{"id":1410532,"date":"2025-11-13T13:53:01","date_gmt":"2025-11-13T13:53:01","guid":{"rendered":"https:\/\/www.squawka.com\/en\/?post_type=nfl-news&#038;p=1410532"},"modified":"2025-11-13T14:01:24","modified_gmt":"2025-11-13T14:01:24","slug":"san-francisco-49ers-vs-arizona-cardinals-betting-tips-predictions-nov-16-2025-expert-nfl-analysis","status":"publish","type":"nfl-news","link":"https:\/\/www.squawka.com\/en\/nfl\/nfl-news\/san-francisco-49ers-vs-arizona-cardinals-betting-tips-predictions-nov-16-2025-expert-nfl-analysis\/","title":{"rendered":"San Francisco 49ers vs Arizona Cardinals Betting Tips &#038; Predictions (Nov 16, 2025) | Expert NFL Analysis"},"content":{"rendered":"<div class=\"author-credentials\">\n<p><strong>Analysis by Andy Francis, NFL Betting Analyst<\/strong><br \/>? 12+ years NFL betting analysis\u00a0<br \/>? Specialising in statistical modelling and data-driven predictions<\/p>\n<\/div>\n<h2 id=\"quick-picks\">? Quick Picks: San Francisco 49ers vs Arizona Cardinals<\/h2>\n<ul>\n<li><strong>Best Bet:<\/strong> Back the San Francisco 49ers Moneyline (projected edge on season metrics, superior turnover margin)<\/li>\n<li><strong>Total Lean:<\/strong> Under 45.5 \u2013 Teams profile to strong defensive play and below-league average pace<\/li>\n<li><strong>Player Prop:<\/strong> Emari Demercado Over 49.5 rushing yards \u2013 Faces a defence allowing explosive carries, consistently efficient (4.6 YPC)<\/li>\n<li><strong>Key Stat:<\/strong> 49ers 10 takeaway margin leads NFC, limiting red-zone scores to 23%<\/li>\n<li><strong>Kickoff:<\/strong> Sunday, 16 November, 21:05 GMT | ? FOX (Sky Sports NFL)<\/li>\n<\/ul>\n<p class=\"rg\">18+ | BeGambleAware.org | Please bet responsibly.<\/p>\n<h2 id=\"game-info\">When and Where is San Francisco 49ers vs Arizona Cardinals?<\/h2>\n<ul>\n<li><strong>Matchup:<\/strong> <a href=\"https:\/\/squawka.com\/en\/nfl\/teams\/san-francisco-49ers\/\" target=\"_blank\" rel=\"noopener\">San Francisco 49ers (6-4)<\/a> at <a href=\"https:\/\/squawka.com\/en\/nfl\/teams\/arizona-cardinals\/\" target=\"_blank\" rel=\"noopener\">Arizona Cardinals (3-6)<\/a><\/li>\n<li><strong>Date &amp; Time:<\/strong> Sunday, 16 November 2025 \u2013 21:05 GMT<\/li>\n<li><strong>Venue:<\/strong> State Farm Stadium, Glendale, AZ<\/li>\n<li><strong>Broadcast:<\/strong> FOX (UK: Sky Sports NFL)<\/li>\n<li><strong>Weather:<\/strong> Controlled climate (retractable dome) \u2013 no impact on totals<\/li>\n<\/ul>\n<h2 id=\"predictions\">San Francisco 49ers vs Arizona Cardinals: Expert Betting Tips &amp; Predictions<\/h2>\n<h3>Moneyline Analysis<\/h3>\n<p>Backing the 49ers on the road profiles as value\u2014San Francisco ranks top three in NFC West for turnover margin (+10) and third-down conversion rate (68.8%). The Cardinals&#8217; inconsistent red-zone performance (22% TD rate) weakens their upset credentials. Recent form gives the 49ers further edge, bolstered by a balanced attack and an opportunistic defence.<\/p>\n<h3>Totals Prediction (Over\/Under)<\/h3>\n<p>This contest projects as a defensive grind. Both teams average just 22\u201323 points per game and play below league-average pace, with extended time of possession (30:00 each). Head-to-head trends (31, 59, 62.5 total points last three seasons, but only 31 in 2025&#8217;s first meeting) point to the Under if defensive metrics hold and recent injuries persist for key skill players.<\/p>\n<h3>Player Prop Recommendations<\/h3>\n<ul>\n<li>Emari Demercado (ARI) Over 49.5 Rushing Yards: 291 yards at 4.6 YPC in 2025, strong usage profile.<\/li>\n<li>Christian McCaffrey (SF) Anytime TD: Leads team in red-zone usage, faces ARI run defence giving up 6.5 YPP.