{"id":1487029,"date":"2026-09-08T10:12:17","date_gmt":"2026-09-08T09:12:17","guid":{"rendered":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/"},"modified":"2026-09-08T11:14:55","modified_gmt":"2026-09-08T10:14:55","slug":"49ers-vs-rams-prediction-picks-odds-week-1","status":"publish","type":"nfl-news","link":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/","title":{"rendered":"49ers vs Rams Prediction &#038; Tips: Week 1"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Our <strong>49ers vs Rams prediction<\/strong> leans to Los Angeles in a 1.35am BST start for anyone watching from Britain. Both sides open the <a href=\"\/en\/nfl\/\">2026 NFL season<\/a> here, a night after the league gets going in Seattle. Squawka Signal&#8217;s live read on this game, including where the value sits, is in the block just below.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Both finished 12-5, so the table suggests a coin flip. The scoreboards, however, disagree: Los Angeles scored 518 points, more than any side playing this round, while San Francisco managed 437 behind a defence that never really turned up.<\/p>\n\n\n\n<!-- SQ_NFL_SIGNAL -->\n\n\n\n<style>\n\/* Squawka NFL picks card - palette matched to the injected sq-nsig Signal units *\/\n.sqp{--cy:#2FE6C9;--val:#38D97A;--ovr:#FF6A5A;--fair:#FFC24B;--tx:#e8f0f7;--mut:rgba(232,240,247,.60);--line:rgba(255,255,255,.10);--gold:#FFC24B;position:relative;overflow:hidden;font-family:'Bricolage Grotesque',system-ui,-apple-system,Segoe UI,Roboto,sans-serif;color:var(--tx);max-width:960px;margin:14px auto 26px;border-radius:14px;background:linear-gradient(135deg,#0a2540 0%,#06182b 62%,#04121f 100%);box-shadow:0 14px 36px rgba(4,18,31,.34)}\n.sqp *{box-sizing:border-box}\n.sqp__wrap{padding:22px 26px 20px}\n.sqp__kick{display:inline-flex;align-items:center;gap:8px;font-size:11px;font-weight:800;letter-spacing:.14em;text-transform:uppercase;color:var(--cy)}\n.sqp__kick::before{content:'';width:7px;height:7px;border-radius:50%;background:var(--cy);box-shadow:0 0 9px 1px var(--cy)}\n.sqp__ttl{font-size:24px;font-weight:800;letter-spacing:-.3px;line-height:1.14;margin:12px 0 0;color:var(--tx)}\n.sqp__sub{margin:7px 0 0;font-size:14.5px;line-height:1.5;color:var(--mut);max-width:70ch}\n.sqp__crests{display:flex;align-items:center;gap:10px;margin-top:14px}\n.sqp__crests img{width:28px;height:28px;display:block}\n.sqp__at{font-size:12px;font-weight:700;color:var(--mut);letter-spacing:.1em}\n.sqp__h3{margin:20px 0 0;font-size:10.5px;font-weight:800;letter-spacing:.16em;text-transform:uppercase;color:var(--cy)}\n.sqp__list{margin-top:12px;border-top:1px solid var(--line)}\n.sqp__row{display:grid;grid-template-columns:1fr 126px;gap:14px;align-items:center;padding:14px 2px;border-bottom:1px solid var(--line)}\n.sqp__mkt{display:block;font-size:10px;font-weight:800;letter-spacing:.13em;text-transform:uppercase;color:var(--cy);margin-bottom:4px}\n.sqp__pk{font-size:15.5px;font-weight:800;line-height:1.25;color:var(--tx)}\n.sqp__top{display:inline-block;vertical-align:middle;margin-left:8px;font-size:9.5px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:#3a2c00;background:var(--gold);padding:3px 7px;border-radius:5px}\n.sqp__why{display:block;margin-top:5px;font-size:13.5px;line-height:1.5;color:var(--mut)}\n.sqp__pr{text-align:center}\n.sqp__val{display:block;font-size:23px;font-weight:800;color:var(--cy);line-height:1;text-decoration:none}\na.sqp__val:hover{text-decoration:underline}\n.sqp__stars{display:block;font-size:15px;line-height:1;letter-spacing:1px;color:var(--gold)}\n.sqp__stars .d{opacity:.24}\n.sqp__lab{display:block;font-size:10px;letter-spacing:.06em;text-transform:uppercase;color:var(--mut);margin-top:4px}\n.sqp__verd{display:inline-block;margin-top:6px;font-size:10.5px;font-weight:800;letter-spacing:.04em;padding:2px 7px;border-radius:5px}\n.sqp__verd--val{color:var(--val);background:rgba(56,217,122,.12)}\n.sqp__verd--ovr{color:var(--ovr);background:rgba(255,106,90,.12)}\n.sqp__verd--fair{color:var(--fair);background:rgba(255,194,75,.12)}\n.sqp__approach{margin:14px 0 0;font-size:13.5px;line-height:1.55;color:var(--tx)}\n.sqp__foot{margin:16px 0 0;padding-top:13px;border-top:1px solid var(--line);font-size:11.5px;line-height:1.55;color:rgba(232,240,247,.5)}\n.sqp__foot a{color:var(--cy);font-weight:700;text-decoration:none;border-bottom:1px solid rgba(47,230,201,.35)}\n@media(max-width:640px){\n.sqp__wrap{padding:18px 15px 16px}\n.sqp__ttl{font-size:20px}\n.sqp__row{grid-template-columns:1fr 100px;gap:10px}\n.sqp__val{font-size:20px}\n}\n<\/style>\n<div class=\"sqp\" id=\"sqp-sfla\">\n<div class=\"sqp__wrap\">\n<span class=\"sqp__kick\">Week 1 &middot; Editorial pick<\/span>\n<h2 class=\"sqp__ttl\">49ers vs Rams: our editor&#8217;s prop<\/h2>\n<p class=\"sqp__sub\">One editorial call to sit alongside the live Signal numbers above.