Top of Group G and four points clear of third-place Celtic, a point would be enough for Leverkusen to advance with a match to spare.
Gerardo Seoane’s side are unbeaten in this season’s competition, with 10 points from four games.
And Die Werkself were comprehensive 4-0 winners at Celtic Park in September.
Ange Postecoglou’s men have responded well to that setback by going unbeaten in nine matches, winning eight of those.
They also booked their place in the Scottish League Cup final on Saturday, with James Forrest’s strike sealing a narrow 1-0 victory over St. Johnstone.
With Real Betis facing pointless Ferencvaros in the other Group G clash, only a win in Germany would realistically do for the Hoops.
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Bayer Leverkusen vs Celtic: Match Stats
Leverkusen have only been beaten once in their last 14 Europa League matches on home soil.
Although, they have only mustered two clean sheets from their last eight games in all competitions, which will encourage a confident Celtic side.
The Hoops’ charge will be led by Kyogo Furuhashi, who has scored four goals in this year’s Europa League, and was on target in both of his side’s last two outings in the competition.