Things are heating up nicely with three games remaining in the CONCACAF World Cup qualifying section.
With Canada four points clear at the top, just goal difference separates Mexico and the USA, who are third and second respectively.
Should other results go their way, victory for either side at the Azteca Stadium could secure their place in Qatar later this year.
Given what is at stake and the form of both teams, we can expect a tightly contested affair.
Mexico are unbeaten in four games after losing each of their previous three.
El Tri are notably strong on familiar territory, having lost just once in their last 18 home matches.
Meanwhile, the USA, who missed out on the 2018 World Cup, arrive off the back of three victories in four.
Desperate to return to the biggest stage, the Stars and Stripes have suffered just three defeats from a possible 22.
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Mexico vs USA: Match Stats
The USA won all three meetings between the nations in 2021.
Christian Pulisic played a key role in the American dominance during the streak.
Indeed, the Chelsea forward scored in two of his side’s three victories.
November 13, 2021: USA 2-0 Mexico – World Cup Qualifier
August 2, 2021: USA 1-0 Mexico – Gold Cup
June 7, 2021: USA 3-2 Mexico – Nations League
September 7, 2019: USA 0-3 Mexico – Friendly
July 8, 2019: Mexico 1-0 USA – Gold Cup
The two sides met three times in 2021, with the Americans prevailing on each occasion.