{"id":1496153,"date":"2026-09-22T18:05:53","date_gmt":"2026-09-22T17:05:53","guid":{"rendered":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/cardinals-vs-49ers-prediction-picks-odds-week-3\/"},"modified":"2026-09-22T18:05:54","modified_gmt":"2026-09-22T17:05:54","slug":"cardinals-vs-49ers-prediction-picks-odds-week-3","status":"publish","type":"nfl-news","link":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/cardinals-vs-49ers-prediction-picks-odds-week-3\/","title":{"rendered":"Cardinals vs 49ers Prediction &#038; Tips"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Our <strong>Cardinals vs 49ers prediction<\/strong> follows a San Francisco side that has not let anyone near its quarterback. Squawka Signal&#8217;s live read updates on this page through the week.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The <a href=\"https:\/\/www.squawka.com\/en\/nfl\/teams\/san-francisco-49ers\/\">San Francisco 49ers<\/a> have conceded no sacks in two games, converted 63.2% of their third downs and scored on 87.5% of their red-zone trips. The <a href=\"https:\/\/www.squawka.com\/en\/nfl\/teams\/arizona-cardinals\/\">Arizona Cardinals<\/a> managed 151 total yards at home against Seattle.<\/p>\n\n\n\n<!-- SQ_NFL_SIG_START -->\n\n<style>\n.sq-nsig{position:relative;overflow:hidden;border-radius:18px;margin:28px 0;isolation:isolate;background:radial-gradient(70% 90% at 18% 0%,rgba(47,230,201,.14) 0%,rgba(47,230,201,0) 60%),linear-gradient(135deg,#0a2540 0%,#06182b 60%,#040f1d 100%);box-shadow:0 18px 44px rgba(4,15,29,.5);font-family:'Bricolage 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a{color:#2FE6C9;text-decoration:underline}\n@media(max-width:560px){.sq-nsig__inner{padding:22px 16px}.sq-nsig__cmp{gap:10px}.sq-nsig__verd{min-width:0}.sq-nsig__name{font-size:14px}}\n.sq-nsig__geo-r{position:absolute;width:0;height:0;opacity:0;pointer-events:none}\n.sq-nsig__geo-tabs{display:inline-flex;border:1px solid rgba(47,230,201,.4);border-radius:999px;overflow:hidden;margin:0 0 14px}\n.sq-nsig__geo-tab{cursor:pointer;padding:6px 15px;font-size:11px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:rgba(232,240,247,.6)}\n.sq-nsig__geo-a{display:contents}.sq-nsig__geo-b{display:none}\n.sq-nsig__geo-r--a:checked~.sq-nsig__geo-tabs .sq-nsig__geo-tab--a,.sq-nsig__geo-r--b:checked~.sq-nsig__geo-tabs .sq-nsig__geo-tab--b{background:#2FE6C9;color:#04121f}\n.sq-nsig__geo-r--b:checked~.sq-nsig__cards .sq-nsig__geo-a,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-a{display:none}\n.sq-nsig__geo-r--b:checked~.sq-nsig__cards .sq-nsig__geo-b,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-b{display:contents}\n<\/style>\n<div class=\"sq-nsig\"><div class=\"sq-nsig__inner\"><span class=\"sq-nsig__tag\"><span class=\"dot\"><\/span>Squawka Signal &middot; Model read<\/span><h3 class=\"sq-nsig__title\">Arizona Cardinals @ San Francisco 49ers<\/h3><p class=\"sq-nsig__meta\">Week 3 &middot; Sun Sep 27, 4:05 PM ET. Our Signal model makes the <b>San Francisco 49ers<\/b> favourites by about <b>9<\/b> points, a 79% win probability.<\/p><div class=\"sq-nsig__cards\"><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/ARI.png\" alt=\"ARI\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">Arizona Cardinals<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Win prob<\/span><span class=\"sq-nsig__cmp-sig\">21%<\/span><\/span><\/span><\/div><\/div><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"SF\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">San Francisco 49ers<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Win prob<\/span><span class=\"sq-nsig__cmp-sig\">79%<\/span><\/span><\/span><\/div><\/div><\/div><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Projected line<\/span><span class=\"sq-nsig__mc-v\">San Francisco 49ers -9<\/span><\/div><div class=\"sq-nsig__cta-row\" style=\"margin-top:14px\"><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/boylesports?q=gb-nfl-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">BoyleSports<\/a><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/bet365?q=gb-nfl-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">bet365<\/a><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/sky-bet?q=gb-nfl-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">Sky Bet<\/a><\/div><p class=\"sq-nsig__foot\">Squawka Signal is our model&#8217;s read, updated after every result &mdash; not betting advice. <a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/nfl-signal-methodology\/\">How the NFL Signal works<\/a>. 