<\/p>\n<div class=\"sqp__crests\">\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/en\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"49ers\" loading=\"lazy\" width=\"28\" height=\"28\">\n<span class=\"sqp__at\">AT<\/span>\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/en\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/LA.png\" alt=\"Rams\" loading=\"lazy\" width=\"28\" height=\"28\">\n<\/div>\n<h3 class=\"sqp__h3\">Our prop<\/h3>\n<div class=\"sqp__list\">\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"Matthew Stafford over 2 passing touchdowns\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">Matthew Stafford over 2 passing touchdowns<\/span><span class=\"sqp__why\">Stafford threw 46 touchdown passes in 2025 against only eight interceptions. San Francisco, meanwhile, allowed a 100.5 opponent passer rating and generated almost no pressure.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 4 of 5\">&#9733;&#9733;&#9733;&#9733;<span class=\"d\">&#9733;<\/span><\/span><span class=\"sqp__lab\">confidence<\/span><\/div>\n<\/div>\n<\/div>\n<p class=\"sqp__foot\">An editorial call, not a Signal model output. 18+ | BeGambleAware.org<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">49ers vs Rams: 2025 season form<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Both finished 12-5. Los Angeles carried a plus 172 differential, however, against San Francisco&#8217;s plus 66.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th>2025 regular season<\/th>\n<th class=\"has-text-align-center\" data-align=\"center\">49ers<\/th>\n<th class=\"has-text-align-center\" data-align=\"center\">Rams<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Record<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">12-5<\/td><td class=\"has-text-align-center\" data-align=\"center\">12-5<\/td><\/tr>\n<tr><td><strong>Points for<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">437<\/td><td class=\"has-text-align-center\" data-align=\"center\">518<\/td><\/tr>\n<tr><td><strong>Points against<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">371<\/td><td class=\"has-text-align-center\" data-align=\"center\">346<\/td><\/tr>\n<tr><td><strong>Point differential<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">+66<\/td><td class=\"has-text-align-center\" data-align=\"center\">+172<\/td><\/tr>\n<tr><td><strong>Sacks recorded<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">20<\/td><td class=\"has-text-align-center\" data-align=\"center\">47<\/td><\/tr>\n<tr><td><strong>Sacks allowed<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">27<\/td><td class=\"has-text-align-center\" data-align=\"center\">23<\/td><\/tr>\n<tr><td><strong>Interceptions made<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">6<\/td><td class=\"has-text-align-center\" data-align=\"center\">16<\/td><\/tr>\n<tr><td><strong>Third-down offence<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">49.8%<\/td><td class=\"has-text-align-center\" data-align=\"center\">39.6%<\/td><\/tr>\n<tr><td><strong>Red-zone offence<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">65.2%<\/td><td class=\"has-text-align-center\" data-align=\"center\">63.2%<\/td><\/tr>\n<tr><td><strong>Red zone allowed<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">53.8%<\/td><td class=\"has-text-align-center\" data-align=\"center\">46.2%<\/td><\/tr>\n<tr><td><strong>Opponent passer rating<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">100.5<\/td><td class=\"has-text-align-center\" data-align=\"center\">87.0<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">One row settles it. San Francisco recorded 20 sacks across the whole season, comfortably the fewest of any side in this round, and a 100.5 opponent passer rating followed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">49ers vs Rams injury report and team news<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This section updates as soon as the Out, Doubtful and Questionable tags land. Notably, for now, both sides expect their first-choice quarterbacks.