{"id":1493995,"date":"2026-09-15T12:01:49","date_gmt":"2026-09-15T11:01:49","guid":{"rendered":"https:\/\/www.squawka.com\/en\/?post_type=nfl-news&#038;p=1493995"},"modified":"2026-09-15T12:35:59","modified_gmt":"2026-09-15T11:35:59","slug":"lions-vs-bills-prediction-picks-odds-week-2","status":"publish","type":"nfl-news","link":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/lions-vs-bills-prediction-picks-odds-week-2\/","title":{"rendered":"Lions vs Bills Prediction &#038; Tips: Week 2"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Our <strong>Lions vs Bills prediction<\/strong> points to Buffalo, though British viewers will need an alarm: this one kicks off at 1.15am on Friday morning. Squawka Signal&#8217;s live read on the game updates on this page through the week.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It is worth the sleep, mind. The <a href=\"https:\/\/www.squawka.com\/en\/nfl\/teams\/buffalo-bills\/\">Buffalo Bills<\/a> open their new stadium having just put 36 points on Houston from 52 plays, and the <a href=\"https:\/\/www.squawka.com\/en\/nfl\/teams\/detroit-lions\/\">Detroit Lions<\/a> arrive unbeaten after edging New Orleans by a single point. Both are 1-0; neither got there the same way.<\/p>\n\n\n\n<!-- SQ_NFL_SIG_START -->\n\n<style>\n.sq-nsig{position:relative;overflow:hidden;border-radius:18px;margin:28px 0;isolation:isolate;background:radial-gradient(70% 90% at 18% 0%,rgba(47,230,201,.14) 0%,rgba(47,230,201,0) 60%),linear-gradient(135deg,#0a2540 0%,#06182b 60%,#040f1d 100%);box-shadow:0 18px 44px rgba(4,15,29,.5);font-family:'Bricolage 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a{color:#2FE6C9;text-decoration:underline}\n@media(max-width:560px){.sq-nsig__inner{padding:22px 16px}.sq-nsig__cmp{gap:10px}.sq-nsig__verd{min-width:0}.sq-nsig__name{font-size:14px}}\n.sq-nsig__geo-r{position:absolute;width:0;height:0;opacity:0;pointer-events:none}\n.sq-nsig__geo-tabs{display:inline-flex;border:1px solid rgba(47,230,201,.4);border-radius:999px;overflow:hidden;margin:0 0 14px}\n.sq-nsig__geo-tab{cursor:pointer;padding:6px 15px;font-size:11px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:rgba(232,240,247,.6)}\n.sq-nsig__geo-a{display:contents}.sq-nsig__geo-b{display:none}\n.sq-nsig__geo-r--a:checked~.sq-nsig__geo-tabs .sq-nsig__geo-tab--a,.sq-nsig__geo-r--b:checked~.sq-nsig__geo-tabs .sq-nsig__geo-tab--b{background:#2FE6C9;color:#04121f}\n.sq-nsig__geo-r--b:checked~.sq-nsig__cards .sq-nsig__geo-a,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-a{display:none}\n.sq-nsig__geo-r--b:checked~.sq-nsig__cards .sq-nsig__geo-b,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-b{display:contents}\n<\/style>\n<div class=\"sq-nsig\"><div class=\"sq-nsig__inner\"><span class=\"sq-nsig__tag\"><span class=\"dot\"><\/span>Squawka Signal &middot; Model read<\/span><h3 class=\"sq-nsig__title\">Detroit Lions @ Buffalo Bills<\/h3><p class=\"sq-nsig__meta\">Week 2 &middot; Thu Sep 17, 8:15 PM ET. Our Signal model makes the <b>Buffalo Bills<\/b> favourites by about <b>5<\/b> points, a 67% win probability.<\/p><div class=\"sq-nsig__cards\"><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/DET.png\" alt=\"DET\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">Detroit Lions<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Win prob<\/span><span class=\"sq-nsig__cmp-sig\">33%<\/span><\/span><\/span><\/div><\/div><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/BUF.png\" alt=\"BUF\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">Buffalo Bills<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Win prob<\/span><span class=\"sq-nsig__cmp-sig\">67%<\/span><\/span><\/span><\/div><\/div><\/div><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Projected line<\/span><span