18+. BeGambleAware.org. Please gamble responsibly. 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Editorial pick<\/span>\n<h2 class=\"sqp__ttl\">Cardinals vs 49ers: our editor&#8217;s props<\/h2>\n<p class=\"sqp__sub\">Two editorial calls to sit alongside the live Signal numbers on this page.<\/p>\n<div class=\"sqp__crests\">\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/en\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/ARI.png\" alt=\"Cardinals\" loading=\"lazy\" width=\"28\" height=\"28\">\n<span class=\"sqp__at\">AT<\/span>\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/en\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"49ers\" loading=\"lazy\" width=\"28\" height=\"28\">\n<\/div>\n<h3 class=\"sqp__h3\">Our props<\/h3>\n<div class=\"sqp__list\">\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"Brock Purdy 2+ passing touchdowns\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">Brock Purdy 2+ passing touchdowns<\/span><span class=\"sqp__why\">Purdy threw two at a 149.1 rating against Miami and San Francisco have five touchdown passes in two games. Arizona have conceded four and a 110.9 rating.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 4 of 5\">&#9733;&#9733;&#9733;&#9733;<span class=\"o\">&#9734;<\/span><\/span><span class=\"sqp__lab\">4\/5 confidence<\/span><\/div>\n<\/div>\n<div class=\"sqp__row\" data-market=\"Team total\" data-selection=\"Arizona under 18.5 points\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Team total<\/span><span class=\"sqp__pk\">Arizona under 18.5 points<\/span><span class=\"sqp__why\">The Cardinals gained 151 yards against Seattle and have three touchdowns all season. San Francisco have conceded two.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 3 of 5\">&#9733;&#9733;&#9733;<span class=\"o\">&#9734;&#9734;<\/span><\/span><span class=\"sqp__lab\">3\/5 confidence<\/span><\/div>\n<\/div>\n<\/div>\n<p class=\"sqp__foot\">An editorial call, not a Signal model output. 18+ | BeGambleAware.org<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs 49ers: 2026 form so far<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">One side converts nearly everything and the other converts almost nothing. The table sets each attack against what the opposite defence has allowed.<\/p>\n\n\n\n<h3>Cardinals attack against the 49ers defence<\/h3>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Per game<\/th><th>Cardinals offence<\/th><th>49ers allow<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Passing yards<\/td><td>179.0<\/td><td>175.0<\/td><\/tr>\n<tr><td>Rushing yards<\/td><td>93.0<\/td><td>112.0<\/td><\/tr>\n<tr><td>Yards per carry<\/td><td>3.6<\/td><td>3.9<\/td><\/tr>\n<tr><td>Passer rating<\/td><td>86.2<\/td><td>80.9<\/td><\/tr>\n<tr><td>Touchdowns<\/td><td>1.5<\/td><td>1.0<\/td><\/tr>\n<tr><td>Third-down conversion<\/td><td>34.6%<\/td><td>37.5%<\/td><\/tr>\n<tr><td>Red-zone conversion<\/td><td>50.0%<\/td><td>20.0%<\/td><\/tr>\n<tr><td>Sacks conceded \/ recorded<\/td><td>1.5<\/td><td>2.0<\/td><\/tr>\n<\/tbody><\/table><\/figure>\n<h3>49ers attack against the Cardinals defence<\/h3>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Per game<\/th><th>49ers offence<\/th><th>Cardinals allow<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Passing yards<\/td><td>246.0<\/td><td>203.0<\/td><\/tr>\n<tr><td>Rushing yards<\/td><td>134.5<\/td><td>121.5<\/td><\/tr>\n<tr><td>Yards per carry<\/td><td>4.7<\/td><td>4.0<\/td><\/tr>\n<tr><td>Passer rating<\/td><td>125.6<\/td><td>110.9<\/td><\/tr>\n<tr><td>Touchdowns<\/td><td>4.0<\/td><td>3.0<\/td><\/tr>\n<tr><td>Third-down conversion<\/td><td>63.2%<\/td><td>38.1%<\/td><\/tr>\n<tr><td>Red-zone conversion<\/td><td>87.5%<\/td><td>62.5%<\/td><\/tr>\n<tr><td>Sacks conceded \/ recorded<\/td><td>0.0<\/td><td>2.0<\/td><\/tr>\n<\/tbody><\/table><\/figure>\n<p><em>Read these as a 2-game sample rather than settled form. Rates this early move a long way on one result.