nfl\/teams\/detroit-lions\/\">Detroit Lions<\/a> needed almost 37 minutes of possession and 33 carries to edge New Orleans 31-30. The <a href=\"https:\/\/www.squawka.com\/us\/nfl\/teams\/buffalo-bills\/\">Buffalo Bills<\/a> needed 52 plays and under 24 minutes to put 36 on Houston. Consequently the question is whether Detroit can dictate the terms a second week running.<\/p>\n\n\n\n<!-- SQ_NFL_SIG_START -->\n\n<style>\n.sq-nsig{position:relative;overflow:hidden;border-radius:18px;margin:28px 0;isolation:isolate;background:radial-gradient(70% 90% at 18% 0%,rgba(47,230,201,.14) 0%,rgba(47,230,201,0) 60%),linear-gradient(135deg,#0a2540 0%,#06182b 60%,#040f1d 100%);box-shadow:0 18px 44px rgba(4,15,29,.5);font-family:'Bricolage 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a{color:#2FE6C9;text-decoration:underline}\n@media(max-width:560px){.sq-nsig__inner{padding:22px 16px}.sq-nsig__cmp{gap:10px}.sq-nsig__verd{min-width:0}.sq-nsig__name{font-size:14px}}\n.sq-nsig__geo-r{position:absolute;width:0;height:0;opacity:0;pointer-events:none}\n.sq-nsig__geo-tabs{display:inline-flex;border:1px solid rgba(47,230,201,.4);border-radius:999px;overflow:hidden;margin:0 0 14px}\n.sq-nsig__geo-tab{cursor:pointer;padding:6px 15px;font-size:11px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:rgba(232,240,247,.6)}\n.sq-nsig__geo-a{display:contents}.sq-nsig__geo-b{display:none}\n.sq-nsig__geo-r--a:checked~.sq-nsig__geo-tabs .sq-nsig__geo-tab--a,.sq-nsig__geo-r--b:checked~.sq-nsig__geo-tabs .sq-nsig__geo-tab--b{background:#2FE6C9;color:#04121f}\n.sq-nsig__geo-r--b:checked~.sq-nsig__cards .sq-nsig__geo-a,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-a{display:none}\n.sq-nsig__geo-r--b:checked~.sq-nsig__cards .sq-nsig__geo-b,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-b{display:contents}\n<\/style>\n<div class=\"sq-nsig\"><div class=\"sq-nsig__inner\"><span class=\"sq-nsig__tag\"><span class=\"dot\"><\/span>Squawka Signal &middot; Model vs market<\/span><h3 class=\"sq-nsig__title\">Detroit Lions @ Buffalo Bills<\/h3><p class=\"sq-nsig__meta\">Week 2 &middot; Thu Sep 17, 8:15 PM ET. Our Signal model makes the <b>Buffalo Bills<\/b> favorites by about <b>5<\/b> points, a 67% win probability.<\/p><div class=\"sq-nsig__cards\"><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/DET.png\" alt=\"DET\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">Detroit Lions<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Squawka<\/span><span class=\"sq-nsig__cmp-sig\">33%<\/span><\/span><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Market<\/span><span class=\"sq-nsig__cmp-mkt\">34%<\/span><\/span><span class=\"sq-nsig__verd sq-nsig__verd--fair\">&#9644; Fair<\/span><\/span><\/div><\/div><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/BUF.png\" alt=\"BUF\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">Buffalo Bills<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Squawka<\/span><span class=\"sq-nsig__cmp-sig\">67%<\/span><\/span><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Market<\/span><span class=\"sq-nsig__cmp-mkt\">66%<\/span><\/span><span class=\"sq-nsig__verd sq-nsig__verd--fair\">&#9644; Fair<\/span><\/span><\/div><\/div><\/div><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Projected line<\/span><span class=\"sq-nsig__mc-v\">Buffalo Bills -5<\/span><\/div><div