class=\"sq-nsig__mc-v\">Buffalo Bills -5<\/span><\/div><div class=\"sq-nsig__cta-row\" style=\"margin-top:14px\"><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/boylesports?q=gb-nfl-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">BoyleSports<\/a><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/bet365?q=gb-nfl-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">bet365<\/a><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/sky-bet?q=gb-nfl-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">Sky Bet<\/a><\/div><p class=\"sq-nsig__foot\">Squawka Signal is our model&#8217;s read, updated after every result &mdash; not betting advice. <a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/nfl-signal-methodology\/\">How the NFL Signal works<\/a>. 18+. 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palette matched to the injected sq-nsig Signal units *\/\n.sqp{--cy:#2FE6C9;--val:#38D97A;--ovr:#FF6A5A;--fair:#FFC24B;--tx:#e8f0f7;--mut:rgba(232,240,247,.60);--line:rgba(255,255,255,.10);--gold:#FFC24B;position:relative;overflow:hidden;font-family:'Bricolage Grotesque',system-ui,-apple-system,Segoe UI,Roboto,sans-serif;color:var(--tx);max-width:960px;margin:14px auto 26px;border-radius:14px;background:linear-gradient(135deg,#0a2540 0%,#06182b 62%,#04121f 100%);box-shadow:0 14px 36px rgba(4,18,31,.34)}\n.sqp *{box-sizing:border-box}\n.sqp__wrap{padding:22px 26px 20px}\n.sqp__kick{display:inline-flex;align-items:center;gap:8px;font-size:11px;font-weight:800;letter-spacing:.14em;text-transform:uppercase;color:var(--cy)}\n.sqp__kick::before{content:'';width:7px;height:7px;border-radius:50%;background:var(--cy);box-shadow:0 0 9px 1px var(--cy)}\n.sqp__ttl{font-size:24px;font-weight:800;letter-spacing:-.3px;line-height:1.14;margin:12px 0 0;color:var(--tx)}\n.sqp__sub{margin:7px 0 0;font-size:14.5px;line-height:1.5;color:var(--mut);max-width:70ch}\n.sqp__crests{display:flex;align-items:center;gap:10px;margin-top:14px}\n.sqp__crests img{width:28px;height:28px;display:block}\n.sqp__at{font-size:12px;font-weight:700;color:var(--mut);letter-spacing:.1em}\n.sqp__h3{margin:20px 0 0;font-size:10.5px;font-weight:800;letter-spacing:.16em;text-transform:uppercase;color:var(--cy)}\n.sqp__list{margin-top:12px;border-top:1px solid var(--line)}\n.sqp__row{display:grid;grid-template-columns:1fr 126px;gap:14px;align-items:center;padding:14px 2px;border-bottom:1px solid var(--line)}\n.sqp__mkt{display:block;font-size:10px;font-weight:800;letter-spacing:.13em;text-transform:uppercase;color:var(--cy);margin-bottom:4px}\n.sqp__pk{font-size:15.5px;font-weight:800;line-height:1.25;color:var(--tx)}\n.sqp__top{display:inline-block;vertical-align:middle;margin-left:8px;font-size:9.5px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:#3a2c00;background:var(--gold);padding:3px 7px;border-radius:5px}\n.sqp__why{display:block;margin-top:5px;font-size:13.5px;line-height:1.5;color:var(--mut)}\n.sqp__pr{text-align:center}\n.sqp__val{display:block;font-size:23px;font-weight:800;color:var(--cy);line-height:1;text-decoration:none}\na.sqp__val:hover{text-decoration:underline}\n.sqp__stars{display:block;font-size:15px;line-height:1;letter-spacing:1px;color:var(--gold)}\n.sqp__stars .d{opacity:.24}\n.sqp__lab{display:block;font-size:10px;letter-spacing:.06em;text-transform:uppercase;color:var(--mut);margin-top:4px}\n.sqp__verd{display:inline-block;margin-top:6px;font-size:10.5px;font-weight:800;letter-spacing:.04em;padding:2px 7px;border-radius:5px}\n.sqp__verd--val{color:var(--val);background:rgba(56,217,122,.12)}\n.sqp__verd--ovr{color:var(--ovr);background:rgba(255,106,90,.12)}\n.sqp__verd--fair{color:var(--fair);background:rgba(255,194,75,.12)}\n.sqp__approach{margin:14px 0 0;font-size:13.5px;line-height:1.55;color:var(--tx)}\n.sqp__foot{margin:16px 0 