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">San Francisco have not conceded a sack all season and score on seven of eight red-zone trips. Arizona have taken 14 penalties for 159 yards.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs 49ers injury report and team news<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Brock Purdy completed 20 of 22 for 287 yards and two touchdowns against Miami at a 149.1 rating, and San Francisco scored on all five red-zone trips.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Jacoby Brissett completed 17 of 28 for 95 yards against Seattle as Arizona held the ball for 23:27.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This section updates as soon as the Out, Doubtful and Questionable tags land.<\/p>\n\n\n\n<!-- SQ_NFL_INJ_START -->\n\n<style>\n.sq-ninj{border:1px solid #123f5c;border-radius:14px;overflow:hidden;margin:24px 0;font-family:'Bricolage Grotesque',system-ui,-apple-system,sans-serif;background:#0a2540;color:#e8f0f7}\n.sq-ninj__head{display:flex;align-items:baseline;justify-content:space-between;gap:10px;padding:13px 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auto;color:rgba(232,240,247,.5);font-size:11px}\n.sq-ninj__st{flex:0 0 auto;font-size:10.5px;font-weight:800;letter-spacing:.04em;text-transform:uppercase;padding:3px 9px;border-radius:999px}\n.sq-ninj__st--out{background:rgba(255,106,90,.16);color:#FF6A5A}\n.sq-ninj__st--doubt{background:rgba(255,194,75,.16);color:#FFC24B}\n.sq-ninj__st--ques{background:rgba(232,240,247,.1);color:rgba(232,240,247,.8)}\n.sq-ninj__st--lt{background:rgba(160,180,200,.14);color:rgba(232,240,247,.82);border:1px solid rgba(232,240,247,.18)}\n.sq-ninj__lt{margin-top:11px;padding-top:9px;border-top:1px solid rgba(255,255,255,.12)}\n.sq-ninj__lt-h{font-size:10px;font-weight:800;letter-spacing:.06em;text-transform:uppercase;color:rgba(232,240,247,.5);margin-bottom:3px}\n.sq-ninj__none{font-size:13px;color:rgba(232,240,247,.55);padding:4px 0}\n@media(max-width:520px){.sq-ninj__col+.sq-ninj__col{border-left:0;border-top:1px solid #123f5c}}\n<\/style><div class=\"sq-ninj\"><div class=\"sq-ninj__head\">Injury report &middot; Week 3<span>Official game-status report &mdash; updates through the week<\/span><\/div><div class=\"sq-ninj__cols\"><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/ARI.png\" alt=\"ARI\" loading=\"lazy\" width=\"24\" height=\"24\">Arizona Cardinals<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><div class=\"sq-ninj__lt\"><div class=\"sq-ninj__lt-h\">Out long-term<\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Kaleb Proctor<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Zach Carter<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Chase Bisontis<\/span><span class=\"sq-ninj__pos\">OL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">James Conner<\/span><span class=\"sq-ninj__pos\">RB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Trey Benson<\/span><span class=\"sq-ninj__pos\">RB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Joey Blount<\/span><span class=\"sq-ninj__pos\">SAF<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Kitan Crawford<\/span><span class=\"sq-ninj__pos\">SAF<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Jameson Geers<\/span><span class=\"sq-ninj__pos\">TE<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Tip Reiman<\/span><span class=\"sq-ninj__pos\">TE<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">PUP<\/span><\/div><\/div><\/div><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"SF\" loading=\"lazy\" width=\"24\" height=\"24\">San Francisco 49ers<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><div class=\"sq-ninj__lt\"><div class=\"sq-ninj__lt-h\">Out long-term<\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Nate Hobbs<\/span><span class=\"sq-ninj__pos\">CB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Alfred Collins<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Andrew Farmer II<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Mikail Kamara<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Sam Okuayinonu<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Nick Martin<\/span><span class=\"sq-ninj__pos\">LB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Austen Pleasants<\/span><span class=\"sq-ninj__pos\">OL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Brett