class=\"sq-nsig__cta-row\" style=\"margin-top:14px\"><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/kalshi?q=us-all-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">Kalshi<\/a><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/polymarket?q=us-sg1-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">Polymarket<\/a><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/prophet-x?q=us-sg1-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">ProphetX<\/a><\/div><p class=\"sq-nsig__foot\">Squawka Signal is our model&#8217;s read against devigged market prices, updated after every result &mdash; not betting advice. <a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/nfl-signal-methodology\/\">How the NFL Signal works<\/a>. 21+. 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Full T&amp;Cs &amp; geo-restrictions apply: <a href=\"https:\/\/www.squawka.com\/us\/bet\/betting-sites\/kalshi\/\">Kalshi<\/a>, <a href=\"https:\/\/www.squawka.com\/us\/bet\/betting-sites\/polymarket\/\">Polymarket<\/a>, <a href=\"https:\/\/www.squawka.com\/us\/bet\/betting-sites\/prophetx\/\">ProphetX<\/a>.<\/p><\/div><\/div>\n\n\n<!-- sqstore:nfl-match home=buffalo-bills away=detroit-lions -->\n<div style=\"position:relative;overflow:hidden;border-radius:14px;margin:26px 0;display:flex;flex-wrap:wrap;align-items:stretch;gap:0;min-height:168px;background:linear-gradient(100deg,#0b1e3b,#13284d);color:#fff;font-family:'Bricolage Grotesque',system-ui,-apple-system,Segoe UI,Roboto,sans-serif;\"><div style=\"position:absolute;inset:0;background-image:url(&quot;data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20preserveAspectRatio%3D%22xMidYMid%20slice%22%20viewBox%3D%220%200%203000%203000%22%3E%3Cdefs%3E%3Cpattern%20id%3D%22a%22%20width%3D%2278%22%20height%3D%22175.5%22%20patternTransform%3D%22rotate%28-45%29%22%20patternUnits%3D%22userSpaceOnUse%22%3E%3Cpath%20fill%3D%22%23D50A0A%22%20d%3D%22m-38.22%20157.05-.78-78%2078-.78c.45%2043.12-34.12%2078.33-77.22%2078.78%22%2F%3E%3Cpath%20fill%3D%22%23D50A0A%22%20d%3D%22M77.22%200%2078%2081.6l-78%20.78C-.45%2035.67%2034.12.45%2077.22%200%22%2F%3E%3Cpath%20fill%3D%22%23D50A0A%22%20d%3D%22m37.78%20158.05-.78-78%2078-.78c.45%2043.12-34.12%2078.33-77.22%2078.78%22%2F%3E%3C%2Fpattern%3E%3C%2Fdefs%3E%3Crect%20width%3D%22100%25%22%20height%3D%22100%25%22%20fill%3D%22url%28%23a%29%22%2F%3E%3C%2Fsvg%3E&quot;);background-size:180px 180px;opacity:.13;\"><\/div><div style=\"position:relative;z-index:1;flex:1 1 300px;min-width:0;padding:22px 24px;display:flex;flex-direction:column;justify-content:center;gap:9px;\"><span style=\"display:inline-flex;align-items:center;gap:9px;font-size:11px;font-weight:700;letter-spacing:.14em;text-transform:uppercase;\"><span style=\"background:#D50A0A;color:#fff;padding:3px 8px;border-radius:5px;\">NFL<\/span><span style=\"color:#fff;\">Squawka Store<\/span><\/span><span style=\"font-size:25px;font-weight:800;letter-spacing:-.02em;line-height:1.06;\">Wear the Match<\/span><span style=\"font-size:14px;color:rgba(255,255,255,.78);max-width:42ch;\">Buffalo Bills vs Detroit Lions \u2014 pick up either team\u2019s official jersey, shipped from Fanatics.<\/span><span style=\"font-size:10.5px;color:rgba(255,255,255,.5);margin-top:2px;\">Affiliate links \u2014 Squawka may earn a commission on purchases.<\/span><\/div><div style=\"position:relative;z-index:1;flex:1 1 300px;display:flex;gap:12px;padding:16px 18px;\"><a href=\"https:\/\/fanatics.93n6tx.net\/c\/2650836\/669352\/9663?u=https%3A%2F%2Fwww.fanatics.com%2Fnfl%2Fbuffalo-bills&amp;subId1=wear-the-match&amp;subId2=lions-vs-bills-prediction-picks-odds-week-2&amp;subId3=squawka-us\" target=\"_blank\" rel=\"sponsored nofollow noopener\" style=\"flex:1;min-width:120px;text-decoration:none;display:flex;flex-direction:column;align-items:center;gap:8px;background:#f4f2f6;border-radius:10px;padding:14px 10px 12px;\"><img decoding=\"async\" src=\"https:\/\/feeds.frgimages.com\/_ss5_p-200897208+u-lllndyuk18b7nulnyhut+v-ydcfw65xwyhuuw19wncs.png?