{"id":1487029,"date":"2026-09-10T18:01:22","date_gmt":"2026-09-10T17:01:22","guid":{"rendered":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/"},"modified":"2026-09-11T11:22:22","modified_gmt":"2026-09-11T10:22:22","slug":"49ers-vs-rams-prediction-picks-odds-week-1","status":"publish","type":"nfl-news","link":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/","title":{"rendered":"49ers vs Rams Prediction &#038; Tips: Week 1"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Our <strong>49ers vs Rams prediction<\/strong> leans to Los Angeles in a 1.35am BST start for anyone watching from Britain. Both sides open the <a href=\"\/en\/nfl\/\">2026 NFL season<\/a> here, a night after the league gets going in Seattle. Squawka Signal&#8217;s live read on this game, including where the value sits, is in the block just below.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Both finished 12-5, so the table suggests a coin flip. The scoreboards, however, disagree: Los Angeles scored 518 points, more than any side playing this round, while San Francisco managed 437 behind a defence that never really turned up.<\/p>\n\n\n\n<!-- SQ_NFL_SIG_START -->\n\n<style>\n.sq-nsig{position:relative;overflow:hidden;border-radius:18px;margin:28px 0;isolation:isolate;background:radial-gradient(70% 90% at 18% 0%,rgba(47,230,201,.14) 0%,rgba(47,230,201,0) 60%),linear-gradient(135deg,#0a2540 0%,#06182b 60%,#040f1d 100%);box-shadow:0 18px 44px rgba(4,15,29,.5);font-family:'Bricolage 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a{color:#2FE6C9;text-decoration:underline}\n@media(max-width:560px){.sq-nsig__inner{padding:22px 16px}.sq-nsig__cmp{gap:10px}.sq-nsig__verd{min-width:0}.sq-nsig__name{font-size:14px}}\n.sq-nsig__geo-r{position:absolute;width:0;height:0;opacity:0;pointer-events:none}\n.sq-nsig__geo-tabs{display:inline-flex;border:1px solid rgba(47,230,201,.4);border-radius:999px;overflow:hidden;margin:0 0 14px}\n.sq-nsig__geo-tab{cursor:pointer;padding:6px 15px;font-size:11px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:rgba(232,240,247,.6)}\n.sq-nsig__geo-a{display:contents}.sq-nsig__geo-b{display:none}\n.sq-nsig__geo-r--a:checked~.sq-nsig__geo-tabs .sq-nsig__geo-tab--a,.sq-nsig__geo-r--b:checked~.sq-nsig__geo-tabs .sq-nsig__geo-tab--b{background:#2FE6C9;color:#04121f}\n.sq-nsig__geo-r--b:checked~.sq-nsig__cards .sq-nsig__geo-a,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-a{display:none}\n.sq-nsig__geo-r--b:checked~.sq-nsig__cards .sq-nsig__geo-b,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-b{display:contents}\n<\/style>\n<div class=\"sq-nsig\"><div class=\"sq-nsig__inner\"><span class=\"sq-nsig__tag\"><span class=\"dot\"><\/span>Squawka Signal &middot; Final<\/span><h3 class=\"sq-nsig__title\">San Francisco 49ers @ Los Angeles Rams<\/h3><p class=\"sq-nsig__meta\">Final score: <b>San Francisco 49ers 27 &ndash; 7 Los Angeles Rams<\/b>. How Squawka Signal&#8217;s pre-game read graded out.<\/p><div style=\"margin-top:4px\"><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Winner<\/span><span class=\"sq-nsig__mc-v\">Signal: Los Angeles Rams (60%)<\/span><span class=\"sq-nsig__verd sq-nsig__verd--over\" style=\"margin-left:12px\">&#10007; Missed<\/span><\/div><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Projected line<\/span><span class=\"sq-nsig__mc-v\">Signal Los Angeles Rams -3 &middot; final margin 20<\/span><\/div><\/div><p class=\"sq-nsig__foot\">Settled result &mdash; Signal&#8217;s pre-game call, locked at kickoff. <a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/nfl-signal-methodology\/\">How the NFL Signal works<\/a>.<\/p><\/div><\/div><!-- SQ_NFL_FINAL -->\n\n\n<!