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Matthew Stafford starts for Los Angeles after a league-leading 4,707 passing yards. Puka Nacua heads the receivers, moreover, following 1,715 of his own.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Brock Purdy starts for San Francisco. Christian McCaffrey remains the focal point, meanwhile, after 1,202 rushing yards and 924 through the air.<\/p>\n\n\n\n<!-- SQ_NFL_INJURIES -->\n\n\n\n<h2 class=\"wp-block-heading\">The matchup that settles it: Stafford against a pass rush that never arrived<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">San Francisco recorded 20 sacks in 2025. Notably no other side on this weekend&#8217;s card managed so few.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Stafford threw 46 touchdowns at a 109.0 rating over the same season. Consequently the most lopsided pairing in the round is a quarterback with time against a front that cannot take it away.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Players to watch<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Matthew Stafford (LA, QB):<\/strong> 4,707 passing yards and 46 touchdowns, indeed the most in the league.<\/li>\n<li><strong>Puka Nacua (LA, WR):<\/strong> 1,715 receiving yards, notably second in the league.<\/li>\n<li><strong>Kyren Williams (LA, RB):<\/strong> 1,252 rushing yards behind the round&#8217;s highest-scoring offence.<\/li>\n<li><strong>Christian McCaffrey (SF, RB):<\/strong> 1,202 rushing and 924 receiving yards, moreover, in one season.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to watch 49ers vs Rams<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Kickoff is 8:35 PM ET on Thursday, September 10, or <strong>1:35am BST on the Friday<\/strong> in the UK. Sky Sports has the broadcast, moreover, with NFL Game Pass on <a href=\"https:\/\/tidd.ly\/3SxpKbx\" rel=\"sponsored nofollow noopener\" target=\"_blank\">DAZN<\/a> carrying it as well. This is one for the insomniacs rather than the after-work crowd. Squawka may earn a commission if you subscribe through that link.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr><th>Detail<\/th><th>49ers vs Rams<\/th><\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Date<\/strong><\/td><td>Thursday, September 10, 2026<\/td><\/tr>\n<tr><td><strong>Kickoff<\/strong><\/td><td>1:35am BST Fri 11 Sep \/ 8:35 PM ET Thu 10 Sep<\/td><\/tr>\n<tr><td><strong>Venue<\/strong><\/td><td>SoFi Stadium, Inglewood<\/td><\/tr>\n<tr><td><strong>TV<\/strong><\/td><td>Sky Sports<\/td><\/tr>\n<tr><td><strong>Live stream<\/strong><\/td><td>NFL Game Pass (DAZN)<\/td><\/tr>\n<tr><td><strong>Week<\/strong><\/td><td>Week 1, 2026 NFL season<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">49ers vs Rams prediction and score projection<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Our <strong>49ers vs Rams prediction<\/strong> is a narrow Los Angeles win. Stafford against a 20-sack pass rush is the most lopsided matchup on the card.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Similarly San Francisco can shorten the game through McCaffrey, and 12-5 was no fluke. Nevertheless the Rams scored 81 more points across the season. So we will take the Rams, 27-23. Which side carries the value, though, is a separate question from who wins, and the live read on that sits in the Signal block.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Every fixture in the round is covered across our <a href=\"\/en\/nfl\/\">NFL UK hub<\/a>, and the 32 club pages sit on the <a href=\"\/en\/nfl\/teams\/\">NFL teams hub<\/a>. Kickoff times are confirmed on <a href=\"https:\/\/www.nfl.com\/schedules\/\" rel=\"noopener\" target=\"_blank\">NFL.com<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">49ers vs Rams FAQ<\/h2>\n\n\n\n<div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-sfla-1\"><strong class=\"schema-faq-question\">Who is favourite to win, the 49ers or the Rams?<\/strong> <p class=\"schema-faq-answer\">Los Angeles. Both finished 12-5, but the Rams scored 518 points to San Francisco&#8217;s 437 and the 49ers recorded only 20 sacks all season. Ultimately the live win probability sits in the Signal block on this page.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-sfla-2\"><strong class=\"schema-faq-question\">What time is 49ers vs Rams in the UK?<\/strong> <p class=\"schema-faq-answer\">1.35am BST on Friday 11 September, which is 8:35 PM ET on the Thursday.