_hv=2&amp;w=340\" alt=\"Shop Bills jerseys\" loading=\"lazy\" style=\"width:100%;max-height:118px;object-fit:contain;mix-blend-mode:multiply;\"><span style=\"display:inline-flex;align-items:center;gap:6px;color:#141018;font-weight:800;font-size:12.5px;\">Shop Bills<\/span><\/a><a href=\"https:\/\/fanatics.93n6tx.net\/c\/2650836\/669352\/9663?u=https%3A%2F%2Fwww.fanatics.com%2Fnfl%2Fdetroit-lions&amp;subId1=wear-the-match&amp;subId2=lions-vs-bills-prediction-picks-odds-week-2&amp;subId3=squawka-us\" target=\"_blank\" rel=\"sponsored nofollow noopener\" style=\"flex:1;min-width:120px;text-decoration:none;display:flex;flex-direction:column;align-items:center;gap:8px;background:#f4f2f6;border-radius:10px;padding:14px 10px 12px;\"><img decoding=\"async\" src=\"https:\/\/feeds.frgimages.com\/_ss5_p-201587891+u-p1ysz08nshloblubrptb+v-rwvongujifijfrasuah8.png?_hv=2&amp;w=340\" alt=\"Shop Lions jerseys\" loading=\"lazy\" style=\"width:100%;max-height:118px;object-fit:contain;mix-blend-mode:multiply;\"><span style=\"display:inline-flex;align-items:center;gap:6px;color:#141018;font-weight:800;font-size:12.5px;\">Shop Lions<\/span><\/a><\/div><\/div>\n<!-- \/sqstore:nfl-match -->\n\n<!-- SQ_NFL_SIG_END -->\n\n\n\n<style>\n\/* Squawka NFL picks card - palette matched to the injected sq-nsig Signal units *\/\n.sqp{--cy:#2FE6C9;--val:#38D97A;--ovr:#FF6A5A;--fair:#FFC24B;--tx:#e8f0f7;--mut:rgba(232,240,247,.60);--line:rgba(255,255,255,.10);--gold:#FFC24B;position:relative;overflow:hidden;font-family:'Bricolage Grotesque',system-ui,-apple-system,Segoe UI,Roboto,sans-serif;color:var(--tx);max-width:960px;margin:14px auto 26px;border-radius:14px;background:linear-gradient(135deg,#0a2540 0%,#06182b 62%,#04121f 100%);box-shadow:0 14px 36px rgba(4,18,31,.34)}\n.sqp *{box-sizing:border-box}\n.sqp__wrap{padding:22px 26px 20px}\n.sqp__kick{display:inline-flex;align-items:center;gap:8px;font-size:11px;font-weight:800;letter-spacing:.14em;text-transform:uppercase;color:var(--cy)}\n.sqp__kick::before{content:'';width:7px;height:7px;border-radius:50%;background:var(--cy);box-shadow:0 0 9px 1px var(--cy)}\n.sqp__ttl{font-size:24px;font-weight:800;letter-spacing:-.3px;line-height:1.14;margin:12px 0 0;color:var(--tx)}\n.sqp__sub{margin:7px 0 0;font-size:14.5px;line-height:1.5;color:var(--mut);max-width:70ch}\n.sqp__crests{display:flex;align-items:center;gap:10px;margin-top:14px}\n.sqp__crests img{width:28px;height:28px;display:block}\n.sqp__at{font-size:12px;font-weight:700;color:var(--mut);letter-spacing:.1em}\n.sqp__h3{margin:20px 0 0;font-size:10.5px;font-weight:800;letter-spacing:.16em;text-transform:uppercase;color:var(--cy)}\n.sqp__list{margin-top:12px;border-top:1px solid var(--line)}\n.sqp__row{display:grid;grid-template-columns:1fr 126px;gap:14px;align-items:center;padding:14px 2px;border-bottom:1px solid var(--line)}\n.sqp__mkt{display:block;font-size:10px;font-weight:800;letter-spacing:.13em;text-transform:uppercase;color:var(--cy);margin-bottom:4px}\n.sqp__pk{font-size:15.5px;font-weight:800;line-height:1.25;color:var(--tx)}\n.sqp__top{display:inline-block;vertical-align:middle;margin-left:8px;font-size:9.5px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:#3a2c00;background:var(--gold);padding:3px 