The two Premier League sides are aiming to avoid falling at the first hurdle of the competition when they clash at the London Stadium.
Both arrive off the back of victories that have ended a difficult run of form.
Indeed, West Ham have recorded back-to-back wins after a streak of five matches without one.
It is now 42 years since the Hammers claimed major silverware, and David Moyes will be targeting a strong run in the FA Cup.
Meanwhile, Leeds ended a run of three successive defeats with their 3-1 success over Burnley last time out.
Having struggled to build on their solid return to the top-flight last term, Marcelo Bielsa’s side will hope this competition can provide a welcome distraction from their domestic struggles.
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West Ham United vs Leeds United: Match Stats
We can expect goals with both sides struggling defensively of late; failing to keep a clean sheet in each of their last five matches across all competitions.
Meanwhile, Leeds are aiming to avoid a fifth consecutive exit in the third round of the FA Cup, in which they have lost nine of their last 11 away games.
West Ham United vs Leeds United: Squawka Says
Scoreline prediction: West Ham United 2-1 Leeds United
September 25, 2021: Leeds 1-2 West Ham – Premier League
March 8, 2021: West Ham 2-0 Leeds – Premier League
December 11, 2020: Leeds 1-2 West Ham – Premier League
March 17, 2012: Leeds 1-1 West Ham – Championship
August 21, 2011: West Ham 2-2 Leeds – Championship
West Ham have scored exactly two goals in each of the last three meetings between the sides since Leeds’ return to the Premier League.