-- sqstore:nfl-match home=los-angeles-rams away=san-francisco-49ers -->\n<div style=\"position:relative;overflow:hidden;border-radius:14px;margin:26px 0;display:flex;flex-wrap:wrap;align-items:stretch;gap:0;min-height:168px;background:linear-gradient(100deg,#0b1e3b,#13284d);color:#fff;font-family:'Bricolage Grotesque',system-ui,-apple-system,Segoe UI,Roboto,sans-serif;\"><div style=\"position:absolute;inset:0;background-image:url(&quot;data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20preserveAspectRatio%3D%22xMidYMid%20slice%22%20viewBox%3D%220%200%203000%203000%22%3E%3Cdefs%3E%3Cpattern%20id%3D%22a%22%20width%3D%2278%22%20height%3D%22175.5%22%20patternTransform%3D%22rotate%28-45%29%22%20patternUnits%3D%22userSpaceOnUse%22%3E%3Cpath%20fill%3D%22%23D50A0A%22%20d%3D%22m-38.22%20157.05-.78-78%2078-.78c.45%2043.12-34.12%2078.33-77.22%2078.78%22%2F%3E%3Cpath%20fill%3D%22%23D50A0A%22%20d%3D%22M77.22%200%2078%2081.6l-78%20.78C-.45%2035.67%2034.12.45%2077.22%200%22%2F%3E%3Cpath%20fill%3D%22%23D50A0A%22%20d%3D%22m37.78%20158.05-.78-78%2078-.78c.45%2043.12-34.12%2078.33-77.22%2078.78%22%2F%3E%3C%2Fpattern%3E%3C%2Fdefs%3E%3Crect%20width%3D%22100%25%22%20height%3D%22100%25%22%20fill%3D%22url%28%23a%29%22%2F%3E%3C%2Fsvg%3E&quot;);background-size:180px 180px;opacity:.13;\"><\/div><div style=\"position:relative;z-index:1;flex:1 1 300px;min-width:0;padding:22px 24px;display:flex;flex-direction:column;justify-content:center;gap:9px;\"><span style=\"display:inline-flex;align-items:center;gap:9px;font-size:11px;font-weight:700;letter-spacing:.14em;text-transform:uppercase;\"><span style=\"background:#D50A0A;color:#fff;padding:3px 8px;border-radius:5px;\">NFL<\/span><span style=\"color:#fff;\">Squawka Store<\/span><\/span><span style=\"font-size:25px;font-weight:800;letter-spacing:-.02em;line-height:1.06;\">Wear the Match<\/span><span style=\"font-size:14px;color:rgba(255,255,255,.78);max-width:42ch;\">Los Angeles Rams vs San Francisco 49ers \u2014 pick up either team\u2019s official jersey, shipped from Fanatics.<\/span><span style=\"font-size:10.5px;color:rgba(255,255,255,.5);margin-top:2px;\">Affiliate links \u2014 Squawka may earn a commission on purchases.<\/span><\/div><div style=\"position:relative;z-index:1;flex:1 1 300px;display:flex;gap:12px;padding:16px 18px;\"><a href=\"https:\/\/fanatics.93n6tx.net\/c\/2650836\/669352\/9663?u=https%3A%2F%2Fwww.fanatics.co.uk%2Fen%2Fnfl%2Flos-angeles-rams&amp;subId1=wear-the-match&amp;subId2=49ers-vs-rams-prediction-picks-odds-week-1&amp;subId3=squawka-en\" target=\"_blank\" rel=\"sponsored nofollow noopener\" style=\"flex:1;min-width:120px;text-decoration:none;display:flex;flex-direction:column;align-items:center;gap:8px;background:#f4f2f6;border-radius:10px;padding:14px 10px 12px;\"><img decoding=\"async\" src=\"https:\/\/feeds.frgimages.com\/_ss5_p-200508767+u-ztkta5guz9kbkzt19tj6+v-jdwta03za5q4rddz4oed.png?_hv=2&amp;w=340\" alt=\"Shop Rams jerseys\" loading=\"lazy\" style=\"width:100%;max-height:118px;object-fit:contain;mix-blend-mode:multiply;\"><span style=\"display:inline-flex;align-items:center;gap:6px;color:#141018;font-weight:800;font-size:12.5px;\">Shop Rams<\/span><\/a><a href=\"https:\/\/fanatics.93n6tx.net\/c\/2650836\/669352\/9663?u=https%3A%2F%2Fwww.fanatics.co.uk%2Fen%2Fnfl%2Fsan-francisco-49ers&amp;subId1=wear-the-match&amp;subId2=49ers-vs-rams-prediction-picks-odds-week-1&amp;subId3=squawka-en\" target=\"_blank\" rel=\"sponsored nofollow noopener\" style=\"flex:1;min-width:120px;text-decoration:none;display:flex;flex-direction:column;align-items:center;gap:8px;background:#f4f2f6;border-radius:10px;padding:14px 10px 12px;\"><img decoding=\"async\" src=\"https:\/\/feeds.frgimages.com\/_ss5_p-203456593+u-zij3mcwthhmbcsrvvrzg+v-se6kh5kli04zyo1rrzeu.png?