{"id":41293,"date":"2026-09-05T19:00:32","date_gmt":"2026-09-05T23:00:32","guid":{"rendered":"https:\/\/www.squawka.com\/us\/?post_type=nfl-news&#038;p=41293"},"modified":"2026-09-05T19:00:33","modified_gmt":"2026-09-05T23:00:33","slug":"cardinals-vs-chargers-prediction-picks-odds-week-1","status":"publish","type":"nfl-news","link":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/","title":{"rendered":"Cardinals vs Chargers Prediction &#038; Picks"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Our <strong>Cardinals vs Chargers prediction<\/strong> backs Los Angeles clearly. Arizona travels to SoFi Stadium on Sunday, September 13 for the late window. CBS has the 4:25 PM ET kickoff, one of four games in that slot. Both sides open the <a href=\"\/us\/nfl\/\">2026 NFL campaign<\/a> here. The block below carries Squawka Signal&#8217;s live read, moreover, including where the value sits. Signal rates <a href=\"\/us\/nfl\/picks\/\">every game on the Week 1 card<\/a> the same way.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Los Angeles finished 11-6 and reached the postseason; Arizona went 3-14 and lost their last nine. Indeed, that losing run is the longest carried into this weekend by any team.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Chargers held opponents to a 75.0 passer rating in 2025, the best mark of any team playing this round. Arizona, by contrast, allowed 59 sacks.<\/p>\n\n\n\n<!-- SQ_NFL_SIG_START -->\n\n<style>\n.sq-nsig{position:relative;overflow:hidden;border-radius:18px;margin:28px 0;isolation:isolate;background:radial-gradient(70% 90% at 18% 0%,rgba(47,230,201,.14) 0%,rgba(47,230,201,0) 60%),linear-gradient(135deg,#0a2540 0%,#06182b 60%,#040f1d 100%);box-shadow:0 18px 44px rgba(4,15,29,.5);font-family:'Bricolage Grotesque',system-ui,-apple-system,sans-serif;color:#e8f0f7}\n.sq-nsig::before{content:\"\";position:absolute;inset:0;background-image:url(\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20preserveAspectRatio%3D%22xMidYMid%20slice%22%20viewBox%3D%220%200%203000%203000%22%3E%3Cdefs%3E%3Cpattern%20id%3D%22a%22%20width%3D%2278%22%20height%3D%22175.5%22%20x%3D%220%22%20y%3D%220%22%20patternTransform%3D%22rotate%28-45%29%22%20patternUnits%3D%22userSpaceOnUse%22%3E%3Cpath%20fill%3D%22%23123f5c%22%20d%3D%22m-38.22%20157.05-.78-78%2078-.78c.45%2043.12-34.12%2078.33-77.22%2078.78%22%2F%3E%3Cpath%20fill%3D%22%23123f5c%22%20d%3D%22M77.22%200%2078%2081.6l-78%20.78C-.45%2035.67%2034.12.45%2077.22%200%22%2F%3E%3Cpath%20fill%3D%22%23123f5c%22%20d%3D%22m37.78%20158.05-.78-78%2078-.78c.45%2043.12-34.12%2078.33-77.22%2078.78%22%2F%3E%3C%2Fpattern%3E%3C%2Fdefs%3E%3Crect%20width%3D%22100%25%22%20height%3D%22100%25%22%20fill%3D%22url%28%23a%29%22%2F%3E%3C%2Fsvg%3E\");background-size:440px;opacity:.16;pointer-events:none;z-index:0}\n.sq-nsig__inner{position:relative;z-index:1;padding:28px 32px 26px}\n.sq-nsig__tag{display:inline-flex;align-items:center;gap:9px;border:1.5px solid rgba(47,230,201,.5);border-radius:999px;padding:7px 16px;color:#2FE6C9;font-weight:800;font-size:12px;letter-spacing:2.4px;text-transform:uppercase;background:rgba(6,24,43,.5);margin-bottom:14px}\n.sq-nsig__tag .dot{width:8px;height:8px;border-radius:50%;background:#2FE6C9;box-shadow:0 0 10px 1px #2FE6C9}\n.sq-nsig__title{color:#fff;font-weight:900;letter-spacing:-.6px;line-height:1.05;font-size:clamp(24px,2.8vw,30px);margin:0 0 6px}\n.sq-nsig__meta{color:rgba(232,240,247,.72);font-size:13.5px;font-weight:500;line-height:1.5;margin:0 0 16px;max-width:760px}\n.sq-nsig__key{display:flex;flex-wrap:wrap;gap:6px 18px;font-size:11.5px;font-weight:600;color:rgba(232,240,247,.6);margin:0 0 14px}\n.sq-nsig__up{color:#38D97A}.sq-nsig__down{color:#FF6A5A}.sq-nsig__flat{color:rgba(232,240,247,.5)}\n.sq-nsig__cards{display:flex;flex-direction:column;gap:9px;margin:0 0 16px}\n.sq-nsig__card{background:rgba(6,24,43,.5);border:1px solid rgba(47,230,201,.16);border-radius:13px;overflow:hidden}\n.sq-nsig__card[open]{border-color:rgba(47,230,201,.42);background:rgba(6,24,43,.72)}\n.sq-nsig__sum{list-style:none;cursor:pointer;display:flex;align-items:center;gap:12px;padding:13px 15px}\n.sq-nsig__sum::-webkit-details-marker{display:none}\n.sq-nsig__rank{flex:0 0 auto;width:24px;text-align:center;font-weight:900;font-size:16px;color:rgba(232,240,247,.42);font-variant-numeric:tabular-nums}\n.sq-nsig__crest{flex:0 0 auto;width:30px;height:30px;object-fit:contain}\n.sq-nsig__name{flex:1;min-width:0;font-weight:800;font-size:15.5px;color:#fff;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}\n.sq-nsig__cmp{flex:0 0 auto;display:flex;align-items:center;gap:16px}\n.sq-nsig__cmp-c{display:flex;flex-direction:column;align-items:flex-end;line-height:1.1}\n.sq-nsig__cmp-k{font-size:9px;font-weight:800;letter-spacing:.05em;text-transform:uppercase;color:rgba(232,240,247,.5);margin-bottom:2px}\n.sq-nsig__cmp-sig{font-size:19px;font-weight:900;color:#2FE6C9}\n.sq-nsig__cmp-mkt{font-size:15px;font-weight:700;color:rgba(232,240,247,.9)}\n.sq-nsig__verd{flex:0 0 auto;min-width:104px;text-align:right;font-size:12px;font-weight:800}\n.sq-nsig__verd--val{color:#38D97A}.sq-nsig__verd--fair{color:rgba(232,240,247,.55)}.sq-nsig__verd--lay{color:#FFC24B}.sq-nsig__verd--over{color:#FF6A5A}\n.sq-nsig__expand{flex:0 0 auto;width:26px;height:26px;border-radius:50%;background:rgba(47,230,201,.15);color:#2FE6C9;display:inline-flex;align-items:center;justify-content:center;font-size:12px;transition:transform .15s ease}\n.sq-nsig__card[open] .sq-nsig__expand{transform:rotate(180deg);background:rgba(47,230,201,.3)}\n.sq-nsig__det{padding:0 15px 15px 15px}\n.sq-nsig__metrics{display:flex;flex-wrap:wrap;gap:9px;margin-bottom:11px}\n.sq-nsig__metric{flex:1 1 120px;background:rgba(4,15,29,.6);border:1px solid rgba(255,255,255,.07);border-radius:11px;padding:11px 12px}\n.sq-nsig__metric span{display:block;font-size:9px;font-weight:800;letter-spacing:.06em;text-transform:uppercase;color:rgba(232,240,247,.5);margin-bottom:3px}\n.sq-nsig__metric b{font-size:19px;color:#fff;font-variant-numeric:tabular-nums}\n.sq-nsig__mc{background:rgba(4,15,29,.6);border:1px solid rgba(255,255,255,.07);border-radius:11px;padding:11px 