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-sfla-3\"><strong class=\"schema-faq-question\">How can I watch 49ers vs Rams in the UK?<\/strong> <p class=\"schema-faq-answer\">Sky Sports has the broadcast and NFL Game Pass on DAZN carries it as well. Kickoff is 1.35am BST on Friday 11 September.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-sfla-4\"><strong class=\"schema-faq-question\">Who starts at quarterback for the Rams?<\/strong> <p class=\"schema-faq-answer\">Matthew Stafford, who threw for 4,707 yards and 46 touchdowns in 2025. Meanwhile Brock Purdy starts for San Francisco.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-sfla-5\"><strong class=\"schema-faq-question\">What is the score prediction for 49ers vs Rams?<\/strong> <p class=\"schema-faq-answer\">Rams 27-23. Los Angeles brought the higher-scoring offence and San Francisco&#8217;s 20 sacks were the fewest of any side in this round.<\/p><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>18+ | Please gamble responsibly | BeGambleAware.org | Signal probabilities approximate at time of writing and subject to change<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our 49ers vs Rams prediction leans to Los Angeles in a 1.35am BST start for anyone watching from Britain. Both sides open the 2026 NFL season here, a night after the league gets going in Seattle. Squawka Signal&#8217;s live read on this game, including where the value sits, is in the block just below. Both&#8230;<\/p>\n","protected":false},"author":394,"featured_media":1487028,"menu_order":0,"template":"","meta":{"_acf_changed":false,"_yoast_wpseo_focuskw":"49ers vs rams prediction","_yoast_wpseo_title":"49ers vs Rams Prediction & Tips: Week 1 | Squawka","_yoast_wpseo_metadesc":"Our 49ers vs Rams prediction, tips and odds for Thursday night at SoFi Stadium. Two 12-5 sides, 1.35am BST kickoff. 18+.","footnotes":""},"tags":[27538,26951,27545],"class_list":["post-1487029","nfl-news","type-nfl-news","status-publish","has-post-thumbnail","hentry","tag-los-angeles-rams","tag-nfl","tag-san-francisco-49ers"],"acf":{"external_featured_image_url":"","hide_featured_image_pattern":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>49ers vs Rams Prediction &amp; Tips: Week 1 | Squawka<\/title>\n<meta name=\"description\" content=\"Our 49ers vs Rams prediction, tips and odds for Thursday night at SoFi Stadium. Two 12-5 sides, 1.35am BST kickoff. 18+.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"49ers vs Rams Prediction &amp; Tips: Week 1\" \/>\n<meta property=\"og:description\" content=\"Our 49ers vs Rams prediction, tips and odds for Thursday night at SoFi Stadium. Two 12-5 sides, 1.35am BST kickoff. 18+.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/\" \/>\n<meta property=\"og:site_name\" content=\"Squawka | EN\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SquawkaFootballNews\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-08T10:14:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/media.squawka.com\/images\/2026\/09\/08101216\/49ers-vs-rams-prediction-picks-odds-week-1-uk.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2400\" \/>\n\t<meta property=\"og:image:height\" content=\"1260\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@squawka\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/\"},\"author\":{\"name\":\"Tom Dutton\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/#\\\/schema\\\/person\\\/dc09c06d049425cf5fe14094195dd949\"},\"headline\":\"49ers vs Rams Prediction &#038; Tips: Week 1\",\"datePublished\":\"2026-09-08T09:12:17+00:00\",\"dateModified\":\"2026-09-08T10:14:55+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/\"},\"wordCount\":802,\"image\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/media.squawka.com\\\/images\\\/2026\\\/09\\\/08101216\\\/49ers-vs-rams-prediction-picks-odds-week-1-uk.jpg\",\"keywords\":[\"Los Angeles Rams\",\"NFL\",\"San Francisco 49ers\"],\"inLanguage\":\"en-GB\"},{\"@type\":[\"WebPage\",\"FAQPage\"],\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/\",\"url\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/\",\"name\":\"49ers vs Rams Prediction & Tips: Week 1 | Squawka\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/media.squawka.com\\\/images\\\/2026\\\/09\\\/08101216\\\/49ers-vs-rams-prediction-picks-odds-week-1-uk.jpg\",\"datePublished\":\"2026-09-08T09:12:17+00:00\",\"dateModified\":\"2026-09-08T10:14:55+00:00\",\"description\":\"Our 49ers vs Rams prediction, tips and odds for Thursday night at SoFi Stadium. Two 12-5 sides, 1.35am BST kickoff. 