_hv=2&amp;w=340\" alt=\"Shop 49ers jerseys\" loading=\"lazy\" style=\"width:100%;max-height:118px;object-fit:contain;mix-blend-mode:multiply;\"><span style=\"display:inline-flex;align-items:center;gap:6px;color:#141018;font-weight:800;font-size:12.5px;\">Shop 49ers<\/span><\/a><\/div><\/div>\n<!-- \/sqstore:nfl-match -->\n\n<!-- SQ_NFL_SIG_END -->\n\n\n\n<style>\n\/* Squawka NFL picks card - palette matched to the injected sq-nsig Signal units *\/\n.sqp{--cy:#2FE6C9;--val:#38D97A;--ovr:#FF6A5A;--fair:#FFC24B;--tx:#e8f0f7;--mut:rgba(232,240,247,.60);--line:rgba(255,255,255,.10);--gold:#FFC24B;position:relative;overflow:hidden;font-family:'Bricolage Grotesque',system-ui,-apple-system,Segoe UI,Roboto,sans-serif;color:var(--tx);max-width:960px;margin:14px auto 26px;border-radius:14px;background:linear-gradient(135deg,#0a2540 0%,#06182b 62%,#04121f 100%);box-shadow:0 14px 36px rgba(4,18,31,.34)}\n.sqp *{box-sizing:border-box}\n.sqp__wrap{padding:22px 26px 20px}\n.sqp__kick{display:inline-flex;align-items:center;gap:8px;font-size:11px;font-weight:800;letter-spacing:.14em;text-transform:uppercase;color:var(--cy)}\n.sqp__kick::before{content:'';width:7px;height:7px;border-radius:50%;background:var(--cy);box-shadow:0 0 9px 1px var(--cy)}\n.sqp__ttl{font-size:24px;font-weight:800;letter-spacing:-.3px;line-height:1.14;margin:12px 0 0;color:var(--tx)}\n.sqp__sub{margin:7px 0 0;font-size:14.5px;line-height:1.5;color:var(--mut);max-width:70ch}\n.sqp__crests{display:flex;align-items:center;gap:10px;margin-top:14px}\n.sqp__crests img{width:28px;height:28px;display:block}\n.sqp__at{font-size:12px;font-weight:700;color:var(--mut);letter-spacing:.1em}\n.sqp__h3{margin:20px 0 0;font-size:10.5px;font-weight:800;letter-spacing:.16em;text-transform:uppercase;color:var(--cy)}\n.sqp__list{margin-top:12px;border-top:1px solid var(--line)}\n.sqp__row{display:grid;grid-template-columns:1fr 126px;gap:14px;align-items:center;padding:14px 2px;border-bottom:1px solid var(--line)}\n.sqp__mkt{display:block;font-size:10px;font-weight:800;letter-spacing:.13em;text-transform:uppercase;color:var(--cy);margin-bottom:4px}\n.sqp__pk{font-size:15.5px;font-weight:800;line-height:1.25;color:var(--tx)}\n.sqp__top{display:inline-block;vertical-align:middle;margin-left:8px;font-size:9.5px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:#3a2c00;background:var(--gold);padding:3px 7px;border-radius:5px}\n.sqp__why{display:block;margin-top:5px;font-size:13.5px;line-height:1.5;color:var(--mut)}\n.sqp__pr{text-align:center}\n.sqp__val{display:block;font-size:23px;font-weight:800;color:var(--cy);line-height:1;text-decoration:none}\na.sqp__val:hover{text-decoration:underline}\n.sqp__stars{display:block;font-size:15px;line-height:1;letter-spacing:1px;color:var(--gold)}\n.sqp__stars .d{opacity:.24}\n.sqp__lab{display:block;font-size:10px;letter-spacing:.06em;text-transform:uppercase;color:var(--mut);margin-top:4px}\n.sqp__verd{display:inline-block;margin-top:6px;font-size:10.5px;font-weight:800;letter-spacing:.04em;padding:2px 7px;border-radius:5px}\n.sqp__verd--val{color:var(--val);background:rgba(56,217,122,.12)}\n.sqp__verd--ovr{color:var(--ovr);background:rgba(255,106,90,.12)}\n.sqp__verd--fair{color:var(--fair);background:rgba(255,194,75,.12)}\n.sqp__approach{margin:14px 0 0;font-size:13.5px;line-height:1.55;color:var(--tx)}\n.sqp__foot{margin:16px 0 0;padding-top:13px;border-top:1px solid var(--line);font-size:11.5px;line-height:1.55;color:rgba(232,240,247,.5)}\n.sqp__foot a{color:var(--cy);font-weight:700;text-decoration:none;border-bottom:1px solid rgba(47,230,201,.35)}\n@media(max-width:640px){\n.sqp__wrap{padding:18px 15px 16px}\n.sqp__ttl{font-size:20px}\n.sqp__row{grid-template-columns:1fr 100px;gap:10px}\n.sqp__val{font-size:20px}\n}\n<\/style>\n<div class=\"sqp\" id=\"sqp-sfla\">\n<div class=\"sqp__wrap\">\n<span class=\"sqp__kick\">Week 1 &middot; Editorial pick<\/span>\n<h2 class=\"sqp__ttl\">49ers vs Rams: our editor&#8217;s prop<\/h2>\n<p class=\"sqp__sub\">One editorial call to sit alongside the live Signal numbers above.