7px;border-radius:5px}\n.sqp__why{display:block;margin-top:5px;font-size:13.5px;line-height:1.5;color:var(--mut)}\n.sqp__pr{text-align:center}\n.sqp__val{display:block;font-size:23px;font-weight:800;color:var(--cy);line-height:1;text-decoration:none}\na.sqp__val:hover{text-decoration:underline}\n.sqp__stars{display:block;font-size:15px;line-height:1;letter-spacing:1px;color:var(--gold)}\n.sqp__stars .d{opacity:.24}\n.sqp__lab{display:block;font-size:10px;letter-spacing:.06em;text-transform:uppercase;color:var(--mut);margin-top:4px}\n.sqp__verd{display:inline-block;margin-top:6px;font-size:10.5px;font-weight:800;letter-spacing:.04em;padding:2px 7px;border-radius:5px}\n.sqp__verd--val{color:var(--val);background:rgba(56,217,122,.12)}\n.sqp__verd--ovr{color:var(--ovr);background:rgba(255,106,90,.12)}\n.sqp__verd--fair{color:var(--fair);background:rgba(255,194,75,.12)}\n.sqp__approach{margin:14px 0 0;font-size:13.5px;line-height:1.55;color:var(--tx)}\n.sqp__foot{margin:16px 0 0;padding-top:13px;border-top:1px solid var(--line);font-size:11.5px;line-height:1.55;color:rgba(232,240,247,.5)}\n.sqp__foot a{color:var(--cy);font-weight:700;text-decoration:none;border-bottom:1px solid rgba(47,230,201,.35)}\n@media(max-width:640px){\n.sqp__wrap{padding:18px 15px 16px}\n.sqp__ttl{font-size:20px}\n.sqp__row{grid-template-columns:1fr 100px;gap:10px}\n.sqp__val{font-size:20px}\n}\n<\/style>\n<div class=\"sqp\" id=\"sqp-detbuf\">\n<div class=\"sqp__wrap\">\n<span class=\"sqp__kick\">Week 1 &middot; Editorial pick<\/span>\n<h2 class=\"sqp__ttl\">Lions vs Bills: our editor&#8217;s props<\/h2>\n<p class=\"sqp__sub\">Two editorial calls to sit alongside the live Signal numbers on this page.<\/p>\n<div class=\"sqp__crests\">\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/DET.png\" alt=\"Lions\" loading=\"lazy\" width=\"28\" height=\"28\">\n<span class=\"sqp__at\">AT<\/span>\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/BUF.png\" alt=\"Bills\" loading=\"lazy\" width=\"28\" height=\"28\">\n<\/div>\n<h3 class=\"sqp__h3\">Our props<\/h3>\n<div class=\"sqp__list\">\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"Josh Allen 2+ passing touchdowns\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">Josh Allen 2+ passing touchdowns<\/span><span class=\"sqp__why\">Allen threw two against Houston at a 130.5 rating. Meanwhile Detroit conceded 410 passing yards and three scores to Tyler Shough in Week 1.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 4 of 5\">&#9733;&#9733;&#9733;&#9733;<span class=\"d\">&#9733;<\/span><\/span><span class=\"sqp__lab\">confidence<\/span><\/div>\n<\/div>\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"Jahmyr Gibbs 90+ rushing yards\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">Jahmyr Gibbs 90+ rushing yards<\/span><span class=\"sqp__why\">Gibbs carried 29 times for 156 yards and two touchdowns in the opener. Buffalo allowed 124 on the ground to Houston at 3.9 a carry.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 3 of 5\">&#9733;&#9733;&#9733;<span class=\"d\">&#9733;&#9733;<\/span><\/span><span class=\"sqp__lab\">confidence<\/span><\/div>\n<\/div>\n<\/div>\n<p class=\"sqp__foot\">An editorial call, not a Signal model output. 21+. Gambling Problem? Call 1-800-GAMBLER.<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Lions vs Bills: 2026 form so far<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">One game is a small sample, so read the table as a starting point rather than a settled picture. Even so, the shape of each win is instructive.