<\/li>\n<li>Ricky Pearsall (SF) Over 3.5 Receptions: Profiles to see increased share versus a depleted Arizona secondary.<\/li>\n<\/ul>\n\n    <div class=\"sq-toplist\">\n        <div class=\"sq-toplist__items\">\n\t\t\t    <div\n            class=\"sq-toplist__item\"\n            data-entity-id=\"1381364\"\n            data-offer-id=\"1381449\"\n    >\n\t\t        <div class=\"sq-toplist__item-container\">\n            <div class=\"sq-toplist__offer\">\n\t\t\t\t\t\t\t\t\t<a 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Profiles as a close, lower-scoring divisional clash.<\/span>\n                    <\/label>\n\t\t\t\t\t                        <div class=\"sq-accordion__animation\">\n                            <div class=\"sq-accordion__animation-wrapper\">\n                                <div class=\"sq-accordion__frame\">\n                                    <div class=\"sq-top-tip__content sq-accordion__content\">\n                                        <blockquote class=\"sq-top-tip__quote\">\n                                            <q>Matchup: San Francisco 49ers @ Arizona Cardinals<\/q>\n                                        <\/blockquote>\n                                    <\/div>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n\t\t\t\t\t\t\t\t\t\t<div class=\"sq-top-tip__buttons\" style=\"padding-top: 10px;\">\n\t\t\t\t\t\t<span class=\"sq-top-tip__buttons-text\">Best Odds<\/span>\n\t\t\t\t\t\t<span class=\"sq-btn sq-btn--image\">\n\t\t\t\t\t\t\t<span class=\"sq-btn__icon\" style=\"background: #0e4c40\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"60\" src=\"https:\/\/media.squawka.com\/images\/2025\/04\/29203621\/paddypower.svg\" class=\"attachment-medium size-medium\" sizes=\"auto, (max-width: 300px) 100vw, 300px\">\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<span class=\"sq-btn__odd\">6\/4<\/span>\n\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<a href=\"https:\/\/www.paddypower.com\/?AFF_ID=1381364&#038;OT=NFL49ERS\" target=\"_blank\" data-placement=\"nfl-betting-tips\" data-rating=\"8.5\" data-position=\"1\" data-placement-details=\"cta\" class=\"sq-btn sq-btn--secondary\">\n\t\t\t\t\t\t\tPlace bet\t\t\t\t\t\t<\/a>\t\t\t\t            \n\t\t\t\t\t<\/div>\n                <\/div>\n\t\t\t        <\/div>\n\t\t\n\t\t<div class=\"sq-top-tip__tc\">\n\t\t\t<div class=\"sq-top-tip__tc-text\">\n\t\t\t\t18+ | T&amp;C\u2019s Apply | begambleaware.org\n\t\t\t<\/div>\n\t\t<\/div>\n    <\/div>\n\n\n<h2 id=\"bet-builder\">Bet Builder Ideas for San Francisco 49ers vs Arizona Cardinals<\/h2>\n<h3>Conservative Bet Builder<\/h3>\n<ul>\n<li>49ers to win + Under 48.5 + Emari Demercado Over 39.5 rush yards<\/li>\n<\/ul>\n<p><strong>Rationale:<\/strong> San Francisco&#8217;s defensive consistency, controlled game scripts, and Cardinals&#8217; heavy run reliance shape this low-variance combination.<\/p>\n<h3>Value Bet Builder<\/h3>\n<ul>\n<li>49ers to score first + Under 23.5 Cardinals points + Christian McCaffrey Anytime TD<\/li>\n<\/ul>\n<p><strong>Rationale:<\/strong> Arizona&#8217;s first-half scoring struggles and heavy McCaffrey involvement in red zone.<\/p>\n<h3>High-Odds Bet Builder<\/h3>\n<ul>\n<li>49ers -7.5 handicap + Both teams to score under 20 in first half + 49ers Over 2.5 sacks<\/li>\n<\/ul>\n<p><strong>Rationale:<\/strong> 49ers&#8217; top NFC sack efficiency and Cardinals&#8217; patchwork O-line foster plus odds; both teams ranked top 12 for first half unders in recent splits.<\/p>\n<h2 id=\"key-stats-trends\">What are the Key Stats for San Francisco 49ers vs Arizona Cardinals?