With Sevilla not in action until the following day, Carlo Ancelotti’s side can stretch their margin at the summit of the Spanish top-flight.
Los Blancos are unbeaten in their last eight home matches, keeping a clean sheet in each of the most recent four.
Not only that, but it is now almost a year since they last tasted defeat in La Liga at the Bernabeu.
Always a danger going forward with their envious list of attacking options, the 13-time European champions are now looking to score in a 20th successive league match.
Valencia have been on the losing side 90 times against Real in La Liga – more than any other side in the Spanish top-flight.
Los Che head coach Jose Bordalas has never masterminded a victory over Los Blancos in nine previous attempts, but his side do arrive in the capital having won each of their last five away games.
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Real Madrid vs Valencia: Match Stats
The form and history books point towards this match being a fruitful one for Karim Benzema.
Real Madrid’s number nine has scored in each of the last seven home matches when Los Blancos have found the net.
The France international has also been on target in his six most recent league appearances against Valencia.
September 19, 2021: Valencia 1-2 Real Madrid – La Liga
February 14, 2021: Real Madrid 2-0 Valencia – La Liga
November 8, 2020: Valencia 4-1 Real Madrid – La Liga
January 8, 2020: Valencia 1-3 Real Madrid – Spanish Super Cup
December 15, 2019: Valencia 1-1 Real Madrid – La Liga
Los Blancos have prevailed in three of the last four meetings between the sides, with Valencia’s last victory at the Bernabeu coming in March 2008.