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th>2026 season to date<\/th>\n<th class=\"has-text-align-center\" data-align=\"center\">Lions<\/th>\n<th class=\"has-text-align-center\" data-align=\"center\">Bills<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Record<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">1-0<\/td><td class=\"has-text-align-center\" data-align=\"center\">1-0<\/td><\/tr>\n<tr><td><strong>Points for<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">31<\/td><td class=\"has-text-align-center\" data-align=\"center\">36<\/td><\/tr>\n<tr><td><strong>Points against<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">30<\/td><td class=\"has-text-align-center\" data-align=\"center\">31<\/td><\/tr>\n<tr><td><strong>Point differential<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">+1<\/td><td class=\"has-text-align-center\" data-align=\"center\">+5<\/td><\/tr>\n<tr><td><strong>Total yards<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">369<\/td><td class=\"has-text-align-center\" data-align=\"center\">409<\/td><\/tr>\n<tr><td><strong>Yards per play<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">5.1<\/td><td class=\"has-text-align-center\" data-align=\"center\">7.9<\/td><\/tr>\n<tr><td><strong>Turnovers<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">1<\/td><td class=\"has-text-align-center\" data-align=\"center\">0<\/td><\/tr>\n<tr><td><strong>Third-down offense<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">38.5%<\/td><td class=\"has-text-align-center\" data-align=\"center\">33.3%<\/td><\/tr>\n<tr><td><strong>Red-zone offense<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">80.0%<\/td><td class=\"has-text-align-center\" data-align=\"center\">33.3%<\/td><\/tr>\n<tr><td><strong>Sacks recorded<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">5<\/td><td class=\"has-text-align-center\" data-align=\"center\">3<\/td><\/tr>\n<tr><td><strong>Opponent passer rating<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">87.6<\/td><td class=\"has-text-align-center\" data-align=\"center\">106.7<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Buffalo averaged 7.9 yards a play to Detroit&#8217;s 5.1, and did not turn the ball over. Detroit, by contrast, won the possession battle by more than 13 minutes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Lions vs Bills injury report and team news<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Buffalo move into the new Highmark Stadium for the first time in the regular season, a 60,108-seat replacement for the ground across the road. Thursday night is its opener.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This section updates as soon as the Out, Doubtful and Questionable tags land. Practice reports for a Thursday game arrive on a compressed schedule, so the picture firms up late.<\/p>\n\n\n\n<!-- SQ_NFL_INJ_START -->\n\n<style>\n.sq-ninj{border:1px solid #123f5c;border-radius:14px;overflow:hidden;margin:24px 0;font-family:'Bricolage Grotesque',system-ui,-apple-system,sans-serif;background:#0a2540;color:#e8f0f7}\n.sq-ninj__head{display:flex;align-items:baseline;justify-content:space-between;gap:10px;padding:13px 16px;background:#06182b;font-weight:800;font-size:13px;letter-spacing:.4px;text-transform:uppercase;color:#fff;border-bottom:1px solid #123f5c}\n.sq-ninj__head span{font-size:11px;font-weight:600;letter-spacing:0;text-transform:none;color:rgba(232,240,247,.6)}\n.sq-ninj__cols{display:flex;flex-wrap:wrap}\n.sq-ninj__col{flex:1 1 260px;padding:14px 16px}\n.sq-ninj__col+.sq-ninj__col{border-left:1px