<\/p>\n<div class=\"sqp__crests\">\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/en\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"49ers\" loading=\"lazy\" width=\"28\" height=\"28\">\n<span class=\"sqp__at\">AT<\/span>\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/en\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/LA.png\" alt=\"Rams\" loading=\"lazy\" width=\"28\" height=\"28\">\n<\/div>\n<h3 class=\"sqp__h3\">Our prop<\/h3>\n<div class=\"sqp__list\">\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"Matthew Stafford over 2 passing touchdowns\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">Matthew Stafford over 2 passing touchdowns<\/span><span class=\"sqp__why\">Stafford threw 46 touchdown passes in 2025 against only eight interceptions. San Francisco, meanwhile, allowed a 100.5 opponent passer rating and generated almost no pressure.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 4 of 5\">&#9733;&#9733;&#9733;&#9733;<span class=\"d\">&#9733;<\/span><\/span><span class=\"sqp__lab\">confidence<\/span><\/div>\n<\/div>\n<\/div>\n<p class=\"sqp__foot\">An editorial call, not a Signal model output. 18+ | BeGambleAware.org<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">49ers vs Rams: 2025 season form<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Both finished 12-5. Los Angeles carried a plus 172 differential, however, against San Francisco&#8217;s plus 66.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th>2025 regular season<\/th>\n<th class=\"has-text-align-center\" data-align=\"center\">49ers<\/th>\n<th class=\"has-text-align-center\" data-align=\"center\">Rams<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Record<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">12-5<\/td><td class=\"has-text-align-center\" data-align=\"center\">12-5<\/td><\/tr>\n<tr><td><strong>Points for<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">437<\/td><td class=\"has-text-align-center\" data-align=\"center\">518<\/td><\/tr>\n<tr><td><strong>Points against<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">371<\/td><td class=\"has-text-align-center\" data-align=\"center\">346<\/td><\/tr>\n<tr><td><strong>Point differential<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">+66<\/td><td class=\"has-text-align-center\" data-align=\"center\">+172<\/td><\/tr>\n<tr><td><strong>Sacks recorded<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">20<\/td><td class=\"has-text-align-center\" data-align=\"center\">47<\/td><\/tr>\n<tr><td><strong>Sacks allowed<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">27<\/td><td class=\"has-text-align-center\" data-align=\"center\">23<\/td><\/tr>\n<tr><td><strong>Interceptions made<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">6<\/td><td class=\"has-text-align-center\" data-align=\"center\">16<\/td><\/tr>\n<tr><td><strong>Third-down offence<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">49.8%<\/td><td class=\"has-text-align-center\" data-align=\"center\">39.6%<\/td><\/tr>\n<tr><td><strong>Red-zone offence<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">65.2%<\/td><td class=\"has-text-align-center\" data-align=\"center\">63.2%<\/td><\/tr>\n<tr><td><strong>Red