18+.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#breadcrumb\"},\"mainEntity\":[{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#faq-sfla-1\"},{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#faq-sfla-2\"},{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#faq-sfla-3\"},{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#faq-sfla-4\"},{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#faq-sfla-5\"}],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#primaryimage\",\"url\":\"https:\\\/\\\/media.squawka.com\\\/images\\\/2026\\\/09\\\/08101216\\\/49ers-vs-rams-prediction-picks-odds-week-1-uk.jpg\",\"contentUrl\":\"https:\\\/\\\/media.squawka.com\\\/images\\\/2026\\\/09\\\/08101216\\\/49ers-vs-rams-prediction-picks-odds-week-1-uk.jpg\",\"width\":2400,\"height\":1260,\"caption\":\"49ers vs Rams prediction, tips and odds for Week 1 of the 2026 NFL season, live on Sky Sports\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Squawka\",\"item\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"NFL News\",\"item\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"49ers vs Rams Prediction &#038; Tips: Week 1\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/\",\"name\":\"Squawka | EN\",\"description\":\"Football News, Stats, and More...\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/#\\\/schema\\\/person\\\/dc09c06d049425cf5fe14094195dd949\",\"name\":\"Tom Dutton\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d4acd11a360b4e606b52b1c1a739360b26e29c0b699f930bf67c9e9acbb4d53f?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d4acd11a360b4e606b52b1c1a739360b26e29c0b699f930bf67c9e9acbb4d53f?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d4acd11a360b4e606b52b1c1a739360b26e29c0b699f930bf67c9e9acbb4d53f?s=96&d=mm&r=g\",\"caption\":\"Tom Dutton\"},\"description\":\"Tom Dutton oversees Squawka\u2019s content strategy and works to make data-driven soccer analysis clear and accessible for fans. He has over a decade of experience in sports media, with articles published across several UK sports outlets. Previously published at: The Evening Standard , The Independent\",\"url\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/author\\\/tomdutton\\\/\"},{\"@type\":\"Question\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#faq-sfla-1\",\"position\":1,\"url\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#faq-sfla-1\",\"name\":\"Who is favourite to win, the 49ers or the Rams?\",\"answerCount\":1,\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Los Angeles. Both finished 12-5, but the Rams scored 518 points to San Francisco's 437 and the 49ers recorded only 20 sacks all season. Ultimately the live win probability sits in the Signal block on this page.\",\"inLanguage\":\"en-GB\"},\"inLanguage\":\"en-GB\"},{\"@type\":\"Question\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#faq-sfla-2\",\"position\":2,\"url\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#faq-sfla-2\",\"name\":\"What time is 49ers vs Rams in the UK?\",\"answerCount\":1,\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"1.35am BST on Friday 11 September, which is 8:35 PM ET on the Thursday.\",\"inLanguage\":\"en-GB\"},\"inLanguage\":\"en-GB\"},{\"@type\":\"Question\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#faq-sfla-3\",\"position\":3,\"url\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#faq-sfla-3\",\"name\":\"How can I watch 49ers vs Rams in the UK?\",\"answerCount\":1,\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Sky Sports has the broadcast and NFL Game Pass on DAZN carries it as well. Kickoff is 1.35am BST on Friday 11 September.\",\"inLanguage\":\"en-GB\"},\"inLanguage\":\"en-GB\"},{\"@type\":\"Question\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#faq-sfla-4\",\"position\":4,\"url\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#faq-sfla-4\",\"name\":\"Who starts at quarterback for the Rams?\",\"answerCount\":1,\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Matthew Stafford, who threw for 4,707 yards and 46 touchdowns in 2025. Meanwhile Brock Purdy starts for San Francisco.