Four points clear at the top of the table, Manchester City remain very much in the driving seat.
But Pep Guardiola’s side handed Liverpool a glimmer of hope after they were held to a 2-2 draw by West Ham United on Sunday.
Regardless of what the Reds do, the title will still be City’s if they beat Aston Villa next weekend.
All Liverpool can do is win their final two matches and hope for a favour from former skipper Steven Gerrard.
Jurgen Klopp’s side completed part two of a potential quadruple last weekend following victory over Chelsea in the FA Cup final.
And they will be confident of building on that momentum by taking all three points on the South Coast.
It is worth noting that they have won seven of their eight midweek Premier League matches this term.
Southampton are not expected to put up too much resistance; after all, they have won just once in their last 10 – keeping just a single clean sheet during that span.
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Southampton vs Liverpool match stats
The recent form book suggests Liverpool should be extremely confident heading to St Mary’s.
Indeed, Klopp’s side have won eight of their last nine Premier League meetings with Southampton, scoring at least two goals on each occasion.
But the Saints will be encouraged by their opponents’ recent frailties in defence.
In fact, the Reds have conceded the opening goal in each of their last two top-flight matches.
November 27, 2021: Liverpool 4-0 Southampton – Premier League
May 8, 2021: Liverpool 2-0 Southampton – Premier League
January 4, 2021: Southampton 1-0 Liverpool – Premier League
February 1, 2020: Liverpool 4-0 Southampton – Premier League
August 17, 2019: Southampton 1-2 Liverpool – Premier League
Despite their poor record in the fixture, Southampton are looking to record consecutive home Premier League victories over Liverpool for the first time since 2013.