12px;display:flex;align-items:center;gap:12px}\n.sq-nsig__mc-k{font-size:10px;font-weight:800;letter-spacing:.1em;text-transform:uppercase;color:rgba(232,240,247,.6)}\n.sq-nsig__mc-v{font-size:16px;font-weight:800;color:#fff;margin-left:auto}\n.sq-nsig__cta{display:inline-flex;align-items:center;justify-content:center;background:#2FE6C9;color:#04121f;font-weight:900;font-size:11px;letter-spacing:.5px;text-transform:uppercase;padding:9px 14px;border-radius:9px;text-decoration:none}\n.sq-nsig__cta-row{display:flex;flex-wrap:wrap;gap:12px;margin-top:4px}\n.sq-nsig__cta2{flex:1 1 220px;display:inline-flex;align-items:center;justify-content:center;background:#2FE6C9;color:#04121f;font-weight:900;font-size:14px;letter-spacing:1.2px;text-transform:uppercase;padding:14px 22px;border-radius:10px;text-decoration:none;min-height:48px}\n.sq-nsig__foot{font-size:11.5px;color:rgba(232,240,247,.5);margin:16px 0 0;line-height:1.55}\n.sq-nsig__foot a{color:#2FE6C9;text-decoration:underline}\n@media(max-width:560px){.sq-nsig__inner{padding:22px 16px}.sq-nsig__cmp{gap:10px}.sq-nsig__verd{min-width:0}.sq-nsig__name{font-size:14px}}\n.sq-nsig__geo-r{position:absolute;width:0;height:0;opacity:0;pointer-events:none}\n.sq-nsig__geo-tabs{display:inline-flex;border:1px solid rgba(47,230,201,.4);border-radius:999px;overflow:hidden;margin:0 0 14px}\n.sq-nsig__geo-tab{cursor:pointer;padding:6px 15px;font-size:11px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:rgba(232,240,247,.6)}\n.sq-nsig__geo-a{display:contents}.sq-nsig__geo-b{display:none}\n.sq-nsig__geo-r--a:checked~.sq-nsig__geo-tabs .sq-nsig__geo-tab--a,.sq-nsig__geo-r--b:checked~.sq-nsig__geo-tabs .sq-nsig__geo-tab--b{background:#2FE6C9;color:#04121f}\n.sq-nsig__geo-r--b:checked~.sq-nsig__cards .sq-nsig__geo-a,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-a{display:none}\n.sq-nsig__geo-r--b:checked~.sq-nsig__cards .sq-nsig__geo-b,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-b{display:contents}\n<\/style>\n<div class=\"sq-nsig\"><div class=\"sq-nsig__inner\"><span class=\"sq-nsig__tag\"><span class=\"dot\"><\/span>Squawka Signal &middot; Model vs market<\/span><h3 class=\"sq-nsig__title\">Arizona Cardinals @ Los Angeles Chargers<\/h3><p class=\"sq-nsig__meta\">Week 1 &middot; Sun Sep 13, 4:25 PM ET. Our Signal model makes the <b>Los Angeles Chargers<\/b> favourites by about <b>8<\/b> points, a 77% win probability.<\/p><div class=\"sq-nsig__cards\"><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/ARI.png\" alt=\"ARI\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">Arizona Cardinals<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Squawka<\/span><span class=\"sq-nsig__cmp-sig\">23%<\/span><\/span><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Market<\/span><span class=\"sq-nsig__cmp-mkt\">18%<\/span><\/span><span class=\"sq-nsig__verd sq-nsig__verd--val\">&#9650; Value<\/span><\/span><\/div><\/div><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/LAC.png\" alt=\"LAC\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">Los Angeles Chargers<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Squawka<\/span><span class=\"sq-nsig__cmp-sig\">77%<\/span><\/span><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Market<\/span><span class=\"sq-nsig__cmp-mkt\">82%<\/span><\/span><span class=\"sq-nsig__verd sq-nsig__verd--lay\">&#9660; Slight lay<\/span><\/span><\/div><\/div><\/div><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Projected line<\/span><span class=\"sq-nsig__mc-v\">Los Angeles Chargers -8<\/span><\/div><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Against the spread<\/span><span class=\"sq-nsig__mc-v\">Arizona Cardinals +10 &mdash; model Los Angeles Chargers -8 vs market Los Angeles Chargers -10<\/span><\/div><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Value<\/span><span class=\"sq-nsig__mc-v\">Arizona Cardinals &mdash; model 23% vs market 18%<\/span><\/div><div class=\"sq-nsig__cta-row\" style=\"margin-top:14px\"><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/kalshi?q=us-all-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">Kalshi<\/a><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/polymarket?q=us-sg1-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">Polymarket<\/a><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/prophet-x?q=us-sg1-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">ProphetX<\/a><\/div><p class=\"sq-nsig__foot\">Squawka Signal is our model&#8217;s read against devigged market prices, updated after every result &mdash; not betting advice. <a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/nfl-signal-methodology\/\">How the NFL Signal works<\/a>. 21+. Play responsibly.<\/p><\/div><\/div>\n\n\n<!-- sqstore:nfl-match home=los-angeles-chargers away=arizona-cardinals -->\n<div style=\"position:relative;overflow:hidden;border-radius:14px;margin:26px 0;display:flex;flex-wrap:wrap;align-items:stretch;gap:0;min-height:168px;background:linear-gradient(100deg,#0b1e3b,#13284d);color:#fff;font-family:'Bricolage Grotesque',system-ui,-apple-system,Segoe UI,Roboto,sans-serif;\"><div style=\"position:absolute;inset:0;background-image:url(&quot;data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20preserveAspectRatio%3D%22xMidYMid%20slice%22%20viewBox%3D%220%200%203000%203000%22%3E%3Cdefs%3E%3Cpattern%20id%3D%22a%22%20width%3D%2278%22%20height%3D%22175.5%22%20patternTransform%3D%22rotate%28-45%29%22%20patternUnits%3D%22userSpaceOnUse%22%3E%3Cpath%20fill%3D%22%23D50A0A%22%20d%3D%22m-38.22%20157.05-.78-78%2078-.78c.45%2043.12-34.12%2078.33-77.22%2078.78%22%2F%3E%3Cpath%20fill%3D%22%23D50A0A%22%20d%3D%22M77.22%200%2078%2081.6l-78%20.78C-.45%2035.67%2034.12.45%2077.22%200%22%2F%3E%3Cpath%20fill%3D%22%23D50A0A%22%20d%3D%22m37.78%20158.05-.78-78%2078-.78c.45%2043.12-34.12%2078.33-77.22%2078.78%22%2F%3E%3C%2Fpattern%3E%3C%2Fdefs%3E%3Crect%20width%3D%22100%25%22%20height%3D%22100%25%22%20fill%3D%22url%28%23a%29%22%2F%3E%3C%2Fsvg%3E&quot;);background-size:180px 180px;opacity:.13;\"><\/div><div style=\"position:relative;z-index:1;flex:1 1 300px;min-width:0;padding:22px 24px;display:flex;flex-direction:column;justify-content:center;gap:9px;\"><span style=\"display:inline-flex;align-items:center;gap:9px;font-size:11px;font-weight:700;letter-spacing:.14em;text-transform:uppercase;\"><span style=\"background:#D50A0A;color:#fff;padding:3px 8px;border-radius:5px;\">NFL<\/span><span style=\"color:#fff;\">Squawka Store<\/span><\/span><span style=\"font-size:25px;font-weight:800;letter-spacing:-.02em;line-height:1.06;\">Wear the Match<\/span><span style=\"font-size:14px;color:rgba(255,255,255,.78);max-width:42ch;\">Los Angeles Chargers vs Arizona Cardinals \u2014 pick up either team\u2019s official jersey, shipped from Fanatics.