Brendan Rodgers has overseen a tricky start to Group C for the Foxes.
After surrendering a 2-0 lead at home to Napoli on matchday one, Leicester were beaten 1-0 away at Legia Warsaw last time out in the competition.
Rodgers’ side put four goals past Manchester United in the Premier League on Saturday, but have generally struggled to find the net on the continent.
Indeed, they have drawn a blank in three of their last four Europa League matches, and won just once in their last seven.
Nevertheless, victory here would see the reigning FA Cup winners leapfrog Spartak, who have collected three points from their opening two games.
However, they have lost each of their last three at home in Europe.
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Spartak Moscow vs Leicester City: Match Stats
Once again, Leicester’s charge will more than likely be led by the in-form Jamie Vardy.
The evergreen striker heads to Russia having found the net five times in as many appearances for the Foxes.
Meanwhile, Spartak are seeking a first continental victory against English opposition in nine attempts.
Indeed, you must go back to a 4-1 rout of Arsenal in November 2000 for their last such win.
Spartak Moscow vs Leicester City: Squawka Says
Scoreline prediction: Spartak Moscow 1-1 Leicester City