solid #123f5c}\n.sq-ninj__team{display:flex;align-items:center;gap:9px;font-weight:800;font-size:14px;color:#fff;margin-bottom:10px}\n.sq-ninj__team img{width:24px;height:24px;object-fit:contain}\n.sq-ninj__row{display:flex;align-items:center;gap:8px;padding:6px 0;border-top:1px solid rgba(255,255,255,.06);font-size:13.5px}\n.sq-ninj__nm{flex:1;min-width:0;color:#fff;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}\n.sq-ninj__pos{flex:0 0 auto;color:rgba(232,240,247,.55);font-size:11px;font-weight:700}\n.sq-ninj__st{flex:0 0 auto;font-size:10.5px;font-weight:800;letter-spacing:.04em;text-transform:uppercase;padding:3px 9px;border-radius:999px}\n.sq-ninj__st--out{background:rgba(255,106,90,.16);color:#FF6A5A}\n.sq-ninj__st--doubt{background:rgba(255,194,75,.16);color:#FFC24B}\n.sq-ninj__st--ques{background:rgba(232,240,247,.1);color:rgba(232,240,247,.8)}\n.sq-ninj__none{font-size:13px;color:rgba(232,240,247,.55);padding:4px 0}\n@media(max-width:520px){.sq-ninj__col+.sq-ninj__col{border-left:0;border-top:1px solid #123f5c}}\n<\/style><div class=\"sq-ninj\"><div class=\"sq-ninj__head\">Injury report &middot; Week 2<span>Official game-status report &mdash; updates through the week<\/span><\/div><div class=\"sq-ninj__cols\"><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/DET.png\" alt=\"DET\" loading=\"lazy\" width=\"24\" height=\"24\">Detroit Lions<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><\/div><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/BUF.png\" alt=\"BUF\" loading=\"lazy\" width=\"24\" height=\"24\">Buffalo Bills<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><\/div><\/div><\/div>\n\n<!-- SQ_NFL_INJ_END -->\n\n\n\n<h2 class=\"wp-block-heading\">Where Lions vs Bills is decided<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Detroit&#8217;s pass defense is the obvious pressure point. New Orleans threw for 410 yards against them, and Tyler Shough is not Josh Allen. Buffalo&#8217;s quarterback added two rushing touchdowns of his own in Houston.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The counter is Jahmyr Gibbs, who carried 29 times in the opener. Detroit ran 33 times in total and held the ball for 36:51, which is how they kept a 469-yard New Orleans offense at arm&#8217;s length.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Detroit&#8217;s front did land five sacks and two interceptions, so the pass rush is real. Nevertheless Buffalo gave up only two sacks and no turnovers in Week 1.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Players to watch<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Jahmyr Gibbs (DET, RB):<\/strong> 29 carries for 156 yards and two touchdowns in the opener.<\/li>\n<li><strong>Amon-Ra St. Brown (DET, WR):<\/strong> Ten catches and two touchdowns against New Orleans.<\/li>\n<li><strong>Josh Allen (BUF, QB):<\/strong> 334 passing yards at a 130.5 rating, plus two rushing scores.<\/li>\n<li><strong>Dalton Kincaid (BUF, TE):<\/strong> Five catches for 130 yards, the highest total on either side.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to watch Lions vs Bills<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The game kicks off at 8:15 PM ET on Thursday, September 17 at Highmark Stadium in Orchard Park. Prime Video carries it in the United States. Additionally it is the only game of the night, so there is no competing window.