<\/span><span style=\"font-size:10.5px;color:rgba(255,255,255,.5);margin-top:2px;\">Affiliate links \u2014 Squawka may earn a commission on purchases.<\/span><\/div><div style=\"position:relative;z-index:1;flex:1 1 300px;display:flex;gap:12px;padding:16px 18px;\"><a href=\"https:\/\/fanatics.93n6tx.net\/c\/2650836\/669352\/9663?u=https%3A%2F%2Fwww.fanatics.com%2Fnfl%2Flos-angeles-chargers&amp;subId1=wear-the-match&amp;subId2=cardinals-vs-chargers-prediction-picks-odds-week-1&amp;subId3=squawka-us\" target=\"_blank\" rel=\"sponsored nofollow noopener\" style=\"flex:1;min-width:120px;text-decoration:none;display:flex;flex-direction:column;align-items:center;gap:8px;background:#f4f2f6;border-radius:10px;padding:14px 10px 12px;\"><img decoding=\"async\" src=\"https:\/\/feeds.frgimages.com\/_ss5_p-4906260+u-uh9fss903ot8b97l98vx+v-obtlfa0j0olkenjivytx.png?_hv=2&amp;w=340\" alt=\"Shop Chargers jerseys\" loading=\"lazy\" style=\"width:100%;max-height:118px;object-fit:contain;mix-blend-mode:multiply;\"><span style=\"display:inline-flex;align-items:center;gap:6px;color:#141018;font-weight:800;font-size:12.5px;\">Shop Chargers<\/span><\/a><a href=\"https:\/\/fanatics.93n6tx.net\/c\/2650836\/669352\/9663?u=https%3A%2F%2Fwww.fanatics.com%2Fnfl%2Farizona-cardinals&amp;subId1=wear-the-match&amp;subId2=cardinals-vs-chargers-prediction-picks-odds-week-1&amp;subId3=squawka-us\" target=\"_blank\" rel=\"sponsored nofollow noopener\" style=\"flex:1;min-width:120px;text-decoration:none;display:flex;flex-direction:column;align-items:center;gap:8px;background:#f4f2f6;border-radius:10px;padding:14px 10px 12px;\"><img decoding=\"async\" src=\"https:\/\/feeds.frgimages.com\/_ss5_p-200893314+u-zalhkwjs4waf4kuxavst+v-z9tovyiiixrtutyxjpf5.png?_hv=2&amp;w=340\" alt=\"Shop Cardinals jerseys\" loading=\"lazy\" style=\"width:100%;max-height:118px;object-fit:contain;mix-blend-mode:multiply;\"><span style=\"display:inline-flex;align-items:center;gap:6px;color:#141018;font-weight:800;font-size:12.5px;\">Shop Cardinals<\/span><\/a><\/div><\/div>\n<!-- \/sqstore:nfl-match -->\n\n<!-- SQ_NFL_SIG_END -->\n\n\n\n<style>\n\/* Squawka NFL picks card - palette matched to the injected sq-nsig Signal units *\/\n.sqp{--cy:#2FE6C9;--val:#38D97A;--ovr:#FF6A5A;--fair:#FFC24B;--tx:#e8f0f7;--mut:rgba(232,240,247,.60);--line:rgba(255,255,255,.10);--gold:#FFC24B;position:relative;overflow:hidden;font-family:'Bricolage Grotesque',system-ui,-apple-system,Segoe UI,Roboto,sans-serif;color:var(--tx);max-width:960px;margin:14px auto 26px;border-radius:14px;background:linear-gradient(135deg,#0a2540 0%,#06182b 62%,#04121f 100%);box-shadow:0 14px 36px rgba(4,18,31,.34)}\n.sqp *{box-sizing:border-box}\n.sqp__wrap{padding:22px 26px 20px}\n.sqp__kick{display:inline-flex;align-items:center;gap:8px;font-size:11px;font-weight:800;letter-spacing:.14em;text-transform:uppercase;color:var(--cy)}\n.sqp__kick::before{content:'';width:7px;height:7px;border-radius:50%;background:var(--cy);box-shadow:0 0 9px 1px var(--cy)}\n.sqp__ttl{font-size:24px;font-weight:800;letter-spacing:-.3px;line-height:1.14;margin:12px 0 0;color:var(--tx)}\n.sqp__sub{margin:7px 0 0;font-size:14.5px;line-height:1.5;color:var(--mut);max-width:70ch}\n.sqp__crests{display:flex;align-items:center;gap:10px;margin-top:14px}\n.sqp__crests img{width:28px;height:28px;display:block}\n.sqp__at{font-size:12px;font-weight:700;color:var(--mut);letter-spacing:.1em}\n.sqp__h3{margin:20px 0 0;font-size:10.5px;font-weight:800;letter-spacing:.16em;text-transform:uppercase;color:var(--cy)}\n.sqp__list{margin-top:12px;border-top:1px solid var(--line)}\n.sqp__row{display:grid;grid-template-columns:1fr 126px;gap:14px;align-items:center;padding:14px 2px;border-bottom:1px solid var(--line)}\n.sqp__mkt{display:block;font-size:10px;font-weight:800;letter-spacing:.13em;text-transform:uppercase;color:var(--cy);margin-bottom:4px}\n.sqp__pk{font-size:15.5px;font-weight:800;line-height:1.25;color:var(--tx)}\n.sqp__top{display:inline-block;vertical-align:middle;margin-left:8px;font-size:9.5px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:#3a2c00;background:var(--gold);padding:3px 7px;border-radius:5px}\n.sqp__why{display:block;margin-top:5px;font-size:13.5px;line-height:1.5;color:var(--mut)}\n.sqp__pr{text-align:center}\n.sqp__val{display:block;font-size:23px;font-weight:800;color:var(--cy);line-height:1;text-decoration:none}\na.sqp__val:hover{text-decoration:underline}\n.sqp__stars{display:block;font-size:15px;line-height:1;letter-spacing:1px;color:var(--gold)}\n.sqp__stars .d{opacity:.24}\n.sqp__lab{display:block;font-size:10px;letter-spacing:.06em;text-transform:uppercase;color:var(--mut);margin-top:4px}\n.sqp__verd{display:inline-block;margin-top:6px;font-size:10.5px;font-weight:800;letter-spacing:.04em;padding:2px 7px;border-radius:5px}\n.sqp__verd--val{color:var(--val);background:rgba(56,217,122,.12)}\n.sqp__verd--ovr{color:var(--ovr);background:rgba(255,106,90,.12)}\n.sqp__verd--fair{color:var(--fair);background:rgba(255,194,75,.12)}\n.sqp__approach{margin:14px 0 0;font-size:13.5px;line-height:1.55;color:var(--tx)}\n.sqp__foot{margin:16px 0 0;padding-top:13px;border-top:1px solid var(--line);font-size:11.5px;line-height:1.55;color:rgba(232,240,247,.5)}\n.sqp__foot a{color:var(--cy);font-weight:700;text-decoration:none;border-bottom:1px solid rgba(47,230,201,.35)}\n@media(max-width:640px){\n.sqp__wrap{padding:18px 15px 16px}\n.sqp__ttl{font-size:20px}\n.sqp__row{grid-template-columns:1fr 100px;gap:10px}\n.sqp__val{font-size:20px}\n}\n<\/style>\n<div class=\"sqp\" id=\"sqp-arilac\">\n<div class=\"sqp__wrap\">\n<span class=\"sqp__kick\">Week 1 &middot; Editorial pick<\/span>\n<h2 class=\"sqp__ttl\">Cardinals vs Chargers: our editor&#8217;s prop<\/h2>\n<p class=\"sqp__sub\">One editorial call to sit alongside the live Signal numbers above.