<\/h2>\n<figure class=\"wp-block-table is-style-stripes\">\n<table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th data-align=\"center\">Metric<\/th>\n<th class=\"has-text-align-center\" data-align=\"center\">Arizona Cardinals (Home)<\/th>\n<th class=\"has-text-align-center\" data-align=\"center\">San Francisco 49ers (Away)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td class=\"has-text-align-center\" data-align=\"center\">Pts\/Game<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">22.0<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">23.0<\/td>\n<\/tr>\n<tr>\n<td class=\"has-text-align-center\" data-align=\"center\">Yds\/Play<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">6.5<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">7.6<\/td>\n<\/tr>\n<tr>\n<td class=\"has-text-align-center\" data-align=\"center\">3rd Down %<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">64.5%<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">68.8%<\/td>\n<\/tr>\n<tr>\n<td class=\"has-text-align-center\" data-align=\"center\">Red Zone TD %<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">22.0%<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">23.0%<\/td>\n<\/tr>\n<tr>\n<td class=\"has-text-align-center\" data-align=\"center\">Turnover Diff<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">+4<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">+10<\/td>\n<\/tr>\n<tr>\n<td class=\"has-text-align-center\" data-align=\"center\">Pressure Rate<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">34.0%<\/td>\n<td class=\"has-text-align-center\" data-align=\"center\">18.0%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<h3>Matchup-Specific Trends<\/h3>\n<ul>\n<li>Arizona is 1-4 at home in 2025, averaging 19.2 PPG at State Farm Stadium<\/li>\n<li>San Francisco is 3-2 on the road, allowing just 20.1 PPG in away games<\/li>\n<li>Previous matchup (2025): 49ers edged Cardinals 16-15, total points well under market line<\/li>\n<li>Both defensive units top 10 in third down disruption and overall PPG allowed last 3<\/li>\n<\/ul>\n<h2 id=\"head-to-head\">San Francisco 49ers vs Arizona Cardinals Head-to-Head Record<\/h2>\n<p>The last five meetings between these NFC West rivals have produced a mix of shootouts (twice over 60 points in 2023) and low-scoring nailbiters (31 points this September). The 49ers narrowly took the most recent clash, holding a 3-2 mark in the last five with an average margin of 8.7 points.<\/p>\n<ul>\n<li>21 Sep 2025: 49ers 16, Cardinals 15 (Levi&#8217;s Stadium)<\/li>\n<li>05 Jan 2025: Cardinals 47, 49ers 24 (State Farm Stadium)<\/li>\n<li>06 Oct 2024: 49ers 23, Cardinals 24 (Levi&#8217;s Stadium)<\/li>\n<li>17 Dec 2023: Cardinals 29, 49ers 45 (State Farm Stadium)<\/li>\n<li>01 Oct 2023: 49ers 35, Cardinals 16 (Levi&#8217;s Stadium)<\/li>\n<\/ul>\n<p><strong>Betting Insight:<\/strong> Clashes are often closer in Arizona, with unders cashing in three of the last five. Expect a tight divisional script favouring points bettors who back the under.<\/p>\n<h2 id=\"why-watch\">Why This Game Matters for Bettors<\/h2>\n<ul>\n<li><strong>Division implications:<\/strong> Critical for the 49ers keeping pressure on the playoff race and tiebreakers. Cards are playing spoiler at home.<\/li>\n<li><strong>Offensive matchup:<\/strong> Run-first Cardinals against a San Francisco side boasting the conference&#8217;s top yards per play figure.<\/li>\n<li><strong>Defensive edge:<\/strong> 49ers have a +10 turnover margin and disruptive third-down defence; Cardinals bring pressure but risk chunk plays.<\/li>\n<li><strong>Star power:<\/strong> McCaffrey, Demercado, Pearsall all capable of explosive plays if defences over-commit.