Toth<\/span><span class=\"sq-ninj__pos\">OL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Nick Zakelj<\/span><span class=\"sq-ninj__pos\">OL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Darrick Forrest<\/span><span class=\"sq-ninj__pos\">SAF<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Jake Tonges<\/span><span class=\"sq-ninj__pos\">TE<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Christian Kirk<\/span><span class=\"sq-ninj__pos\">WR<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">De&#8217;Zhaun Stribling<\/span><span class=\"sq-ninj__pos\">WR<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Ricky Pearsall<\/span><span class=\"sq-ninj__pos\">WR<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Mykel Williams<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">PUP<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Isaac Guerendo<\/span><span class=\"sq-ninj__pos\">RB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">PUP<\/span><\/div><\/div><\/div><\/div><\/div>\n\n<!-- SQ_NFL_INJ_END -->\n\n\n\n<h2 class=\"wp-block-heading\">The matchup that settles it: a quarterback nobody has touched<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">No sacks conceded in two games is why Purdy has completed 45 of 56 and thrown five touchdowns.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Arizona&#8217;s problem is everything in front of their own quarterback: 151 yards against Seattle, 3.2 a play, 23 and a half minutes of possession.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Trey McBride is the one route back, having caught eight for 41 and a touchdown in Week 2 against a defence that concedes little.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Players to watch<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Trey McBride (ARI, TE):<\/strong> Eight catches and a touchdown against Seattle.<\/li>\n<li><strong>Jacoby Brissett (ARI, QB):<\/strong> 95 passing yards in Week 2, from 28 attempts.<\/li>\n<li><strong>Brock Purdy (SF, QB):<\/strong> 287 yards and two touchdowns at a 149.1 rating against Miami.<\/li>\n<li><strong>George Kittle (SF, TE):<\/strong> Four catches for 80 yards and a score in Week 2.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to watch Cardinals vs 49ers<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Kickoff is 9.05pm BST on Sunday, September 27, which is 4:05 PM ET in Santa Clara. Sky Sports has the UK coverage and NFL Game Pass on <a href=\"https:\/\/tidd.ly\/3SxpKbx\" rel=\"sponsored nofollow noopener\" target=\"_blank\">DAZN<\/a> carries every game of the season, live or on demand. Sky takes one exclusive pick from each of the Sunday 6pm and 9pm windows, and those two reach Game Pass 24 hours after the final whistle. Squawka may earn a commission if you subscribe through that link.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr><th>Detail<\/th><th>Cardinals vs 49ers<\/th><\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Date<\/strong><\/td><td>Sunday, September 27, 2026<\/td><\/tr>\n<tr><td><strong>Kickoff<\/strong><\/td><td>9.05pm BST \/ Sunday 27 Sep<\/td><\/tr>\n<tr><td><strong>Venue<\/strong><\/td><td>Levi&#8217;s Stadium, Santa Clara, CA<\/td><\/tr>\n<tr><td><strong>TV<\/strong><\/td><td>Sky Sports<\/td><\/tr>\n<tr><td><strong>Live stream<\/strong><\/td><td><a href=\"https:\/\/tidd.ly\/3SxpKbx\" rel=\"sponsored nofollow noopener\" target=\"_blank\">NFL Game Pass (DAZN)<\/a><\/td><\/tr>\n<tr><td><strong>Week<\/strong><\/td><td>Week 2, 2026 NFL season<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs 49ers prediction and score projection<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Our <strong>Cardinals vs 49ers prediction<\/strong> is a San Francisco win, 30-13. The 49ers are efficient everywhere and Arizona could not move the ball at home last week.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The live win probability updates on this page through the week.