Inter are two points behind leaders AC Milan, but still have a game in hand on their city rivals.
The Nerazzurri will head to the summit with victory at Stadio Alberto Picco – although it may only be for a few hours if the Rossoneri overcome Genoa later on.
Nevertheless, Simone Inzaghi’s side appear to be hitting form at the right time in their bid to retain the Scudetto.
Indeed, they head to Liguria on a six-match unbeaten streak and if they keep winning, the title will be theirs.
Although, their next task will not be straightforward. Spezia are 15th in Serie A, but have kept three clean sheets in four games.
Another here would see them record three on the bounce in the Italian top-flight for the first time.
And Thiago Motta would love to get one over on one of his former sides, with whom he won Serie A and the Champions League during his playing career.
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Spezia vs Inter Milan: Match Stats
Inter have recorded six clean sheets in their last eight matches across all competitions.
The Nerazzurri will be confident of extending that solid streak against relegation-threatened Spezia.
The visitors are also likely to carry a great threat from set-pieces. Indeed, no side has earned more corners in Serie A this term (197).