<\/li>\n<li><strong>Situational factors:<\/strong> Recent injuries for both sides, and clock control trending to first-half unders.<\/li>\n<\/ul>\n<h2 id=\"key-matchups\">What are the Key Matchups in San Francisco 49ers vs Arizona Cardinals?<\/h2>\n<h3>49ers O-Line vs Cardinals Pass Rush<\/h3>\n<p>San Francisco&#8217;s offensive line allowed just 18% pressure this season (lowest in NFC West), but Arizona creates pressure on 34% of dropbacks. If the 49ers\u2019 protection holds, Purdy and the passing game gain a sizeable edge.<\/p>\n<h3>Demercado (ARI) vs 49ers Run Defence<\/h3>\n<p>Demercado averages 8.96 YPC behind a heavy interior run scheme. San Francisco\u2019s line has been vulnerable to power runners in recent away games, projecting Demercado for a strong workload and efficient total yardage.<\/p>\n<h3>McCaffrey (SF) vs Cardinals Linebackers<\/h3>\n<p>Christian McCaffrey\u2019s involvement both as a rusher and receiver is pivotal. Arizona\u2019s linebackers allow above-average reception rates to RBs, making McCaffrey an every-down X-factor for the prop market and DFS.<\/p>\n<h2 id=\"player-watch\">Which Players Will Impact San Francisco 49ers vs Arizona Cardinals?<\/h2>\n<h3>Arizona Cardinals Players to Watch<\/h3>\n<p><strong>Emari Demercado (RB)<\/strong><br \/><strong>Role:<\/strong> Workhorse back. <br \/><strong>Recent Form:<\/strong> 233 yards on 26 attempts for the season<br \/><strong>Matchup Note:<\/strong> Faces a SF team conceding chunk runs in recent away splits.<br \/><strong>Betting Angle:<\/strong> Profiles to top 50+ yards if Cardinals can stay close early.<\/p>\n<p><strong>Michael Wilson (WR)<\/strong><br \/><strong>Role:<\/strong> Primary perimeter threat.<br \/><strong>Recent Form:<\/strong> 231 yards, 22 receptions on the season<br \/><strong>Matchup Note:<\/strong> If active, will test the 49ers&#8217; outside corners.<br \/><strong>Betting Angle:<\/strong> Pivotal for any Cardinals\u2019 upsets or over bets.<\/p>\n<p><strong>Trey McBride (TE)<\/strong><br \/><strong>Role:<\/strong> Short-area target and red zone option.<br \/><strong>Recent Form:<\/strong> 603 yards, 6 TDs on the season<br \/><strong>Matchup Note:<\/strong> 49ers allowed middle-of-field yards to TEs in recent games.<br \/><strong>Betting Angle:<\/strong> Deserves a look if the injury report favours him.<\/p>\n<h3>San Francisco 49ers Players to Watch<\/h3>\n<p><strong>Christian McCaffrey (RB)<\/strong><br \/><strong>Role:<\/strong> Three-down back and red zone driver.<br \/><strong>Recent Form:<\/strong> Team\u2019s leading rusher and scorer.<br \/><strong>Matchup Note:<\/strong> Faces LB group surrendering elite RB fantasy outputs.<br \/><strong>Betting Angle:<\/strong> Popular anytime TD play, double-digit carries expected.<\/p>\n<p><strong>Brock Purdy (QB)<\/strong><br \/><strong>Role:<\/strong> Efficient passer, commands best YPP split in division.<br \/><strong>Recent Form:<\/strong> Managed two-consecutive road wins, limiting turnovers.<br \/><strong>Matchup Note:<\/strong> Has time behind strong O-line, should avoid costly mistakes.<br \/><strong>Betting Angle:<\/strong> Lean completions over if Arizona dials up blitz pressure.<\/p>\n<p><strong>Ricky Pearsall (WR)<\/strong><br \/><strong>Role:<\/strong> Top downfield option.<br \/><strong>Recent Form:<\/strong> 327 yards on 20 receptions on the season<br \/><strong>Matchup Note:<\/strong> Arizona secondary undermanned.<br \/><strong>Betting Angle:<\/strong> Overs on props (catches\/yards) have value.