American Football

Tennessee Titans vs Indianapolis Colts: Predictions, betting trends and stats for Week 3

By Squawka NFL

Published: 15:24, 23 September 2021

The Tennessee Titans (1-1) host the Indianapolis Colts (0-2) on Sunday, September 26, 2021 in matchup between AFC South opponents at Nissan Stadium. Indianapolis is a 5.5-point underdog. The game’s point total is set at 48.

Titans vs Colts predictions

Computer predictions for Titans vs Colts
ATS Total Score prediction
Titans (-5.5) Over (48) Titans 32 Colts 20

Titans vs Colts head-to-head

Indianapolis holds a 3-2 advantage over Tennessee in the last five meetings between these two squads. The Titans and Colts are split 1-1 against the spread in those games while going over the point total both times. Indianapolis outscored Tennessee 129-127 in those five head-to-head matchups.

Titans vs Colts betting odds

Titans vs Colts Betting Information
Favorite Spread Favorite spread odds Underdog spread odds Total Over total odds Under total odds
Titans -5.5 -110 -110 48 -110 -110

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Titans vs Colts betting insights

Titans trends

  • Tennessee had seven wins in 16 games against the spread last year.
  • The Titans went 3-3 as 5.5-point favorites or more last season.
  • There were 12 Tennessee games (out of 16) that went over the total last season.
  • Last year, the Titans scored 8.1 more points per game (30.7) than the Colts allowed (22.6).
  • Tennessee was 7-5 against the spread and 10-2 overall last season when the team scored more than 22.6 points.
  • The Titans racked up 396.4 yards per game last year, 64.3 more yards than the 332.1 the Colts gave up per outing.
  • Tennessee was 6-6 against the spread and 10-2 overall when the team amassed more than 332.1 yards last season.

Colts trends

  • Indianapolis’ record against the spread last season was 8-8-0.
  • The Colts went unbeaten ATS (1-0) as underdogs of 5.5 points or greater last season.
  • In 16 Indianapolis games last year, nine of them went over the total.
  • The Colts scored 28.2 points per game last year, comparable to the 27.4 the Titans gave up.
  • When Indianapolis put up over 27.4 points last season, it was 6-2 against the spread and 8-0 overall.
  • The Colts racked up 20.2 fewer yards per game (378.1) than the Titans allowed (398.3) per contest last season.
  • When Indianapolis piled up more than 398.3 yards last year, the team was 4-3 against the spread and 5-2 overall.

Team stats

Compare 2020 season stats for Titans and Colts
Titans Stats Colts
239.1 Pass yards 261.6
287.1 Pass yards against 257.9
168.1 Rush yards 124.8
120.8 Rush yards against 90.5
+11 Turnover differential +10

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Player betting tips

Titans top players

  • Ryan Tannehill collected 3,819 passing yards (238.7 per game) with a 65.5% completion percentage last year, while throwing for 33 touchdowns with seven interceptions. He also led his team with 266 rushing yards on 43 carries and seven touchdowns.
  • A year ago Derrick Henry picked up 2,027 rushing yards (126.7 per game) and scored 17 touchdowns.
  • Last season A.J. Brown hauled in 70 passes for 1,075 yards (67.2 per game) with 11 touchdowns.
  • Julio Jones added 51 catches for 771 yards and three touchdowns.
  • Josh Reynolds caught 52 passes on 81 targets for 618 yards and two touchdowns, averaging 38.6 yards per game.
  • Bud Dupree showed out with an impressive stat line of 8.0 sacks, 11.0 TFL and 39 tackles last year.
  • Kevin Byard collected 143 tackles, 2.0 TFL, and one interception over the course of his last campaign.
  • Last season, Janoris Jenkins hauled in three interceptions and added 66 tackles, 2.0 TFL, and 12 passes defended.
Name Pass Yds Pass TDs Rush Yds Rush TDs Rec Yds Rec TDs
Ryan Tannehill 247.5 (-115) 16.5 (-123)
Derrick Henry 99.5 (-113) 11.5 (-113)
A.J. Brown 80.5 (-111)

Colts top players

  • Carson Wentz threw for 2,620 yards while completing 57.4% of his passes last season, with 16 touchdowns and 15 interceptions (163.8 yards per game). He also carried the ball 52 times for 276 yards and five TDs.
  • Jonathan Taylor ran for 1,169 yards on 232 attempts (73.1 yards per game) and scored 11 touchdowns a season ago. He also averaged 18.7 receiving yards per game, grabbing 36 passes for 299 yards and one TD.
  • Nyheim Hines amassed 380 rushing yards on 89 carries (23.8 yards per game), with three touchdowns on the ground. He also caught 63 passes for 482 yards (a team high) and four TDs.
  • Last year Zach Pascal hauled in 44 passes for 629 yards (39.3 per game) with five touchdowns.
  • Michael Pittman Jr. also tacked on 503 yards on 40 grabs and one touchdown. He was targeted 61 times, and averaged 38.7 receiving yards last year.
  • Last season DeForest Buckner totaled 9.5 sacks, 13.5 TFL and 79 tackles.
  • Darius Leonard racked up 178 tackles, 9.5 TFL, and 3.0 sacks over his 2020 campaign.
  • Kenny Moore II picked off four passes and tacked on 92 tackles, 4.0 TFL, 2.0 sacks, and 13 passes defended last season.


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