The top two in Group A do battle at the Etihad Stadium, with the winners booking their place in the last 16.
Although regardless of this result, both sides would progress should RB Leipzig beat Club Brugge on Wednesday.
Runners-up to Chelsea last season, City currently lead the way by a single point in their quest to go the extra step this term.
And they welcome the runaway Ligue 1 leaders having won each of their last three matches.
PSG are already a whopping 11 points clear at the summit of the French top-flight and look well on course to regain their domestic crown, after surrendering it to Lille last season.
Mauricio Pochettino’s side are unbeaten in seven matches – winning five – but it is worth noting that they have won just once in their last four away from home.
Manchester City vs Paris Saint-Germain: Betting Offer
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Manchester City vs Paris Saint-Germain: Match Stats
Riyad Mahrez has been City’s man of the moment so far in this season’s Champions League.
Indeed, the former Leicester winger has scored four goals in as many matches.
With the endless attacking quality at the disposal of both sides, we can surely expect goals here.
Manchester City vs Paris Saint-Germain: Squawka Says
Scoreline prediction: Manchester City 2-2 Paris Saint-Germain
8:00 pm Wednesday November 24
Manchester City 2-2 Paris Saint-GermainChampions League
Manchester City vs Paris Saint-Germain: Head to Head
September 28, 2021: Paris Saint-Germain 2-0 Manchester City – Champions League
May 4, 2021: Manchester City 2-0 Paris Saint-Germain – Champions League
April 28, 2021: Paris Saint-Germain 1-2 Manchester City – Champions League
April 12, 2016: Manchester City 1-0 Paris Saint-Germain – Champions League
April 6, 2016: Paris Saint-Germain 2-2 Manchester City – Champions League
City have won three of the last four meetings between the sides, including both legs of their Champions League semi-final last term.