0;padding-top:13px;border-top:1px solid var(--line);font-size:11.5px;line-height:1.55;color:rgba(232,240,247,.5)}\n.sqp__foot a{color:var(--cy);font-weight:700;text-decoration:none;border-bottom:1px solid rgba(47,230,201,.35)}\n@media(max-width:640px){\n.sqp__wrap{padding:18px 15px 16px}\n.sqp__ttl{font-size:20px}\n.sqp__row{grid-template-columns:1fr 100px;gap:10px}\n.sqp__val{font-size:20px}\n}\n<\/style>\n<div class=\"sqp\" id=\"sqp-detbuf\">\n<div class=\"sqp__wrap\">\n<span class=\"sqp__kick\">Week 1 &middot; Editorial pick<\/span>\n<h2 class=\"sqp__ttl\">Lions vs Bills: our editor&#8217;s props<\/h2>\n<p class=\"sqp__sub\">Two editorial calls to sit alongside the live Signal numbers on this page.<\/p>\n<div class=\"sqp__crests\">\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/en\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/DET.png\" alt=\"Lions\" loading=\"lazy\" width=\"28\" height=\"28\">\n<span class=\"sqp__at\">AT<\/span>\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/en\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/BUF.png\" alt=\"Bills\" loading=\"lazy\" width=\"28\" height=\"28\">\n<\/div>\n<h3 class=\"sqp__h3\">Our props<\/h3>\n<div class=\"sqp__list\">\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"Josh Allen 2+ passing touchdowns\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">Josh Allen 2+ passing touchdowns<\/span><span class=\"sqp__why\">Allen threw two against Houston at a 130.5 rating. Meanwhile Detroit conceded 410 passing yards and three scores to Tyler Shough in Week 1.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 4 of 5\">&#9733;&#9733;&#9733;&#9733;<span class=\"d\">&#9733;<\/span><\/span><span class=\"sqp__lab\">confidence<\/span><\/div>\n<\/div>\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"Jahmyr Gibbs 90+ rushing yards\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">Jahmyr Gibbs 90+ rushing yards<\/span><span class=\"sqp__why\">Gibbs carried 29 times for 156 yards and two touchdowns in the opener. Buffalo allowed 124 on the ground to Houston at 3.9 a carry.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 3 of 5\">&#9733;&#9733;&#9733;<span class=\"d\">&#9733;&#9733;<\/span><\/span><span class=\"sqp__lab\">confidence<\/span><\/div>\n<\/div>\n<\/div>\n<p class=\"sqp__foot\">An editorial call, not a Signal model output. 18+ | BeGambleAware.org<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Lions vs Bills: 2026 form so far<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A single game apiece, so the table is a starting point rather than a verdict. The shape of the two wins is the interesting part.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th>2026 season to date<\/th>\n<th class=\"has-text-align-center\" data-align=\"center\">Lions<\/th>\n<th class=\"has-text-align-center\" data-align=\"center\">Bills<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Record<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">1-0<\/td><td class=\"has-text-align-center\" data-align=\"center\">1-0<\/td><\/tr>\n<tr><td><strong>Points for<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">31<\/td><td class=\"has-text-align-center\" data-align=\"center\">36<\/td><\/tr>\n<tr><td><strong>Points against<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">30<\/td><td class=\"has-text-align-center\" data-align=\"center\">31<\/td><\/tr>\n<tr><td><strong>Point differential<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">+1<\/td><td class=\"has-text-align-center\" data-align=\"center\">+5<\/td><\/tr>\n<tr><td><strong>Total yards<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">369<\/td><td class=\"has-text-align-center\" data-align=\"center\">409<\/td><\/tr>\n<tr><td><strong>Yards per play<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">5.1<\/td><td