<\/p>\n<h2 id=\"injuries-transactions\">San Francisco 49ers vs Arizona Cardinals Injury Report &amp; Team News<\/h2>\n<h3>Arizona Cardinals Injury Updates<\/h3>\n<ul>\n<li><strong>Marvin Harrison Jr. (WR):<\/strong> Illness \u2013 Questionable; monitor inactives.<\/li>\n<li><strong>Mack Wilson Sr. (LB):<\/strong> Ribs \u2013 DNP this week; defence thins if inactive.<\/li>\n<li><strong>Dadrion Taylor-Demerson (SAF):<\/strong> Ankle \u2013 DNP, secondary depth concern.<\/li>\n<li><strong>Zay Jones (WR):<\/strong> Placed on IR (10 Nov).<\/li>\n<li><strong>Michael Carter (RB):<\/strong> Signed to active roster (8 Nov).<\/li>\n<\/ul>\n<h3>San Francisco 49ers Injury Updates<\/h3>\n<ul>\n<li><strong>Brock Purdy (QB):<\/strong> Toe (limited); expected to start barring setback.<\/li>\n<li><strong>Christian McCaffrey (RB):<\/strong> Rest day (DNP, not injury-related).<\/li>\n<li><strong>Ricky Pearsall (WR):<\/strong> Knee, limited in practice.<\/li>\n<li><strong>Ben Bartch (OL):<\/strong> Activated from IR (8 Nov).<\/li>\n<\/ul>\n<p><strong>Betting Impact:<\/strong> Monitor Marvin Harrison Jr. and SF backfield; key for props and total market moves.<\/p>\n<p><em>Monitor official inactives list 90 minutes before kickoff for final injury updates.<\/em><\/p>\n<h2 id=\"x-factors\">X-Factors &amp; Betting Angles for San Francisco 49ers vs Arizona Cardinals<\/h2>\n<ul>\n<li><strong>Home\/Away Splits:<\/strong> 49ers&#8217; +10 turnover margin on the road dwarfs Cardinals&#8217; +2 at home.<\/li>\n<li><strong>Pass Rush vs Offensive Line:<\/strong> Arizona creates league-high 34% pressure but 49ers surrender just 18%.<\/li>\n<li><strong>Pace of Play:<\/strong> Both sides average 30:00 time of possession \u2013 grinds clock, drags scoring.<\/li>\n<li><strong>Special Teams:<\/strong> Minimal field goal data this season, but both have reliable kick units.<\/li>\n<li><strong>Situational Performance:<\/strong> Both top 12 in third-down conversions, but red zone efficiency is strikingly low (22\u201323%).<\/li>\n<\/ul>\n<h2 id=\"key-players-trends\">Who are the Statistical Leaders for San Francisco 49ers and Arizona Cardinals?<\/h2>\n<h3>Arizona Cardinals Statistical Leaders<\/h3>\n<ul>\n<li><strong>Passing:<\/strong> Jacoby Brissett (QB): 1118 yards, 8 TDs<\/li>\n<li><strong>Rushing:<\/strong> Emari Demercado (RB): 233 yards, 26 attempts<\/li>\n<li><strong>Receiving:<\/strong> Trey McBridge (TE): 603 yards, 6 TDs, 61 receptions<\/li>\n<li><strong>Defense:<\/strong> 34 sacks, 4 INTs (team total, leading pressure rate in matchup).<\/li>\n<\/ul>\n<h3>San Francisco 49ers Statistical Leaders<\/h3>\n<ul>\n<li><strong>Passing:<\/strong> Brock Purdy (QB): 586 yards, 4 TDs\u00a0<\/li>\n<li><strong>Rushing:<\/strong> Christian McCaffrey (RB): 626 yards, 4 TDs, 3.48 YPC<\/li>\n<li><strong>Receiving:<\/strong> Ricky Pearsall (WR): 327 yards, 20 receptions<\/li>\n<li><strong>Defense:<\/strong> 18 sacks, 10 INT (forcing turnovers at double Arizona&#8217;s rate).<\/li>\n<\/ul>\n<h2 id=\"standings-context\">Division &amp; Playoff Implications<\/h2>\n<h3>Arizona Cardinals<\/h3>\n<p>Currently bottom of NFC West (3-6), the Cards can only play spoiler to playoff hopefuls. Mathematically alive but major outsiders.<\/p>\n<h3>San Francisco 49ers<\/h3>\n<p>Third in NFC West (6-4), still in the thick of a wild card race, needing wins against division rivals to keep pace. Every intra-division win crucial for tiebreakers and playoff seeding.<\/p>\n<p><strong>Betting Context:<\/strong> Expect maximum urgency from the 49ers, especially if it&#8217;s tight late and margin-of-victory tiebreakers linger for postseason spots.