Real are six points clear at the summit of the Spanish top-flight, although that lead could be reduced should second-place Sevilla beat Barcelona on Tuesday.
Either way, Carlo Ancelotti’s side have the chance to establish breathing space heading into the festive break.
Los Blancos are looking to get back to winning ways following their goalless draw with Cadiz last weekend.
That result ended a run of 10 straight victories in all competitions.
As for Bilbao, they came from 2-1 down to beat Real Betis last time out; subsequently bringing an eight-game winless streak to an end.
And Marcelino will be eager to build on that by inspiring his side to only a second win over the 13-time European champions in 15 attempts.
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Athletic Bilbao vs Real Madrid: Match Stats
With 10 goals and four assists to his name in La Liga, it is fair to say that Vinicius Junior has come of age this season.
The Brazil international has specifically flourished on the road in recent weeks, scoring four times in Real’s last three games away from Santiago Bernabeu.
Los Blancos come into this game having kept five successive clean sheets, whereas Bilbao have only recorded two shutouts in their last 10 matches.
Athletic Bilbao vs Real Madrid: Squawka Says
Scoreline prediction: Athletic Bilbao 0-2 Real Madrid
December 1, 2021: Real Madrid 1-0 Athletic Bilbao – La Liga
May 16, 2021: Athletic Bilbao 0-1 Real Madrid – La Liga
January 14, 2021: Real Madrid 1-2 Athletic Bilbao – Supercopa de Espana
December 15, 2020: Real Madrid 3-1 Athletic Bilbao – La Liga
July 5, 2020: Athletic Bilbao 0-1 Real Madrid – La Liga
Real Madrid have won four of the last five meetings between the sides, while suffering just one defeat in 14.