\",\"inLanguage\":\"en-GB\"},\"inLanguage\":\"en-GB\"},{\"@type\":\"Question\",\"@id\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#faq-sfla-5\",\"position\":5,\"url\":\"https:\\\/\\\/www.squawka.com\\\/en\\\/nfl\\\/nfl-news\\\/49ers-vs-rams-prediction-picks-odds-week-1\\\/#faq-sfla-5\",\"name\":\"What is the score prediction for 49ers vs Rams?\",\"answerCount\":1,\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Rams 27-23. Los Angeles brought the higher-scoring offence and San Francisco's 20 sacks were the fewest of any side in this round.\",\"inLanguage\":\"en-GB\"},\"inLanguage\":\"en-GB\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"49ers vs Rams Prediction & Tips: Week 1 | Squawka","description":"Our 49ers vs Rams prediction, tips and odds for Thursday night at SoFi Stadium. Two 12-5 sides, 1.35am BST kickoff. 18+.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/","og_locale":"en_GB","og_type":"article","og_title":"49ers vs Rams Prediction & Tips: Week 1","og_description":"Our 49ers vs Rams prediction, tips and odds for Thursday night at SoFi Stadium. Two 12-5 sides, 1.35am BST kickoff. 18+.","og_url":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/","og_site_name":"Squawka | EN","article_publisher":"https:\/\/www.facebook.com\/SquawkaFootballNews\/","article_modified_time":"2026-09-08T10:14:55+00:00","og_image":[{"width":2400,"height":1260,"url":"https:\/\/media.squawka.com\/images\/2026\/09\/08101216\/49ers-vs-rams-prediction-picks-odds-week-1-uk.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_site":"@squawka","twitter_misc":{"Estimated reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#article","isPartOf":{"@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/"},"author":{"name":"Tom Dutton","@id":"https:\/\/www.squawka.com\/en\/#\/schema\/person\/dc09c06d049425cf5fe14094195dd949"},"headline":"49ers vs Rams Prediction &#038; Tips: Week 1","datePublished":"2026-09-08T09:12:17+00:00","dateModified":"2026-09-08T10:14:55+00:00","mainEntityOfPage":{"@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/"},"wordCount":802,"image":{"@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#primaryimage"},"thumbnailUrl":"https:\/\/media.squawka.com\/images\/2026\/09\/08101216\/49ers-vs-rams-prediction-picks-odds-week-1-uk.jpg","keywords":["Los Angeles Rams","NFL","San Francisco 49ers"],"inLanguage":"en-GB"},{"@type":["WebPage","FAQPage"],"@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/","url":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/","name":"49ers vs Rams Prediction & Tips: Week 1 | Squawka","isPartOf":{"@id":"https:\/\/www.squawka.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#primaryimage"},"image":{"@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#primaryimage"},"thumbnailUrl":"https:\/\/media.squawka.com\/images\/2026\/09\/08101216\/49ers-vs-rams-prediction-picks-odds-week-1-uk.jpg","datePublished":"2026-09-08T09:12:17+00:00","dateModified":"2026-09-08T10:14:55+00:00","description":"Our 49ers vs Rams prediction, tips and odds for Thursday night at SoFi Stadium. Two 12-5 sides, 1.35am BST kickoff. 18+.","breadcrumb":{"@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#breadcrumb"},"mainEntity":[{"@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#faq-sfla-1"},{"@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#faq-sfla-2"},{"@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#faq-sfla-3"},{"@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#faq-sfla-4"},{"@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#faq-sfla-5"}],"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#primaryimage","url":"https:\/\/media.squawka.com\/images\/2026\/09\/08101216\/49ers-vs-rams-prediction-picks-odds-week-1-uk.jpg","contentUrl":"https:\/\/media.squawka.com\/images\/2026\/09\/08101216\/49ers-vs-rams-prediction-picks-odds-week-1-uk.jpg","width":2400,"height":1260,"caption":"49ers vs Rams prediction, tips and odds for Week 1 of the 2026 NFL season, live on Sky Sports"},{"@type":"BreadcrumbList","@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Squawka","item":"https:\/\/www.squawka.com\/en\/"},{"@type":"ListItem","position":2,"name":"NFL News","item":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/"},{"@type":"ListItem","position":3,"name":"49ers vs Rams Prediction &#038; Tips: Week 1"}]},{"@type":"WebSite","@id":"https:\/\/www.squawka.com\/en\/#website","url":"https:\/\/www.squawka.com\/en\/","name":"Squawka | EN","description":"Football News, Stats, and More...","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.squawka.