zone allowed<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">53.8%<\/td><td class=\"has-text-align-center\" data-align=\"center\">46.2%<\/td><\/tr>\n<tr><td><strong>Opponent passer rating<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">100.5<\/td><td class=\"has-text-align-center\" data-align=\"center\">87.0<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">One row settles it. San Francisco recorded 20 sacks across the whole season, comfortably the fewest of any side in this round, and a 100.5 opponent passer rating followed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">49ers vs Rams injury report and team news<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This section updates as soon as the Out, Doubtful and Questionable tags land. Notably, for now, both sides expect their first-choice quarterbacks.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Matthew Stafford starts for Los Angeles after a league-leading 4,707 passing yards. Puka Nacua heads the receivers, moreover, following 1,715 of his own.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Brock Purdy starts for San Francisco. Christian McCaffrey remains the focal point, meanwhile, after 1,202 rushing yards and 924 through the air.<\/p>\n\n\n\n<!-- SQ_NFL_INJ_START -->\n\n<style>\n.sq-ninj{border:1px solid #123f5c;border-radius:14px;overflow:hidden;margin:24px 0;font-family:'Bricolage Grotesque',system-ui,-apple-system,sans-serif;background:#0a2540;color:#e8f0f7}\n.sq-ninj__head{display:flex;align-items:baseline;justify-content:space-between;gap:10px;padding:13px 16px;background:#06182b;font-weight:800;font-size:13px;letter-spacing:.4px;text-transform:uppercase;color:#fff;border-bottom:1px solid #123f5c}\n.sq-ninj__head span{font-size:11px;font-weight:600;letter-spacing:0;text-transform:none;color:rgba(232,240,247,.6)}\n.sq-ninj__cols{display:flex;flex-wrap:wrap}\n.sq-ninj__col{flex:1 1 260px;padding:14px 16px}\n.sq-ninj__col+.sq-ninj__col{border-left:1px solid #123f5c}\n.sq-ninj__team{display:flex;align-items:center;gap:9px;font-weight:800;font-size:14px;color:#fff;margin-bottom:10px}\n.sq-ninj__team img{width:24px;height:24px;object-fit:contain}\n.sq-ninj__row{display:flex;align-items:center;gap:8px;padding:6px 0;border-top:1px solid rgba(255,255,255,.06);font-size:13.5px}\n.sq-ninj__nm{flex:1;min-width:0;color:#fff;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}\n.sq-ninj__pos{flex:0 0 auto;color:rgba(232,240,247,.55);font-size:11px;font-weight:700}\n.sq-ninj__st{flex:0 0 auto;font-size:10.5px;font-weight:800;letter-spacing:.04em;text-transform:uppercase;padding:3px 9px;border-radius:999px}\n.sq-ninj__st--out{background:rgba(255,106,90,.16);color:#FF6A5A}\n.sq-ninj__st--doubt{background:rgba(255,194,75,.16);color:#FFC24B}\n.sq-ninj__st--ques{background:rgba(232,240,247,.1);color:rgba(232,240,247,.8)}\n.sq-ninj__none{font-size:13px;color:rgba(232,240,247,.55);padding:4px 0}\n@media(max-width:520px){.sq-ninj__col+.sq-ninj__col{border-left:0;border-top:1px solid #123f5c}}\n<\/style><div class=\"sq-ninj\"><div class=\"sq-ninj__head\">Injury report &middot; Week 1<span>Official game-status report &mdash; updates through the week<\/span><\/div><div class=\"sq-ninj__cols\"><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"SF\" loading=\"lazy\" width=\"24\" height=\"24\">San Francisco 49ers<\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Alfred Collins<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--out\">Out<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">James Thompson Jr.