Serbia lead the way on goal difference in Group A as they head to the Aviva Stadium.
Dragan Stojkovic’s men approach the midway point in the campaign with 10 points from their opening four games, level with former European champions Portugal.
As has been the case in recent years, Serbia’s charge will be led by Aleksandar Mitrovic.
The Fulham striker is the top scorer in qualifying with seven goals in four matches, including three braces.
As for the Republic, they have struggled to build any momentum since the appointment of Stephen Kenny, winning just one of his 15 games in charge.
Following a 1-1 draw with Azerbaijan last time out, the Green Army have just one point to their name and already have a mountain to climb if they are to stand any chance of qualifying for Qatar.
Republic of Ireland vs Serbia: Match Stats
Serbia have suffered just one defeat over 90 minutes in their last 13 matches.
Meanwhile, Ireland have scored just one goal in their five most recent outings on home soil.
Republic of Ireland vs Serbia: Squawka Says
Scoreline prediction: Republic of Ireland 0-3 Serbia
Republic of Ireland vs Serbia: Odds
Republic of Ireland vs Serbia: Head to Head
24 March 2021: Serbia 3-2 Republic of Ireland – World Cup Qualifier
5 September 2017: Republic of Ireland 0-1 Serbia – World Cup Qualifier
5 September 2016: Serbia 2-2 Republic of Ireland – World Cup Qualifier
5 March 2014: Republic of Ireland 1-2 Serbia – Friendly
15 August 2012: Serbia 0-0 Republic of Ireland – Friendly
Serbia are unbeaten in their six matches against the Republic since they began playing as an independent nation in 2006, winning three.