Three points clear of second-placed Poland, the Three Lions have all but guaranteed their place in Qatar.
Indeed, they would only be denied by the Poles beating Hungary at Stadion Narodawy, as well as the most unlikely of upsets at Stadio Olimpico di Serravalle.
Following a relatively disappointing 1-1 draw with the Hungarians last month, Gareth Southgate’s side got back on track with a commanding 5-0 win over Albania on Friday.
The Euro 2020 finalists are now unbeaten over 90 minutes in each of their last 19 matches, winning 14 of those.
Extending that run to 20 would seal a seventh successive appearance at the finals.
They are heavily expected to get the job done without too many difficulties against the world’s lowest-ranked team.
San Marino have now lost each of their last 11 games, scoring just twice during that span.
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San Marino vs England: Match Stats
Following his perfect hat-trick against Albania, Harry Kane moved onto 44 international goals.
Moving level with the late, great Jimmy Greaves, only Wayne Rooney, Bobby Charlton and Gary Lineker have found the net more times for the Three Lions.
The Tottenham Hotspur striker also moved onto eight goals during this qualifying campaign; a tally only bettered by the Netherlands’ Memphis Depay.
He will certainly fancy adding to his total against San Marino; a side England have beaten on all seven previous occasions and scored 42 goals against along the way.
March 25, 2021: England 5-0 San Marino – World Cup Qualifier
September 5, 2015: San Marino 0-6 England – European Championship Qualifier
October 9, 2014: England 5-0 San Marino – European Championship Qualifier
March 22, 2013: San Marino 0-8 England – World Cup Qualifier
October 12, 2012: England 5-0 San Marino – World Cup Qualifier
England boast a perfect record against San Marino since their first meeting in February 1993, conceding just one goal in seven encounters.