<\/p>\n<h2 id=\"bottom-line\">San Francisco 49ers vs Arizona Cardinals: Final Betting Verdict<\/h2>\n<p>The data points to the 49ers holding several reliable edges\u2014turnover margin, third-down rate, and greater stability at key offensive positions. Arizona\u2019s inability to convert red-zone opportunities should cap their ceiling, especially if Harrison Jr. is limited. This profiles as a game that leans under, with San Francisco projecting as the stronger, more consistent betting side on both moneyline and against the spread for bettors seeking value.<\/p>\n<p class=\"rg\"><strong>18+ | BeGambleAware.org | Please bet responsibly.<\/strong><\/p>\n<h2 id=\"faqs\">Frequently Asked Questions: San Francisco 49ers vs Arizona Cardinals<\/h2>\n<h3>What time is San Francisco 49ers vs Arizona Cardinals kickoff?<\/h3>\n<p>Sunday 16 November 2025, 21:05 GMT. Live on FOX and Sky Sports NFL.<\/p>\n<h3>What are the best bets for San Francisco 49ers vs Arizona Cardinals?<\/h3>\n<p>The best betting recommendations are 49ers Moneyline, Under 45.5 total points, and overs on Trey Benson\u2019s rushing yards. Lean value on San Francisco props and defensive unders.<\/p>\n<h3>Where can I watch San Francisco 49ers vs Arizona Cardinals?<\/h3>\n<p>FOX (US), Sky Sports NFL (UK), NFL Game Pass for global streaming.<\/p>\n<h3>What is the injury report for San Francisco 49ers vs Arizona Cardinals?<\/h3>\n<p>Key question marks include Marvin Harrison Jr. (illness), Mack Wilson Sr. (ribs), and Purdy (toe\/limited) but expected to start. Zay Jones remains on IR for Arizona.<\/p>\n<section id=\"video\">\n<h2>San Francisco 49ers vs Arizona Cardinals Preview Video<\/h2>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=OrmK-jetNCo\" target=\"_blank\" rel=\"noopener\">Marvin Harrison Jr. out Week 11, Irving seen at practice | Fantasy Football Happy Hour | NFL on NBC<\/a><\/p>\n<\/section>\n\n\n<script type=\"application\/ld+json\">\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@graph\": [\n    {\n      \"@type\": \"NewsArticle\",\n      \"@id\": \"#article\",\n      \"headline\": \"San Francisco 49ers vs Arizona Cardinals Betting Tips & Predictions (Nov 16, 2025) | Expert NFL Analysis\",\n      \"articleSection\": [\"NFL\", \"Preview\", \"NFL Betting Tips\", \"Predictions\", \"Bet Builder\"],\n      \"inLanguage\": \"en-GB\",\n      \"datePublished\": \"2025-11-13\",\n      \"dateModified\": \"2025-11-13\",\n      \"wordCount\": 1498,\n      \"author\": {\n        \"@type\": \"Person\",\n        \"name\": \"Andy Francis\",\n        \"url\": \"https:\/\/www.squawka.com\/en\/author\/andrewfrancis\/\",\n        \"jobTitle\": \"NFL Betting Analyst\",\n        \"description\": \"NFL betting expert specialising in data-driven predictions and statistical analysis\"\n      },\n      \"publisher\": {\n        \"@type\": \"Organization\",\n        \"name\": \"Squawka.com\",\n        \"logo\": {\n          \"@type\": \"ImageObject\",\n          \"url\": \"https:\/\/www.squawka.com\/en\/\"\n        }\n      },\n      \"about\": {\"@id\": \"#event\"},\n      \"mainEntityOfPage\": \"https:\/\/www.squawka.com\/en\/nfl\/previews\/san-francisco-49ers-arizona-cardinals-2025-11-16\/\",\n      \"keywords\": [\"NFL\", \"San Francisco 49ers\", \"Arizona Cardinals\", \"NFL Preview\", \"NFL Betting Tips\", \"NFL Predictions\", \"Bet Builder\"],\n      \"genre\": \"Sports\",\n      \"description\": \"San Francisco 49ers vs Arizona Cardinals betting tips, key stats, injury news, and expert NFL predictions for 16 November 2025.