class=\"has-text-align-center\" data-align=\"center\">7.9<\/td><\/tr>\n<tr><td><strong>Turnovers<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">1<\/td><td class=\"has-text-align-center\" data-align=\"center\">0<\/td><\/tr>\n<tr><td><strong>Third-down offence<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">38.5%<\/td><td class=\"has-text-align-center\" data-align=\"center\">33.3%<\/td><\/tr>\n<tr><td><strong>Red-zone offence<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">80.0%<\/td><td class=\"has-text-align-center\" data-align=\"center\">33.3%<\/td><\/tr>\n<tr><td><strong>Sacks recorded<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">5<\/td><td class=\"has-text-align-center\" data-align=\"center\">3<\/td><\/tr>\n<tr><td><strong>Opponent passer rating<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">87.6<\/td><td class=\"has-text-align-center\" data-align=\"center\">106.7<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Buffalo averaged 7.9 yards a play, Detroit 5.1. Detroit, however, held the ball 13 minutes longer, which is how they survived a New Orleans side that gained 469 yards.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Lions vs Bills injury report and team news<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Thursday is the first regular-season game at the new Highmark Stadium, a 60,108-seat ground that replaces the one across the road. Buffalo opened the season in Houston.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This section updates as soon as the Out, Doubtful and Questionable tags land. A Thursday fixture compresses the practice week, so the picture firms up late.<\/p>\n\n\n\n<!-- SQ_NFL_INJ_START -->\n\n<style>\n.sq-ninj{border:1px solid #123f5c;border-radius:14px;overflow:hidden;margin:24px 0;font-family:'Bricolage Grotesque',system-ui,-apple-system,sans-serif;background:#0a2540;color:#e8f0f7}\n.sq-ninj__head{display:flex;align-items:baseline;justify-content:space-between;gap:10px;padding:13px 16px;background:#06182b;font-weight:800;font-size:13px;letter-spacing:.4px;text-transform:uppercase;color:#fff;border-bottom:1px solid #123f5c}\n.sq-ninj__head span{font-size:11px;font-weight:600;letter-spacing:0;text-transform:none;color:rgba(232,240,247,.6)}\n.sq-ninj__cols{display:flex;flex-wrap:wrap}\n.sq-ninj__col{flex:1 1 260px;padding:14px 16px}\n.sq-ninj__col+.sq-ninj__col{border-left:1px solid #123f5c}\n.sq-ninj__team{display:flex;align-items:center;gap:9px;font-weight:800;font-size:14px;color:#fff;margin-bottom:10px}\n.sq-ninj__team img{width:24px;height:24px;object-fit:contain}\n.sq-ninj__row{display:flex;align-items:center;gap:8px;padding:6px 0;border-top:1px solid rgba(255,255,255,.06);font-size:13.5px}\n.sq-ninj__nm{flex:1;min-width:0;color:#fff;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}\n.sq-ninj__pos{flex:0 0 auto;color:rgba(232,240,247,.55);font-size:11px;font-weight:700}\n.sq-ninj__st{flex:0 0 auto;font-size:10.5px;font-weight:800;letter-spacing:.04em;text-transform:uppercase;padding:3px 9px;border-radius:999px}\n.sq-ninj__st--out{background:rgba(255,106,90,.16);color:#FF6A5A}\n.sq-ninj__st--doubt{background:rgba(255,194,75,.16);color:#FFC24B}\n.sq-ninj__st--ques{background:rgba(232,240,247,.1);color:rgba(232,240,247,.8)}\n.sq-ninj__none{font-size:13px;color:rgba(232,240,247,.55);padding:4px 0}\n@media(max-width:520px){.sq-ninj__col+.sq-ninj__col{border-left:0;border-top:1px solid #123f5c}}\n<\/style><div class=\"sq-ninj\"><div class=\"sq-ninj__head\">Injury report &middot; Week 2<span>Official game-status report &mdash; updates through the week<\/span><\/div><div class=\"sq-ninj__cols\"><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/DET.png\" alt=\"DET\" loading=\"lazy\" width=\"24\" height=\"24\">Detroit Lions<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><\/div><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/BUF.png\" alt=\"BUF\" loading=\"lazy\" width=\"24\" height=\"24\">Buffalo Bills<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><\/div><\/div><\/div>\n\n<!