<\/p>\n<div class=\"sqp__crests\">\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/ARI.png\" alt=\"Cardinals\" loading=\"lazy\" width=\"28\" height=\"28\">\n<span class=\"sqp__at\">AT<\/span>\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/LAC.png\" alt=\"Chargers\" loading=\"lazy\" width=\"28\" height=\"28\">\n<\/div>\n<h3 class=\"sqp__h3\">Our prop<\/h3>\n<div class=\"sqp__list\">\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"Justin Herbert over 1.5 passing touchdowns\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">Justin Herbert over 1.5 passing touchdowns<\/span><span class=\"sqp__why\">Herbert threw 26 touchdown passes in 2025. Meanwhile Arizona conceded 63.2% in the red zone and a 97.6 opponent passer rating.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 4 of 5\">&#9733;&#9733;&#9733;&#9733;<span class=\"d\">&#9733;<\/span><\/span><span class=\"sqp__lab\">confidence<\/span><\/div>\n<\/div>\n<\/div>\n<p class=\"sqp__foot\">An editorial call, not a Signal model output. 21+. Gambling Problem? Call 1-800-GAMBLER.<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs Chargers: 2025 season form<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Los Angeles finished 11-6 at plus 28. Arizona went 3-14 at minus 133, and the Cardinals lost their final nine games.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th>2025 regular season<\/th>\n<th class=\"has-text-align-center\" data-align=\"center\">Cardinals<\/th>\n<th class=\"has-text-align-center\" data-align=\"center\">Chargers<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Record<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">3-14<\/td><td class=\"has-text-align-center\" data-align=\"center\">11-6<\/td><\/tr>\n<tr><td><strong>Points for<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">355<\/td><td class=\"has-text-align-center\" data-align=\"center\">368<\/td><\/tr>\n<tr><td><strong>Points against<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">488<\/td><td class=\"has-text-align-center\" data-align=\"center\">340<\/td><\/tr>\n<tr><td><strong>Point differential<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">-133<\/td><td class=\"has-text-align-center\" data-align=\"center\">+28<\/td><\/tr>\n<tr><td><strong>Sacks recorded<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">30<\/td><td class=\"has-text-align-center\" data-align=\"center\">45<\/td><\/tr>\n<tr><td><strong>Sacks allowed<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">59<\/td><td class=\"has-text-align-center\" data-align=\"center\">60<\/td><\/tr>\n<tr><td><strong>Interceptions made<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">10<\/td><td class=\"has-text-align-center\" data-align=\"center\">19<\/td><\/tr>\n<tr><td><strong>Third-down offense<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">41.5%<\/td><td class=\"has-text-align-center\" data-align=\"center\">45.8%<\/td><\/tr>\n<tr><td><strong>Red-zone offense<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">54.1%<\/td><td class=\"has-text-align-center\" data-align=\"center\">47.4%<\/td><\/tr>\n<tr><td><strong>Red zone allowed<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">63.2%<\/td><td class=\"has-text-align-center\" data-align=\"center\">46.9%<\/td><\/tr>\n<tr><td><strong>Opponent passer rating<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">97.6<\/td><td class=\"has-text-align-center\" data-align=\"center\">75.0<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">The defensive rows separate them. Los Angeles held opponents to a 75.0 passer rating and made 19 interceptions, both the better marks in this fixture. However, the Chargers also allowed 60 sacks, so their line is no stronger than Arizona&#8217;s.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs Chargers injury report and team news<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This section updates as soon as the Out, Doubtful and Questionable tags appear. For now, one quarterback room is settled and the other is not.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Arizona has not confirmed a starter. Jacoby Brissett threw for 3,366 yards in 2025, though Gardner Minshew II and the rookie Carson Beck are both on the roster. Trey McBride and Michael Wilson lead the receivers regardless, meanwhile, with James Conner in the backfield.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Justin Herbert starts for Los Angeles. Ladd McConkey and Quentin Johnston lead the receivers, moreover, with Omarion Hampton carrying the run game and David Njoku at tight end.<\/p>\n\n\n\n<!-- SQ_NFL_INJ_START -->\n\n<style>\n.sq-ninj{border:1px solid #123f5c;border-radius:14px;overflow:hidden;margin:24px 0;font-family:'Bricolage Grotesque',system-ui,-apple-system,sans-serif;background:#0a2540;color:#e8f0f7}\n.sq-ninj__head{display:flex;align-items:baseline;justify-content:space-between;gap:10px;padding:13px 16px;background:#06182b;font-weight:800;font-size:13px;letter-spacing:.4px;text-transform:uppercase;color:#fff;border-bottom:1px solid #123f5c}\n.sq-ninj__head span{font-size:11px;font-weight:600;letter-spacing:0;text-transform:none;color:rgba(232,240,247,.6)}\n.sq-ninj__cols{display:flex;flex-wrap:wrap}\n.sq-ninj__col{flex:1 1 260px;padding:14px 16px}\n.sq-ninj__col+.sq-ninj__col{border-left:1px solid #123f5c}\n.sq-ninj__team{display:flex;align-items:center;gap:9px;font-weight:800;font-size:14px;color:#fff;margin-bottom:10px}\n.sq-ninj__team img{width:24px;height:24px;object-fit:contain}\n.sq-ninj__row{display:flex;align-items:center;gap:8px;padding:6px 0;border-top:1px solid rgba(255,255,255,.06);font-size:13.5px}\n.sq-ninj__nm{flex:1;min-width:0;color:#fff;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}\n.sq-ninj__pos{flex:0 0 auto;color:rgba(232,240,247,.55);font-size:11px;font-weight:700}\n.sq-ninj__st{flex:0 0 auto;font-size:10.5px;font-weight:800;letter-spacing:.04em;text-transform:uppercase;padding:3px 9px;border-radius:999px}\n.sq-ninj__st--out{background:rgba(255,106,90,.16);color:#FF6A5A}\n.sq-ninj__st--doubt{background:rgba(255,194,75,.16);color:#FFC24B}\n.sq-ninj__st--ques{background:rgba(232,240,247,.1);color:rgba(232,240,247,.8)}\n.sq-ninj__none{font-size:13px;color:rgba(232,240,247,.55);padding:4px 0}\n@media(max-width:520px){.sq-ninj__col+.sq-ninj__col{border-left:0;border-top:1px solid #123f5c}}\n<\/style><div class=\"sq-ninj\"><div class=\"sq-ninj__head\">Injury report &middot; Week 1<span>Official game-status report &mdash; updates through the week<\/span><\/div><div class=\"sq-ninj__cols\"><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/ARI.png\" alt=\"ARI\" loading=\"lazy\" width=\"24\" height=\"24\">Arizona Cardinals<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><\/div><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/LAC.png\" alt=\"LAC\" loading=\"lazy\" width=\"24\" height=\"24\">Los Angeles Chargers<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><\/div><\/div><\/div>\n\n<!