<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--ques\">Questionable<\/span><\/div><\/div><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/LA.png\" alt=\"LA\" loading=\"lazy\" width=\"24\" height=\"24\">Los Angeles Rams<\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Aaron Donald<\/span><span class=\"sq-ninj__pos\">DE<\/span><span class=\"sq-ninj__st sq-ninj__st--out\">Out<\/span><\/div><\/div><\/div><\/div>\n\n<!-- SQ_NFL_INJ_END -->\n\n\n\n<h2 class=\"wp-block-heading\">The matchup that settles it: Stafford against a pass rush that never arrived<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">San Francisco recorded 20 sacks in 2025. Notably no other side on this weekend&#8217;s card managed so few.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Stafford threw 46 touchdowns at a 109.0 rating over the same season. Consequently the most lopsided pairing in the round is a quarterback with time against a front that cannot take it away.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Players to watch<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Matthew Stafford (LA, QB):<\/strong> 4,707 passing yards and 46 touchdowns, indeed the most in the league.<\/li>\n<li><strong>Puka Nacua (LA, WR):<\/strong> 1,715 receiving yards, notably second in the league.<\/li>\n<li><strong>Kyren Williams (LA, RB):<\/strong> 1,252 rushing yards behind the round&#8217;s highest-scoring offence.<\/li>\n<li><strong>Christian McCaffrey (SF, RB):<\/strong> 1,202 rushing and 924 receiving yards, moreover, in one season.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to watch 49ers vs Rams<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Kickoff is 8:35 PM ET on Thursday, September 10, or <strong>1:35am BST on the Friday<\/strong> in the UK. Netflix has the broadcast, moreover, with NFL Game Pass on <a href=\"https:\/\/tidd.ly\/3SxpKbx\" rel=\"sponsored nofollow noopener\" target=\"_blank\">DAZN<\/a> carrying it as well. This is one for the insomniacs rather than the after-work crowd. Squawka may earn a commission if you subscribe through that link.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr><th>Detail<\/th><th>49ers vs Rams<\/th><\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Date<\/strong><\/td><td>Thursday, September 10, 2026<\/td><\/tr>\n<tr><td><strong>Kickoff<\/strong><\/td><td>1:35am BST Fri 11 Sep \/ 8:35 PM ET Thu 10 Sep<\/td><\/tr>\n<tr><td><strong>Venue<\/strong><\/td><td>Melbourne Cricket Ground, Australia<\/td><\/tr>\n<tr><td><strong>TV<\/strong><\/td><td>Netflix<\/td><\/tr>\n<tr><td><strong>Live stream<\/strong><\/td><td>NFL Game Pass (DAZN)<\/td><\/tr>\n<tr><td><strong>Week<\/strong><\/td><td>Week 1, 2026 NFL season<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">49ers vs Rams prediction and score projection<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Our <strong>49ers vs Rams prediction<\/strong> is a narrow Los Angeles win. Stafford against a 20-sack pass rush is the most lopsided matchup on the card.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Similarly San Francisco can shorten the game through McCaffrey, and 12-5 was no fluke. Nevertheless the <a href=\"https:\/\/www.squawka.com\/en\/nfl\/teams\/los-angeles-rams\/\">Rams<\/a> scored 81 more points across the season. So we will take the Rams, 27-23. Which side carries the value, though, is a separate question from who wins, and the live read on that sits in the Signal block.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Every fixture in the round is covered across our <a href=\"\/en\/nfl\/\">NFL UK hub<\/a>, and the 32 club pages sit on the <a href=\"\/en\/nfl\/teams\/\">NFL teams hub<\/a>. Kickoff times are confirmed on <a href=\"https:\/\/www.nfl.com\/schedules\/\" rel=\"noopener\" target=\"_blank\">NFL.com<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">49ers vs Rams FAQ<\/h2>\n\n\n\n<div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-sfla-1\"><strong class=\"schema-faq-question\">Who is favourite to win, the <a href=\"https:\/\/www.squawka.com\/en\/nfl\/teams\/san-francisco-49ers\/\">49ers<\/a> or the Rams?