-- SQ_NFL_INJ_END -->\n\n\n\n<h2 class=\"wp-block-heading\">The matchup that settles it: Allen against a leaking secondary<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Detroit conceded 410 passing yards to Tyler Shough on Sunday. Josh Allen is a different proposition entirely, and he added two rushing touchdowns to his two through the air.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Against that, Jahmyr Gibbs carried 29 times in the opener. Detroit ran 33 times in all and held possession for 36:51, which is the template they will want again.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Detroit&#8217;s front is no passenger either, having managed five sacks and two interceptions. Buffalo, though, conceded only two sacks and gave the ball away not once.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Players to watch<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Jahmyr Gibbs (DET, RB):<\/strong> 29 carries for 156 yards and two touchdowns in the opener.<\/li>\n<li><strong>Amon-Ra St. Brown (DET, WR):<\/strong> Ten catches and two touchdowns against New Orleans.<\/li>\n<li><strong>Josh Allen (BUF, QB):<\/strong> 334 passing yards at a 130.5 rating, plus two rushing scores.<\/li>\n<li><strong>Dalton Kincaid (BUF, TE):<\/strong> Five catches for 130 yards, the highest total on either side.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to watch Lions vs Bills<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Kickoff is 1.15am BST on Friday, September 18, which is 8:15 PM ET on the Thursday evening in New York. Sky Sports has the coverage and NFL Game Pass on <a href=\"https:\/\/tidd.ly\/3SxpKbx\" rel=\"sponsored nofollow noopener\" target=\"_blank\">DAZN<\/a> carries it. It is the only game of the night, so there is nothing to clash with. Squawka may earn a commission if you subscribe through that link.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr><th>Detail<\/th><th>Lions vs Bills<\/th><\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Date<\/strong><\/td><td>Thursday, September 17, 2026<\/td><\/tr>\n<tr><td><strong>Kickoff<\/strong><\/td><td>1:15am BST Fri 18 Sep \/ 8:15 PM ET Thu 17 Sep<\/td><\/tr>\n<tr><td><strong>Venue<\/strong><\/td><td>Highmark Stadium, Orchard Park, NY<\/td><\/tr>\n<tr><td><strong>TV<\/strong><\/td><td>Sky Sports<\/td><\/tr>\n<tr><td><strong>Live stream<\/strong><\/td><td><a href=\"https:\/\/tidd.ly\/3SxpKbx\" rel=\"sponsored nofollow noopener\" target=\"_blank\">NFL Game Pass (DAZN)<\/a><\/td><\/tr>\n<tr><td><strong>Week<\/strong><\/td><td>Week 2, 2026 NFL season<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Lions vs Bills prediction and score projection<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Our <strong>Lions vs Bills prediction<\/strong> is a Buffalo win, 30-24. Allen against that secondary is the cleanest edge on the card, and the new ground should be loud.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Detroit will run it and Gibbs is good enough to keep this tight. The live win probability updates on this page through the week.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Every fixture in the round is covered across our <a href=\"\/en\/nfl\/\">NFL UK hub<\/a>, and the 32 club pages sit on the <a href=\"\/en\/nfl\/teams\/\">NFL teams hub<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Lions vs Bills FAQ<\/h2>\n\n\n\n<div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-detbuf-1\"><strong class=\"schema-faq-question\">Who is favoured to win, the Lions or the Bills?