-- SQ_NFL_INJ_END -->\n\n\n\n<h2 class=\"wp-block-heading\">The matchup that decides it: the Chargers secondary against an unsettled Arizona passing game<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Los Angeles conceded a 75.0 opponent passer rating in 2025 and intercepted 19 passes. Both figures lead this weekend&#8217;s fixtures.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Arizona threw for 3,955 yards, more than the Chargers managed. However, they allowed 59 sacks doing it, and the quarterback is still undecided.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Trey McBride is the counterweight. Indeed, 1,239 receiving yards from a tight end was sixth in the league last season, and he is the one Arizona player Los Angeles must account for.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Players to watch<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Justin Herbert (LAC, QB):<\/strong> 3,727 passing yards and 26 touchdowns in 2025, notably his most productive year.<\/li>\n<li><strong>Tuli Tuipulotu (LAC, OLB):<\/strong> 13 sacks last season, notably against a line that allowed 59.<\/li>\n<li><strong>Ladd McConkey (LAC, WR):<\/strong> Notably the Chargers&#8217; primary receiving target.<\/li>\n<li><strong>Trey McBride (ARI, TE):<\/strong> 1,239 receiving yards, indeed sixth in the league and first among tight ends.<\/li>\n<li><strong>James Conner (ARI, RB):<\/strong> Notably leads a backfield that gained 1,583 yards at 4.33 a carry.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to watch Cardinals vs Chargers<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The game kicks off at 4:25 PM ET on Sunday, September 13 at SoFi Stadium in Inglewood. CBS has the broadcast, meanwhile, with Paramount+ streaming it. Because this is the late Sunday window, coverage is regional, so check your local listings.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr><th>Detail<\/th><th>Cardinals vs Chargers<\/th><\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Date<\/strong><\/td><td>Sunday, September 13, 2026<\/td><\/tr>\n<tr><td><strong>Kickoff<\/strong><\/td><td>4:25 PM ET \/ 3:25 PM CT \/ 2:25 PM MT \/ 1:25 PM PT<\/td><\/tr>\n<tr><td><strong>Venue<\/strong><\/td><td>SoFi Stadium, Inglewood, CA<\/td><\/tr>\n<tr><td><strong>TV<\/strong><\/td><td>CBS<\/td><\/tr>\n<tr><td><strong>Live stream<\/strong><\/td><td>CBS \/ Paramount+<\/td><\/tr>\n<tr><td><strong>Week<\/strong><\/td><td>Week 1, 2026 NFL season<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs Chargers prediction and score projection<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Our <strong>Cardinals vs Chargers prediction<\/strong> is a comfortable Los Angeles win. The best pass defense on the slate against an offense with no confirmed quarterback is a straightforward read.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Arizona is not without weapons. Trey McBride and Michael Wilson both cleared 1,000 receiving yards, moreover, and the Cardinals moved the ball through the air all season. Nevertheless 59 sacks allowed tells you how it usually ended.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">So we will take the Chargers to win, 27-17. Which side carries the value, though, is a separate question from who wins, and the live read on that sits in the Signal block.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Signal rates every game on our <a href=\"\/us\/nfl\/picks\/\">NFL picks page<\/a>. Meanwhile the title race is priced through <a href=\"\/us\/outright-markets\/nfl-super-bowl-odds\/\">Super Bowl LXI odds<\/a>, with both conferences on the <a href=\"\/us\/outright-markets\/nfc-championship-odds\/\">NFC<\/a> and <a href=\"\/us\/outright-markets\/afc-championship-odds\/\">AFC Championship<\/a> pages. Finally, player markets sit with our <a href=\"\/us\/nfl\/props\/\">NFL player props<\/a> coverage, and kickoff is confirmed on <a href=\"https:\/\/www.nfl.com\/schedules\/\" rel=\"noopener\" target=\"_blank\">NFL.com<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs Chargers FAQ<\/h2>\n\n\n\n<div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-arilac-1\"><strong class=\"schema-faq-question\">Who is favored to win, the Cardinals or the Chargers?<\/strong> <p class=\"schema-faq-answer\">Los Angeles, clearly. The Chargers finished 11-6 and allowed a 75.0 opponent passer rating, the best mark on this weekend&#8217;s slate, while Arizona went 3-14. Ultimately the live win probability and the current market price both sit in the Signal block on this page.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-arilac-2\"><strong class=\"schema-faq-question\">What is the spread for Cardinals vs Chargers?<\/strong> <p class=\"schema-faq-answer\">Spreads move all week; therefore both the live line and our model&#8217;s projected line sit in the Signal block rather than in this answer. As a guide to the gap: Los Angeles finished 11-6 at plus 28, Arizona 3-14 at minus 133.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-arilac-3\"><strong class=\"schema-faq-question\">Where can I watch Cardinals vs Chargers?<\/strong> <p class=\"schema-faq-answer\">CBS has the broadcast and Paramount+ streams it. Kickoff is 4:25 PM ET on Sunday, September 13, 2026 from SoFi Stadium in Inglewood. Notably, coverage is regional in the late window.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-arilac-4\"><strong class=\"schema-faq-question\">Who starts at quarterback for Arizona?