Leicester would boost their hopes of progressing to the knockout stages with victory at the King Power Stadium.
The Foxes are currently third in Group C – a point behind their opponents – but will climb into the top two with a win.
And with a difficult trip to Napoli coming up, Brendan Rodgers’ side will be desperate for a result here.
Although following Saturday’s 3-0 reverse by Premier League leaders Chelsea, Leicester are now without a win in four matches.
That will encourage Legia, who were 1-0 winners when the sides met in Poland in September.
However Marek Golebiewski’s side, who are 17th in the Ekstraklasa, have failed to kick on from that win; losing eight of their subsequent nine matches.
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Leicester City vs Legia Warsaw: Match Stats
Having netted four goals against Spartak Moscow last month, Patson Daka will be eager to build on his momentum in this competition.
Following that personal demolition in the Russian capital, his tally is only bettered by Lyon’s Karl Toko Ekambi.
Though heavy favourites, this will be far from straightforward for Leicester, who have won just once after 90 minutes in their last seven home matches.
Meanwhile, the Foxes are now without a clean sheet in 11 games.
Leicester City vs Legia Warsaw: Squawka Says
Scoreline prediction: Leicester City 3-1 Legia Warsaw