<\/strong> <p class=\"schema-faq-answer\">Buffalo, at home. Both sides are 1-0, but the Bills averaged 7.9 yards a play in their opener against Detroit&#8217;s 5.1.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-detbuf-2\"><strong class=\"schema-faq-question\">What time is Lions vs Bills in the UK?<\/strong> <p class=\"schema-faq-answer\">1.15am BST on Friday, September 18, which is 8:15 PM ET on the Thursday evening.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-detbuf-3\"><strong class=\"schema-faq-question\">Is Lions vs Bills on TV in the UK?<\/strong> <p class=\"schema-faq-answer\">Sky Sports has the coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Night games are never subject to the UK blackout.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-detbuf-4\"><strong class=\"schema-faq-question\">Is this the first game at the new Highmark Stadium?<\/strong> <p class=\"schema-faq-answer\">It is the first regular-season game there. Buffalo opened away at Houston, so Thursday night is the ground&#8217;s competitive debut.<\/p><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>18+ | Please gamble responsibly | BeGambleAware.org | Signal probabilities approximate at time of writing and subject to change<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our Lions vs Bills prediction points to Buffalo, though British viewers will need an alarm: this one kicks off at 1.15am on Friday morning. Squawka Signal&#8217;s live read on the game updates on this page through the week. It is worth the sleep, mind. The Buffalo Bills open their new stadium having just put 36&#8230;<\/p>\n","protected":false},"author":394,"featured_media":1493823,"menu_order":0,"template":"","meta":{"_acf_changed":false,"_yoast_wpseo_focuskw":"lions vs bills prediction","_yoast_wpseo_title":"Lions vs Bills Prediction & Tips: Week 2 | Squawka","_yoast_wpseo_metadesc":"Our Lions vs Bills prediction, tips and odds for Thursday night. 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Night games are never subject to the UK blackout.","inLanguage":"en-GB"},"inLanguage":"en-GB"},{"@type":"Question","@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/lions-vs-bills-prediction-picks-odds-week-2\/#faq-detbuf-4","position":4,"url":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/lions-vs-bills-prediction-picks-odds-week-2\/#faq-detbuf-4","name":"Is this the first game at the new Highmark Stadium?","answerCount":1,"acceptedAnswer":{"@type":"Answer","text":"It is the first regular-season game there. Buffalo opened away at Houston, so Thursday night is the ground's competitive debut.","inLanguage":"en-GB"},"inLanguage":"en-GB"}]}},"yoast_title":"Lions vs Bills Prediction & Tips: Week 2 | Squawka","yoast_description":"Our Lions vs Bills prediction, tips and odds for Thursday night. A 1.15am BST kickoff opens the new Highmark Stadium, with both sides 1-0.","yoast_keyword":"lions vs bills prediction","_links":{"self":[{"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/nfl-news\/1493995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/nfl-news"}],"about":[{"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/types\/nfl-news"}],"author":[{"embeddable":true,"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/users\/394"}],"version-history":[{"count":5,"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/nfl-news\/1493995\/revisions"}],"predecessor-version":[{"id":1494165,"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/nfl-news\/1493995\/revisions\/1494165"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/media\/1493823"}],"wp:attachment":[{"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/media?parent=1493995"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/tags?post=1493995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}