<\/strong> <p class=\"schema-faq-answer\">Arizona had not confirmed a starter at the time of writing. Jacoby Brissett threw for 3,366 yards in 2025, and Gardner Minshew II and the rookie Carson Beck are also on the roster.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-arilac-5\"><strong class=\"schema-faq-question\">What is the score prediction for Cardinals vs Chargers?<\/strong> <p class=\"schema-faq-answer\">Chargers 27-17. Los Angeles held opponents to a 75.0 passer rating last season, and Arizona allowed 59 sacks while losing their final nine games.<\/p><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>21+ | Gambling Problem? Call 1-800-GAMBLER | Signal probabilities and odds approximate at time of writing and subject to change<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our Cardinals vs Chargers prediction backs Los Angeles clearly. Arizona travels to SoFi Stadium on Sunday, September 13 for the late window. CBS has the 4:25 PM ET kickoff, one of four games in that slot. Both sides open the 2026 NFL campaign here. The block below carries Squawka Signal&#8217;s live read, moreover, including where&#8230;<\/p>\n","protected":false},"author":394,"featured_media":41292,"menu_order":0,"template":"","meta":{"_acf_changed":false,"_yoast_wpseo_focuskw":"cardinals vs chargers prediction","_yoast_wpseo_title":"Cardinals vs Chargers Prediction & Picks | Squawka","_yoast_wpseo_metadesc":"Our Cardinals vs Chargers prediction, picks and odds for Week 1 at SoFi Stadium. The best pass defense on the slate hosts a 3-14 team. Kickoff 4:25 PM ET.","footnotes":""},"tags":[375,376,350],"class_list":["post-41293","nfl-news","type-nfl-news","status-publish","has-post-thumbnail","hentry","tag-arizona-cardinals","tag-los-angeles-chargers","tag-nfl"],"acf":{"external_featured_image_url":"","hide_featured_image_pattern":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Cardinals vs Chargers Prediction &amp; Picks | Squawka<\/title>\n<meta name=\"description\" content=\"Our Cardinals vs Chargers prediction, picks and odds for Week 1 at SoFi Stadium. The best pass defense on the slate hosts a 3-14 team. Kickoff 4:25 PM ET.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cardinals vs Chargers Prediction &amp; Picks\" \/>\n<meta property=\"og:description\" content=\"Our Cardinals vs Chargers prediction, picks and odds for Week 1 at SoFi Stadium. The best pass defense on the slate hosts a 3-14 team. Kickoff 4:25 PM ET.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/\" \/>\n<meta property=\"og:site_name\" content=\"Squawka | US\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SquawkaFootballNews\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-05T23:00:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/media.squawka.com\/images\/sites\/13\/2026\/09\/05180726\/cardinals-vs-chargers-prediction-picks-odds-week-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2400\" \/>\n\t<meta property=\"og:image:height\" content=\"1260\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Squawka\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":[\"WebPage\",\"FAQPage\"],\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/\",\"url\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/\",\"name\":\"Cardinals vs Chargers Prediction & Picks | Squawka\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/media.squawka.com\\\/images\\\/sites\\\/13\\\/2026\\\/09\\\/05180726\\\/cardinals-vs-chargers-prediction-picks-odds-week-1.jpg\",\"datePublished\":\"2026-09-05T23:00:32+00:00\",\"dateModified\":\"2026-09-05T23:00:33+00:00\",\"description\":\"Our Cardinals vs Chargers prediction, picks and odds for Week 1 at SoFi Stadium. The best pass defense on the slate hosts a 3-14 team. Kickoff 4:25 PM ET.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#breadcrumb\"},\"mainEntity\":[{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#faq-arilac-1\"},{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#faq-arilac-2\"},{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#faq-arilac-3\"},{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#faq-arilac-4\"},{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#faq-arilac-5\"}],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#primaryimage\",\"url\":\"https:\\\/\\\/media.squawka.com\\\/images\\\/sites\\\/13\\\/2026\\\/09\\\/05180726\\\/cardinals-vs-chargers-prediction-picks-odds-week-1.jpg\",\"contentUrl\":\"https:\\\/\\\/media.squawka.com\\\/images\\\/sites\\\/13\\\/2026\\\/09\\\/05180726\\\/cardinals-vs-chargers-prediction-picks-odds-week-1.jpg\",\"width\":2400,\"height\":1260,\"caption\":\"Cardinals vs Chargers prediction, picks and odds for Week 1 of the 2026 NFL season\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"NFL News\",\"item\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Cardinals vs Chargers Prediction &#038; Picks\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/#website\",\"url\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/\",\"name\":\"Squawka US\",\"description\":\"Soccer News and Predictions | Stats, Betting\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/#organization\",\"name\":\"Squawka US\",\"url\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/media.squawka.com\\\/images\\\/sites\\\/13\\\/2026\\\/04\\\/23072352\\\/Squawka-Logo.jpg\",\"contentUrl\":\"https:\\\/\\\/media.squawka.com\\\/images\\\/sites\\\/13\\\/2026\\\/04\\\/23072352\\\/Squawka-Logo.jpg\",\"width\":1000,\"height\":1000,\"caption\":\"Squawka US\"},\"image\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/SquawkaFootballNews\\\/\",\"https:\\\/\\\/x.com\\\/Squawka\",\"https:\\\/\\\/www.instagram.com\\\/squawkafootball\\\/\"],\"description\":\"Squawka is a football editorial site covering the Premier League, Champions League, MLS, Liga MX, FIFA World Cup 2026 and the wider international game. We publish match previews, tactical analysis, player and team stats, outright odds, betting tips, streaming guides and long-form features for a committed football audience. Founded in the UK and part of OneTwenty Group, Squawka now runs localised editions for the UK (squawka.com\\\/en\\\/), United States (squawka.com\\\/us\\\/), Mexican-Spanish (squawka.com\\\/us-es\\\/), Ireland, Netherlands, Nigeria, Kenya, Uganda, South Africa and Ghana. Each edition is editorially tailored to its market, with locale-specific competition focus, operator compliance and commercial partnerships. Traffic skews toward high-intent football readers \u2014 supporters researching fixtures, form, odds and where to watch \u2014 making Squawka a strong fit for sportsbook, prediction-market, DFS, streaming and sports-merchandise brands across the UK, Europe and North America.