<\/p>\n\n\n\n<h2>Every Week 3 game, previewed<\/h2>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Kickoff (BST)<\/th><th>Game<\/th><th>Our prediction<\/th><th>Preview<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Fri 1:15 AM<\/td><td>Falcons @ Packers<\/td><td>Packers 23-10<\/td><td><a href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/falcons-vs-packers-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 6:00 PM<\/td><td>Panthers @ Browns<\/td><td>Panthers 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/panthers-vs-browns-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 6:00 PM<\/td><td>Bengals @ Steelers<\/td><td>Bengals 20-13<\/td><td><a href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/bengals-vs-steelers-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 6:00 PM<\/td><td>Texans @ Colts<\/td><td>Colts 26-20<\/td><td><a href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/texans-vs-colts-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 6:00 PM<\/td><td>Chiefs @ Dolphins<\/td><td>Chiefs 31-17<\/td><td><a href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/chiefs-vs-dolphins-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 6:00 PM<\/td><td>Chargers @ Bills<\/td><td>Bills 31-20<\/td><td><a href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/chargers-vs-bills-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 6:00 PM<\/td><td>Patriots @ Jaguars<\/td><td>Patriots 20-16<\/td><td><a href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/patriots-vs-jaguars-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 6:00 PM<\/td><td>Jets @ Lions<\/td><td>Lions 27-20<\/td><td><a href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/jets-vs-lions-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 6:00 PM<\/td><td>Seahawks @ Commanders<\/td><td>Seahawks 27-17<\/td><td><a href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/seahawks-vs-commanders-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 6:00 PM<\/td><td>Titans @ Giants<\/td><td>Titans 20-17<\/td><td><a href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/titans-vs-giants-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 9:05 PM<\/td><td><strong>Cardinals @ 49ers<\/strong><\/td><td>49ers 30-13<\/td><td><em>You are here<\/em><\/td><\/tr>\n<tr><td>Sun 9:05 PM<\/td><td>Vikings @ Buccaneers<\/td><td>Vikings 20-17<\/td><td><a href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/vikings-vs-buccaneers-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 9:25 PM<\/td><td>Ravens @ Cowboys<\/td><td>Ravens 30-24<\/td><td><a href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/ravens-vs-cowboys-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 9:25 PM<\/td><td>Raiders @ Saints<\/td><td>Raiders 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/raiders-vs-saints-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Mon 1:20 AM<\/td><td>Rams @ Broncos<\/td><td>Rams 26-17<\/td><td><a href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/rams-vs-broncos-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Tue 1:15 AM<\/td><td>Eagles @ Bears<\/td><td>Eagles 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/eagles-vs-bears-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Every fixture in the round is covered across our <a href=\"\/en\/nfl\/\">NFL UK hub<\/a>, and the 32 club pages sit on the <a href=\"\/en\/nfl\/teams\/\">NFL teams hub<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs 49ers FAQ<\/h2>\n\n\n\n<div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-arisf-1\"><strong class=\"schema-faq-question\">Who is favoured to win, the Cardinals or the 49ers?<\/strong> <p class=\"schema-faq-answer\">San Francisco, at home and heavily. The 49ers are 2-0 with eight touchdowns; Arizona gained 151 yards last week.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-arisf-2\"><strong class=\"schema-faq-question\">What time is Cardinals vs 49ers in the UK?<\/strong> <p class=\"schema-faq-answer\">9.05pm BST on Sunday, September 27, which is 4:05 PM ET.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-arisf-3\"><strong class=\"schema-faq-question\">Is Cardinals vs 49ers on TV in the UK?<\/strong> <p class=\"schema-faq-answer\">Sky Sports has the coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Sky holds one exclusive pick in each of the Sunday 6pm and 9pm windows, and those two reach Game Pass 24 hours after the final whistle. Channel 5 and 5ACTION show two games free-to-air every Sunday, and those are not blacked out.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-arisf-4\"><strong class=\"schema-faq-question\">Have San Francisco really not conceded a sack?