Qualification for Qatar is secured, but Argentina will be eager to end their campaign on a high.
La Albiceleste are also protecting a 29-match unbeaten run stretching back to their defeat by Brazil at the 2019 Copa America.
Of course, Argentina avenged that loss against the Selecao at the delayed 2020 edition of the event last July, subsequently ending their 28-year wait for silverware.
They would love to follow that up with a genuine challenge for glory in Qatar later this year.
Lionel Scaloni will be urging his players to continue to build momentum against bottom side Venezuela.
Jose Pekerman, who oversaw Argentina at the 2006 World Cup, took over the reins in November; recording a win and loss in his opening two games.
The veteran coach must look to improve the fortunes of La Vinotinto, who have suffered nine defeats from a possible 11.
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Argentina vs Venezuela: Match Stats
Argentina’s impressive recent form has been built on a solid defensive foundation.
Scaloni’s side have kept seven clean sheets in their last eight matches.
Although, they have not boasted too much firepower at the other end of the field in recent times.
In fact, La Albiceleste have netted just five times in as many games.
September 3, 2021: Venezuela 1-3 Argentina – World Cup Qualifier
June 28, 2019: Venezuela 0-2 Argentina – Copa America
March 22, 2019: Argentina 1-3 Venezuela – Friendly
September 6, 2017: Argentina 1-1 Venezuela – World Cup Qualifier
September 7, 2016: Venezuela 2-2 Argentina – World Cup Qualifier
Venezuela have won just one of the last seven meetings between the sides, with Argentina prevailing four times during that span.