\",\"foundingDate\":\"2012-06-11\"},{\"@type\":\"Question\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#faq-arilac-1\",\"position\":1,\"url\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#faq-arilac-1\",\"name\":\"Who is favored to win, the Cardinals or the Chargers?\",\"answerCount\":1,\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Los Angeles, clearly. The Chargers finished 11-6 and allowed a 75.0 opponent passer rating, the best mark on this weekend's slate, while Arizona went 3-14. Ultimately the live win probability and the current market price both sit in the Signal block on this page.\",\"inLanguage\":\"en-US\"},\"inLanguage\":\"en-US\"},{\"@type\":\"Question\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#faq-arilac-2\",\"position\":2,\"url\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#faq-arilac-2\",\"name\":\"What is the spread for Cardinals vs Chargers?\",\"answerCount\":1,\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Spreads move all week; therefore both the live line and our model's projected line sit in the Signal block rather than in this answer. As a guide to the gap: Los Angeles finished 11-6 at plus 28, Arizona 3-14 at minus 133.\",\"inLanguage\":\"en-US\"},\"inLanguage\":\"en-US\"},{\"@type\":\"Question\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#faq-arilac-3\",\"position\":3,\"url\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#faq-arilac-3\",\"name\":\"Where can I watch Cardinals vs Chargers?\",\"answerCount\":1,\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"CBS has the broadcast and Paramount+ streams it. Kickoff is 4:25 PM ET on Sunday, September 13, 2026 from SoFi Stadium in Inglewood. Notably, coverage is regional in the late window.\",\"inLanguage\":\"en-US\"},\"inLanguage\":\"en-US\"},{\"@type\":\"Question\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#faq-arilac-4\",\"position\":4,\"url\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#faq-arilac-4\",\"name\":\"Who starts at quarterback for Arizona?\",\"answerCount\":1,\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Arizona had not confirmed a starter at the time of writing. Jacoby Brissett threw for 3,366 yards in 2025, and Gardner Minshew II and the rookie Carson Beck are also on the roster.\",\"inLanguage\":\"en-US\"},\"inLanguage\":\"en-US\"},{\"@type\":\"Question\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#faq-arilac-5\",\"position\":5,\"url\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/cardinals-vs-chargers-prediction-picks-odds-week-1\\\/#faq-arilac-5\",\"name\":\"What is the score prediction for Cardinals vs Chargers?\",\"answerCount\":1,\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Chargers 27-17. Los Angeles held opponents to a 75.0 passer rating last season, and Arizona allowed 59 sacks while losing their final nine games.\",\"inLanguage\":\"en-US\"},\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Cardinals vs Chargers Prediction & Picks | Squawka","description":"Our Cardinals vs Chargers prediction, picks and odds for Week 1 at SoFi Stadium. The best pass defense on the slate hosts a 3-14 team. Kickoff 4:25 PM ET.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/","og_locale":"en_US","og_type":"article","og_title":"Cardinals vs Chargers Prediction & Picks","og_description":"Our Cardinals vs Chargers prediction, picks and odds for Week 1 at SoFi Stadium. The best pass defense on the slate hosts a 3-14 team. Kickoff 4:25 PM ET.","og_url":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/","og_site_name":"Squawka | US","article_publisher":"https:\/\/www.facebook.com\/SquawkaFootballNews\/","article_modified_time":"2026-09-05T23:00:33+00:00","og_image":[{"width":2400,"height":1260,"url":"https:\/\/media.squawka.com\/images\/sites\/13\/2026\/09\/05180726\/cardinals-vs-chargers-prediction-picks-odds-week-1.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_site":"@Squawka","twitter_misc":{"Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":["WebPage","FAQPage"],"@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/","url":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/","name":"Cardinals vs Chargers Prediction & Picks | Squawka","isPartOf":{"@id":"https:\/\/www.squawka.com\/us\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#primaryimage"},"image":{"@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#primaryimage"},"thumbnailUrl":"https:\/\/media.squawka.com\/images\/sites\/13\/2026\/09\/05180726\/cardinals-vs-chargers-prediction-picks-odds-week-1.jpg","datePublished":"2026-09-05T23:00:32+00:00","dateModified":"2026-09-05T23:00:33+00:00","description":"Our Cardinals vs Chargers prediction, picks and odds for Week 1 at SoFi Stadium. The best pass defense on the slate hosts a 3-14 team. Kickoff 4:25 PM ET.","breadcrumb":{"@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#breadcrumb"},"mainEntity":[{"@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#faq-arilac-1"},{"@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#faq-arilac-2"},{"@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#faq-arilac-3"},{"@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#faq-arilac-4"},{"@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#faq-arilac-5"}],"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#primaryimage","url":"https:\/\/media.squawka.com\/images\/sites\/13\/2026\/09\/05180726\/cardinals-vs-chargers-prediction-picks-odds-week-1.jpg","contentUrl":"https:\/\/media.squawka.com\/images\/sites\/13\/2026\/09\/05180726\/cardinals-vs-chargers-prediction-picks-odds-week-1.jpg","width":2400,"height":1260,"caption":"Cardinals vs Chargers prediction, picks and odds for Week 1 of the 2026 NFL season"},{"@type":"BreadcrumbList","@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.squawka.com\/us\/"},{"@type":"ListItem","position":2,"name":"NFL