Just a single goal separates the sides following Lucas Paqueta’s strike at Estadio do Dragao last week.
The omens appear good for Lyon, who have suffered just two defeats in 22 Europa League matches on home soil.
Also, Les Gones have only failed to progress once in six Europa League knockout ties after winning the first leg.
And this competition is certainly providing a welcome distraction for Peter Bosz’s side, who have lost two of their last three games in Ligue 1.
In fact, they have only kept one clean sheet from a possible five, which will encourage Porto as they look to turn things around.
The Dragons have won each of their last three European matches in France, and head there in impressive form.
Indeed, last week’s defeat represented the only reverse they have suffered in 19 games across all competitions.
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Lyon vs Porto: Match Stats
Moussa Dembele has certainly enjoyed playing at the Groupama Stadium in recent times.
Indeed, the striker has scored four goals in Lyon’s last five matches on home soil.
Since lifting the trophy under Andre Villas-Boas in 2010-11, Porto have failed to win any of their last eight away knockout games in the Europa League.
They have also conceded at least two goals on each occasion.