\"\n    },\n    {\n      \"@type\": \"SportsEvent\",\n      \"@id\": \"#event\",\n      \"name\": \"San Francisco 49ers at Arizona Cardinals\",\n      \"sport\": \"American Football\",\n      \"startDate\": \"2025-11-16T21:05:00+00:00\",\n      \"location\": {\n        \"@type\": \"StadiumOrArena\",\n        \"name\": \"State Farm Stadium\"\n      },\n      \"homeTeam\": {\"@id\": \"#homeTeam\"},\n      \"awayTeam\": {\"@id\": \"#awayTeam\"},\n      \"eventAttendanceMode\": \"https:\/\/schema.org\/OfflineEventAttendanceMode\",\n      \"description\": \"NFL Week 11 matchup and betting preview.\"\n    },\n    {\n      \"@type\": \"SportsTeam\",\n      \"@id\": \"#homeTeam\",\n      \"name\": \"Arizona Cardinals\",\n      \"sport\": \"American Football\"\n    },\n    {\n      \"@type\": \"SportsTeam\",\n      \"@id\": \"#awayTeam\",\n      \"name\": \"San Francisco 49ers\",\n      \"sport\": \"American Football\"\n    },\n    {\n      \"@type\": \"FAQPage\",\n      \"@id\": \"#faq\",\n      \"mainEntity\": [\n        {\n          \"@type\": \"Question\",\n          \"name\": \"What time is San Francisco 49ers vs Arizona Cardinals kickoff?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Sunday 16 November, 21:05 GMT on FOX and Sky Sports NFL.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"What are the best bets for San Francisco 49ers vs Arizona Cardinals?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Moneyline San Francisco, Under 45.5 points, and Trey Benson rush props based on Season 2025 statistical edge.\"}\n        }\n      ]\n    },\n    {\n      \"@type\": \"BreadcrumbList\",\n      \"@id\": \"#breadcrumbs\",\n      \"itemListElement\": [\n        {\"@type\": \"ListItem\", \"position\": 1, \"name\": \"Home\", \"item\": \"https:\/\/www.squawka.com\/en\/\"},\n        {\"@type\": \"ListItem\", \"position\": 2, \"name\": \"NFL\", \"item\": \"https:\/\/www.squawka.com\/en\/nfl\/\"},\n        {\"@type\": \"ListItem\", \"position\": 3, \"name\": \"Previews\", \"item\": \"https:\/\/www.squawka.com\/en\/nfl\/previews\/\"},\n        {\"@type\": \"ListItem\", \"position\": 4, \"name\": \"San Francisco 49ers @ Arizona Cardinals\"}\n      ]\n    }\n  ]\n}\n<\/script>\n","protected":false},"excerpt":{"rendered":"<p>Analysis by Andy Francis, NFL Betting Analyst? 12+ years NFL betting analysis\u00a0? Specialising in statistical modelling and data-driven predictions ? Quick Picks: San Francisco 49ers vs Arizona Cardinals Best Bet: Back the San Francisco 49ers Moneyline (projected edge on season metrics, superior turnover margin) Total Lean: Under 45.5 \u2013 Teams profile to strong defensive play&#8230;<\/p>\n","protected":false},"author":427,"featured_media":1410533,"menu_order":0,"template":"","meta":{"_acf_changed":false,"_yoast_wpseo_focuskw":"san francisco 49ers arizona cardinals betting tips, san francisco 49ers arizona cardinals predictions, NFL betting offers","_yoast_wpseo_title":"San Francisco 49ers vs Arizona Cardinals Betting Tips (Nov 16, 2025) | Squawka NFL","_yoast_wpseo_metadesc":"Expert San Francisco 49ers vs Arizona Cardinals betting tips with statistical analysis, injury reports, and data-driven predictions. Best bets, player props & bet builders for 16 Nov 2025.","footnotes":""},"tags":[27546,27545],"class_list":["post-1410532","nfl-news","type-nfl-news","status-publish","has-post-thumbnail","hentry","tag-arizona-cardinals","tag-san-francisco-49ers"],"acf":{"external_featured_image_url":"","hide_featured_image_pattern":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>San Francisco 49ers vs Arizona Cardinals Betting Tips (Nov 16, 2025) | Squawka NFL<\/title>\n<meta name=\"description\" content=\"Expert San Francisco 49ers vs Arizona Cardinals betting tips with statistical analysis, injury reports, and data-driven predictions. 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