The Blues are heavy favourites to continue their brilliant start to the season by claiming maximum points at Vicarage Road.
Sunday’s 1-1 draw with Manchester United marked only the second time in 11 matches that Thomas Tuchel’s side have not been victorious.
They have won on each of their last two visits to this ground, but have never beaten the Hornets away from home on three successive occasions.
Also, the Blues have failed to win their last five Premier League matches played on a Wednesday.
That will encourage Watford, who find themselves just four points above the relegation zone having lost six of their last nine games.
Claudio Ranieri faces his former club once again, and will be urging his players to draw inspiration from the resounding 4-1 victory over Manchester United in their last home game.
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Watford vs Chelsea: Match Stats
Chelsea arrive at Vicarage Road on the back of four straight away wins, with the Blues scoring 10 times without reply during that span.
As for Watford, they have now failed to keep a clean sheet in each of their last 23 Premier League matches.
Romelu Lukaku is due a goal. The striker returned from injury as a late substitute against Man United over the weekend, and has found the net three times at Vicarage Road in the English top-flight.
July 4, 2020: Chelsea 3-0 Watford – Premier League
November 2, 2019: Watford 1-2 Chelsea – Premier League
May 5, 2019: Chelsea 3-0 Watford – Premier League
December 26, 2018: Watford 1-2 Chelsea – Premier League
February 5, 2018: Watford 4-1 Chelsea – Premier League
Chelsea have won seven of the last eight meetings between the sides, including each of the four most recent encounters.