Italy look to make it two Rugby World Cup wins from two when they face Uruguay at Stade de Nice on Wednesday (4.45pm BST).
Gli Azzurri were commanding 52-8 winners over Namibia in their opening Pool B match, though Uruguay gave a positive account of themselves in their credible 27-12 defeat by host nation France.
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With matches against New Zealand and France, Italy know they must get a result here to stand any chance of progressing to the knockout stages for the first time.
Meanwhile, Uruguay have never won two matches at a World Cup. But with Namibia to come, Los Teros realistically need to win this game to have a genuine chance to achieve that.
Italy have made four changes to the side they put out against Namibia last week, with Lorenzo Pani, Alessandro Garbisi, Niccolo Cannone and Marco Riccioni all coming in for their first starts at this World Cup.
Meanwhile, following their encouraging performance against the French, Esteban Meneses makes just two changes to the Uruguay starting XV as he introduces Gaston Mieres and German Kessler.
Italy XV: Ange Capuozzo; Lorenzo Pani, Juan Ignacio Brex, Paolo Garbisi, Montanna Ioane; Tommaso Allan, Alessandro Garbisi; Danilo Fischetti, Giacomo Nicotera, Marco Riccioni; Niccolo Cannone, Federico Ruzza; Sebastian Negri, Michele Lamaro (captain), Lorenzo Cannone.
Replacements: Luca Bigi, Federico Zani, Pietro Ceccarelli, Dino Lamb, Manuel Zuliani, Giovanni Pettinelli, Alessandro Fusco, Paolo Odogwu.
Uruguay XV: Baltazar Amaya; Gaston Mieres, Tomas Inciarte, Andres Vilaseca (captain), Nicolas Freitas; Felipe Etcheverry, Santiago Arata; Mateo Sanguinetti, German Kessler, Ignacio Peculo; Felipe Aliaga, Manuel Leindekar; Manuel Ardao, Santiago Civetta, Manuel Diana.
Replacements: Guillermo Pujadas, Facundo Gattas, Diego Arbelo, Ignacio Dotti, Carlos Deus, Agustin Ormaechea, Felipe Berchesi, Bautista Basso.
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