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr><th>Detail<\/th><th>Lions vs Bills<\/th><\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Date<\/strong><\/td><td>Thursday, September 17, 2026<\/td><\/tr>\n<tr><td><strong>Kickoff<\/strong><\/td><td>8:15 PM ET \/ 7:15 PM CT \/ 5:15 PM PT<\/td><\/tr>\n<tr><td><strong>Venue<\/strong><\/td><td>Highmark Stadium, Orchard Park, NY<\/td><\/tr>\n<tr><td><strong>TV<\/strong><\/td><td>Prime Video<\/td><\/tr>\n<tr><td><strong>Live stream<\/strong><\/td><td>Prime Video \/ NFL Game Pass (DAZN)<\/td><\/tr>\n<tr><td><strong>Week<\/strong><\/td><td>Week 2, 2026 NFL season<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Lions vs Bills prediction and score projection<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Our <strong>Lions vs Bills prediction<\/strong> is a Buffalo win, 30-24. Allen against a secondary that has just conceded 410 yards is the cleanest edge on the card.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Detroit will move the ball and will run it, and Gibbs is good enough to keep this close. Ultimately, though, the live win probability updates on this page through the week.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Every fixture in the round is covered across our <a href=\"\/us\/nfl\/\">NFL hub<\/a>, and Signal rates <a href=\"\/us\/nfl\/picks\/\">every Week 2 game<\/a> the same way.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Lions vs Bills FAQ<\/h2>\n\n\n\n<div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-detbuf-1\"><strong class=\"schema-faq-question\">Who is favored to win, the Lions or the Bills?<\/strong> <p class=\"schema-faq-answer\">Buffalo, at home. Both teams are 1-0, but the Bills averaged 7.9 yards a play in their opener against Detroit&#8217;s 5.1. The live win probability updates on this page through the week.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-detbuf-2\"><strong class=\"schema-faq-question\">What time is Lions vs Bills?<\/strong> <p class=\"schema-faq-answer\">8:15 PM ET on Thursday, September 17, which is 7:15 PM CT and 5:15 PM PT.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-detbuf-3\"><strong class=\"schema-faq-question\">What channel is Lions vs Bills on?<\/strong> <p class=\"schema-faq-answer\">Prime Video has the game in the United States. NFL Game Pass on DAZN carries it internationally.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-detbuf-4\"><strong class=\"schema-faq-question\">Is this the first game at the new Highmark Stadium?<\/strong> <p class=\"schema-faq-answer\">It is the first regular-season game there. Buffalo opened the season in Houston, so Thursday night is the new ground&#8217;s regular-season debut.<\/p><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>21+ | Gambling Problem? Call 1-800-GAMBLER | Signal probabilities and odds approximate at time of writing and subject to change<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our Lions vs Bills prediction leans to Buffalo in a meeting of two 1-0 teams who won their openers in opposite ways. Thursday night is also the first regular-season game at the new Highmark Stadium. Squawka Signal&#8217;s live read on this game, including where the value sits, updates on this page through the week. The&#8230;<\/p>\n","protected":false},"author":394,"featured_media":49973,"menu_order":0,"template":"","meta":{"_acf_changed":false,"_yoast_wpseo_focuskw":"lions vs bills prediction","_yoast_wpseo_title":"Lions vs Bills Prediction, Picks & Odds: Week 2 | Squawka","_yoast_wpseo_metadesc":"Our Lions vs Bills prediction, picks and odds for Thursday night in Orchard Park. 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