<\/strong> <p class=\"schema-faq-answer\">Los Angeles. Both finished 12-5, but the Rams scored 518 points to San Francisco&#8217;s 437 and the 49ers recorded only 20 sacks all season. Ultimately the live win probability sits in the Signal block on this page.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-sfla-2\"><strong class=\"schema-faq-question\">What time is 49ers vs Rams in the UK?<\/strong> <p class=\"schema-faq-answer\">1.35am BST on Friday 11 September, which is 8:35 PM ET on the Thursday.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-sfla-3\"><strong class=\"schema-faq-question\">How can I watch 49ers vs Rams in the UK?<\/strong> <p class=\"schema-faq-answer\">Netflix has the broadcast and NFL Game Pass on DAZN carries it as well. Kickoff is 1.35am BST on Friday 11 September.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-sfla-4\"><strong class=\"schema-faq-question\">Who starts at quarterback for the Rams?<\/strong> <p class=\"schema-faq-answer\">Matthew Stafford, who threw for 4,707 yards and 46 touchdowns in 2025. Meanwhile Brock Purdy starts for San Francisco.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-sfla-5\"><strong class=\"schema-faq-question\">What is the score prediction for 49ers vs Rams?<\/strong> <p class=\"schema-faq-answer\">Rams 27-23. Los Angeles brought the higher-scoring offence and San Francisco&#8217;s 20 sacks were the fewest of any side in this round.<\/p><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>18+ | Please gamble responsibly | BeGambleAware.org | Signal probabilities approximate at time of writing and subject to change<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our 49ers vs Rams prediction leans to Los Angeles in a 1.35am BST start for anyone watching from Britain. Both sides open the 2026 NFL season here, a night after the league gets going in Seattle. Squawka Signal&#8217;s live read on this game, including where the value sits, is in the block just below. Both&#8230;<\/p>\n","protected":false},"author":394,"featured_media":1487937,"menu_order":0,"template":"","meta":{"_acf_changed":false,"_yoast_wpseo_focuskw":"49ers vs rams prediction","_yoast_wpseo_title":"49ers vs Rams Prediction & Tips: Week 1 | Squawka","_yoast_wpseo_metadesc":"Our 49ers vs Rams prediction, tips and odds for the NFL's first game in Melbourne. Two 12-5 sides, 1.35am BST kickoff on Netflix. 18+.","footnotes":""},"tags":[27538,26951,27545],"class_list":["post-1487029","nfl-news","type-nfl-news","status-publish","has-post-thumbnail","hentry","tag-los-angeles-rams","tag-nfl","tag-san-francisco-49ers"],"acf":{"external_featured_image_url":"","hide_featured_image_pattern":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>49ers vs Rams Prediction &amp; Tips: Week 1 | Squawka<\/title>\n<meta name=\"description\" content=\"Our 49ers vs Rams prediction, tips and odds for the NFL&#039;s first game in Melbourne. 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Los Angeles brought the higher-scoring offence and San Francisco's 20 sacks were the fewest of any side in this round.","inLanguage":"en-GB"},"inLanguage":"en-GB"}]}},"yoast_title":"49ers vs Rams Prediction & Tips: Week 1 | Squawka","yoast_description":"Our 49ers vs Rams prediction, tips and odds for the NFL's first game in Melbourne. 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