News","item":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/"},{"@type":"ListItem","position":3,"name":"Cardinals vs Chargers Prediction &#038; Picks"}]},{"@type":"WebSite","@id":"https:\/\/www.squawka.com\/us\/#website","url":"https:\/\/www.squawka.com\/us\/","name":"Squawka US","description":"Soccer News and Predictions | Stats, Betting","publisher":{"@id":"https:\/\/www.squawka.com\/us\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.squawka.com\/us\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.squawka.com\/us\/#organization","name":"Squawka US","url":"https:\/\/www.squawka.com\/us\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.squawka.com\/us\/#\/schema\/logo\/image\/","url":"https:\/\/media.squawka.com\/images\/sites\/13\/2026\/04\/23072352\/Squawka-Logo.jpg","contentUrl":"https:\/\/media.squawka.com\/images\/sites\/13\/2026\/04\/23072352\/Squawka-Logo.jpg","width":1000,"height":1000,"caption":"Squawka US"},"image":{"@id":"https:\/\/www.squawka.com\/us\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/SquawkaFootballNews\/","https:\/\/x.com\/Squawka","https:\/\/www.instagram.com\/squawkafootball\/"],"description":"Squawka is a football editorial site covering the Premier League, Champions League, MLS, Liga MX, FIFA World Cup 2026 and the wider international game. We publish match previews, tactical analysis, player and team stats, outright odds, betting tips, streaming guides and long-form features for a committed football audience. Founded in the UK and part of OneTwenty Group, Squawka now runs localised editions for the UK (squawka.com\/en\/), United States (squawka.com\/us\/), Mexican-Spanish (squawka.com\/us-es\/), Ireland, Netherlands, Nigeria, Kenya, Uganda, South Africa and Ghana. Each edition is editorially tailored to its market, with locale-specific competition focus, operator compliance and commercial partnerships. Traffic skews toward high-intent football readers \u2014 supporters researching fixtures, form, odds and where to watch \u2014 making Squawka a strong fit for sportsbook, prediction-market, DFS, streaming and sports-merchandise brands across the UK, Europe and North America.","foundingDate":"2012-06-11"},{"@type":"Question","@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#faq-arilac-1","position":1,"url":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#faq-arilac-1","name":"Who is favored to win, the Cardinals or the Chargers?","answerCount":1,"acceptedAnswer":{"@type":"Answer","text":"Los Angeles, clearly. The Chargers finished 11-6 and allowed a 75.0 opponent passer rating, the best mark on this weekend's slate, while Arizona went 3-14. Ultimately the live win probability and the current market price both sit in the Signal block on this page.","inLanguage":"en-US"},"inLanguage":"en-US"},{"@type":"Question","@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#faq-arilac-2","position":2,"url":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#faq-arilac-2","name":"What is the spread for Cardinals vs Chargers?","answerCount":1,"acceptedAnswer":{"@type":"Answer","text":"Spreads move all week; therefore both the live line and our model's projected line sit in the Signal block rather than in this answer. As a guide to the gap: Los Angeles finished 11-6 at plus 28, Arizona 3-14 at minus 133.","inLanguage":"en-US"},"inLanguage":"en-US"},{"@type":"Question","@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#faq-arilac-3","position":3,"url":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#faq-arilac-3","name":"Where can I watch Cardinals vs Chargers?","answerCount":1,"acceptedAnswer":{"@type":"Answer","text":"CBS has the broadcast and Paramount+ streams it. Kickoff is 4:25 PM ET on Sunday, September 13, 2026 from SoFi Stadium in Inglewood. Notably, coverage is regional in the late window.","inLanguage":"en-US"},"inLanguage":"en-US"},{"@type":"Question","@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#faq-arilac-4","position":4,"url":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#faq-arilac-4","name":"Who starts at quarterback for Arizona?","answerCount":1,"acceptedAnswer":{"@type":"Answer","text":"Arizona had not confirmed a starter at the time of writing. Jacoby Brissett threw for 3,366 yards in 2025, and Gardner Minshew II and the rookie Carson Beck are also on the roster.","inLanguage":"en-US"},"inLanguage":"en-US"},{"@type":"Question","@id":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#faq-arilac-5","position":5,"url":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-chargers-prediction-picks-odds-week-1\/#faq-arilac-5","name":"What is the score prediction for Cardinals vs Chargers?","answerCount":1,"acceptedAnswer":{"@type":"Answer","text":"Chargers 27-17. Los Angeles held opponents to a 75.0 passer rating last season, and Arizona allowed 59 sacks while losing their final nine games.","inLanguage":"en-US"},"inLanguage":"en-US"}]}},"yoast_title":"Cardinals vs Chargers Prediction & Picks | Squawka","yoast_description":"Our Cardinals vs Chargers prediction, picks and odds for Week 1 at SoFi Stadium. The best pass defense on the slate hosts a 3-14 team. Kickoff 4:25 PM ET.","yoast_keyword":"cardinals vs chargers prediction","_links":{"self":[{"href":"https:\/\/www.squawka.com\/us\/wp-json\/wp\/v2\/nfl-news\/41293","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.squawka.com\/us\/wp-json\/wp\/v2\/nfl-news"}],"about":[{"href":"https:\/\/www.squawka.com\/us\/wp-json\/wp\/v2\/types\/nfl-news"}],"author":[{"embeddable":true,"href":"https:\/\/www.squawka.com\/us\/wp-json\/wp\/v2\/users\/394"}],"version-history":[{"count":2,"href":"https:\/\/www.squawka.com\/us\/wp-json\/wp\/v2\/nfl-news\/41293\/revisions"}],"predecessor-version":[{"id":41314,"href":"https:\/\/www.squawka.com\/us\/wp-json\/wp\/v2\/nfl-news\/41293\/revisions\/41314"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.squawka.com\/us\/wp-json\/wp\/v2\/media\/41292"}],"wp:attachment":[{"href":"https:\/\/www.squawka.com\/us\/wp-json\/wp\/v2\/media?parent=41293"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.squawka.com\/us\/wp-json\/wp\/v2\/tags?post=41293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}