Spurs have won each of their last five meetings with the Saints on home soil, and are unbeaten in their five league games at the Tottenham Hotspur Stadium under Antonio Conte.
In fact, the Italian has overseen 20 victories from 21 home league games in charge of Tottenham and Internazionale.
Although, Spurs have demonstrated their vulnerabilities at the back in recent times; failing to keep a clean sheet in six matches across all competitions.
But if Tottenham have problems conceding, they are nothing compared to those of Southampton.
Since the start of 2021, Ralph Hassenhuttl’s side have let in 57 goals away from home in the Premier League – 18 more than any other team during that span.
The Saints have also dropped 20 points from winning positions this season, with only Newcastle United (21) surrendering more in the English top-flight.
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Tottenham Hotspur vs Southampton: Match Stats
This fixture is one that has been very much to the liking of Harry Kane over the years.
The England captain has been directly involved in 17 goals in his 12 Premier League starts against Southampton; scoring 11 and assisting six.
Meanwhile, he has netted five times in the three most recent encounters between the sides.
We can expect goals from the off here. Indeed, there has been a first-half goal in each of Tottenham’s last six home games – and each of Southampton’s last 11 away.
Tottenham Hotspur vs Southampton: Squawka Says
Scoreline prediction: Tottenham Hotspur 3-1 Southampton
December 28, 2021: Southampton 1-1 Tottenham Hotspur – Premier League
April 21, 2021: Tottenham Hotspur 2-1 Southampton – Premier League
September 20, 2020: Southampton 2-5 Tottenham Hotspur – Premier League
February 5, 2020: Tottenham Hotspur 3-2 Southampton – FA Cup
January 25, 2020: Southampton 1-1 Tottenham Hotspur – FA Cup
Both teams have scored in each of the last five meetings between the sides, with Tottenham prevailing on three occasions.