David Moyes’ side have collected maximum points from their opening two games in Group H.
West Ham began with a 2-0 victory over Dinamo Zagreb at the London Stadium, before overcoming Rapid Vienna by the same scoreline.
Declan Rice found the net on both occasions, with the England international’s manager recently describing him as one of the best young midfielders in Europe.
The Hammers are enjoying an impressive streak of form as they approach the midway point in the group stages; winning four of their last five matches.
They have kept a clean sheet in three of those; something that will offer little encouragement to a Genk side looking to end a run of three straight defeats.
Although, it is worth noting that the Belgian side have only been beaten four times in their last 19 away games in the Europa League.
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West Ham United vs Genk: Match Stats
Under the lights at the London Stadium, Rice will look to find the net for the third European match running.
If he does so, the England midfielder would become only the third West Ham player to achieve the feat after Brian Dear (1965) and David Cross (1980).
The Hammers will certainly fancy their chances of hitting the ground running. After all, they have scored at least one first-half goal in each of their last 13 home games in all competitions.