Between them, the two sides have registered just a single point from their opening two games this season.
Steve Bruce’s Newcastle have suffered defeats against West Ham and Aston Villa, while they were also dumped out of the Carabao Cup on penalties by Burnley in midweek.
Although, the Magpies do boast an impressive record against Southampton at St James’ Park; winning each of the last four meetings and suffering just one defeat in 16.
After opening with defeat at Everton, the Saints earned a creditable draw against Manchester United before putting eight past Newport County on Wednesday.
However, they have lost each of their last six Premier League games away from St Mary’s.
Newcastle United vs Southampton: Match Stats
At least three goals have been scored in each of the last six meetings between the sides at St James’ Park.
You must go back to 2004-05 – the season they got relegated – for the last time Southampton lost seven successive away games in the Premier League.
Theo Walcott has been directly involved in 11 goals against Newcastle – five goals, six assists – more than he has managed against any other side in the English top flight.
Newcastle United vs Southampton: Squawka Says
Scoreline prediction: Newcastle United 2-1 Southampton
Newcastle United vs Southampton: Odds
Newcastle United vs Southampton: Head to Head
6 February 2021 – Newcastle United 3-2 Southampton
6 November 2020 – Southampton 2-0 Newcastle United
7 March 2020 – Southampton 0-1 Newcastle United
8 December 2019 – Newcastle United 2-1 Southampton
20 April 2019 – Newcastle United 3-1 Southampton
Newcastle have won each of the four most recent meetings at St James’ Park, where there have been at least three goals scored in the last six encounters.