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Person","@id":"https:\/\/www.squawka.com\/en\/#\/schema\/person\/dc09c06d049425cf5fe14094195dd949","name":"Tom Dutton","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/d4acd11a360b4e606b52b1c1a739360b26e29c0b699f930bf67c9e9acbb4d53f?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/d4acd11a360b4e606b52b1c1a739360b26e29c0b699f930bf67c9e9acbb4d53f?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/d4acd11a360b4e606b52b1c1a739360b26e29c0b699f930bf67c9e9acbb4d53f?s=96&d=mm&r=g","caption":"Tom Dutton"},"description":"Tom Dutton oversees Squawka\u2019s content strategy and works to make data-driven soccer analysis clear and accessible for fans. He has over a decade of experience in sports media, with articles published across several UK sports outlets. Previously published at: The Evening Standard , The Independent","url":"https:\/\/www.squawka.com\/en\/author\/tomdutton\/"},{"@type":"Question","@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#faq-sfla-1","position":1,"url":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#faq-sfla-1","name":"Who is favourite to win, the 49ers or the Rams?","answerCount":1,"acceptedAnswer":{"@type":"Answer","text":"Los Angeles. Both finished 12-5, but the Rams scored 518 points to San Francisco's 437 and the 49ers recorded only 20 sacks all season. Ultimately the live win probability sits in the Signal block on this page.","inLanguage":"en-GB"},"inLanguage":"en-GB"},{"@type":"Question","@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#faq-sfla-2","position":2,"url":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#faq-sfla-2","name":"What time is 49ers vs Rams in the UK?","answerCount":1,"acceptedAnswer":{"@type":"Answer","text":"1.35am BST on Friday 11 September, which is 8:35 PM ET on the Thursday.","inLanguage":"en-GB"},"inLanguage":"en-GB"},{"@type":"Question","@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#faq-sfla-3","position":3,"url":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#faq-sfla-3","name":"How can I watch 49ers vs Rams in the UK?","answerCount":1,"acceptedAnswer":{"@type":"Answer","text":"Sky Sports has the broadcast and NFL Game Pass on DAZN carries it as well. Kickoff is 1.35am BST on Friday 11 September.","inLanguage":"en-GB"},"inLanguage":"en-GB"},{"@type":"Question","@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#faq-sfla-4","position":4,"url":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#faq-sfla-4","name":"Who starts at quarterback for the Rams?","answerCount":1,"acceptedAnswer":{"@type":"Answer","text":"Matthew Stafford, who threw for 4,707 yards and 46 touchdowns in 2025. Meanwhile Brock Purdy starts for San Francisco.","inLanguage":"en-GB"},"inLanguage":"en-GB"},{"@type":"Question","@id":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#faq-sfla-5","position":5,"url":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/49ers-vs-rams-prediction-picks-odds-week-1\/#faq-sfla-5","name":"What is the score prediction for 49ers vs Rams?","answerCount":1,"acceptedAnswer":{"@type":"Answer","text":"Rams 27-23. Los Angeles brought the higher-scoring offence and San Francisco's 20 sacks were the fewest of any side in this round.","inLanguage":"en-GB"},"inLanguage":"en-GB"}]}},"yoast_title":"49ers vs Rams Prediction & Tips: Week 1 | Squawka","yoast_description":"Our 49ers vs Rams prediction, tips and odds for Thursday night at SoFi Stadium. Two 12-5 sides, 1.35am BST kickoff. 18+.","yoast_keyword":"49ers vs rams prediction","_links":{"self":[{"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/nfl-news\/1487029","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/nfl-news"}],"about":[{"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/types\/nfl-news"}],"author":[{"embeddable":true,"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/users\/394"}],"version-history":[{"count":2,"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/nfl-news\/1487029\/revisions"}],"predecessor-version":[{"id":1487101,"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/nfl-news\/1487029\/revisions\/1487101"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/media\/1487028"}],"wp:attachment":[{"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/media?parent=1487029"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.squawka.com\/en\/wp-json\/wp\/v2\/tags?post=1487029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}