<\/strong> <p class=\"schema-faq-answer\">None in two games, which is a large part of why Purdy is completing 80% of his throws.<\/p><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>18+ | Please gamble responsibly | BeGambleAware.org | Signal probabilities approximate at time of writing and subject to change<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our Cardinals vs 49ers prediction follows a San Francisco side that has not let anyone near its quarterback. Squawka Signal&#8217;s live read updates on this page through the week. The San Francisco 49ers have conceded no sacks in two games, converted 63.2% of their third downs and scored on 87.5% of their red-zone trips. The&#8230;<\/p>\n","protected":false},"author":394,"featured_media":1496112,"menu_order":0,"template":"","meta":{"_acf_changed":false,"_yoast_wpseo_focuskw":"cardinals vs 49ers prediction","_yoast_wpseo_title":"Cardinals vs 49ers Prediction & Tips | Squawka","_yoast_wpseo_metadesc":"Our Cardinals vs 49ers prediction and tips for a 9.05pm BST Sunday at Levi's. San Francisco have not conceded a sack this season.","footnotes":""},"tags":[27546,26951,27545],"class_list":["post-1496153","nfl-news","type-nfl-news","status-publish","has-post-thumbnail","hentry","tag-arizona-cardinals","tag-nfl","tag-san-francisco-49ers"],"acf":{"external_featured_image_url":"","hide_featured_image_pattern":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Cardinals vs 49ers Prediction &amp; Tips | Squawka<\/title>\n<meta name=\"description\" content=\"Our Cardinals vs 49ers prediction and tips for a 9.05pm BST Sunday at Levi&#039;s. 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San Francisco have not conceded a sack this season.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/cardinals-vs-49ers-prediction-picks-odds-week-3\/\" \/>\n<meta property=\"og:site_name\" content=\"Squawka | EN\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SquawkaFootballNews\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-22T17:05:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/media.squawka.com\/images\/2026\/09\/22173447\/wk3-en-preview-cardinals-49ers.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2400\" \/>\n\t<meta property=\"og:image:height\" content=\"1260\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@squawka\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/cardinals-vs-49ers-prediction-picks-odds-week-3\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/cardinals-vs-49ers-prediction-picks-odds-week-3\\\/\"},\"author\":{\"name\":\"Tom Dutton\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/#\\\/schema\\\/person\\\/dc09c06d049425cf5fe14094195dd949\"},\"headline\":\"Cardinals vs 49ers Prediction &#038; Tips\",\"datePublished\":\"2026-09-22T17:05:53+00:00\",\"dateModified\":\"2026-09-22T17:05:54+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/cardinals-vs-49ers-prediction-picks-odds-week-3\\\/\"},\"wordCount\":1213,\"image\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/cardinals-vs-49ers-prediction-picks-odds-week-3\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/media.squawka.com\\\/images\\\/2026\\\/09\\\/22173447\\\/wk3-en-preview-cardinals-49ers.jpg\",\"keywords\":[\"Arizona Cardinals\",\"NFL\",\"San Francisco 49ers\"],\"inLanguage\":\"en-GB\"},{\"@type\":[\"WebPage\",\"FAQPage\"],\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/cardinals-vs-49ers-prediction-picks-odds-week-3\\\/\",\"url\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/cardinals-vs-49ers-prediction-picks-odds-week-3\\\/\",\"name\":\"Cardinals vs 49ers Prediction & Tips | Squawka\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/cardinals-vs-49ers-prediction-picks-odds-week-3\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/cardinals-vs-49ers-prediction-picks-odds-week-3\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/media.squawka.com\\\/images\\\/2026\\\/09\\\/22173447\\\/wk3-en-preview-cardinals-49ers.jpg\",\"datePublished\":\"2026-09-22T17:05:53+00:00\",\"dateModified\":\"2026-09-22T17:05:54+00:00\",\"description\":\"Our Cardinals vs 49ers prediction and tips for a 9.05pm BST Sunday at Levi's. 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