Los Angeles Rams vs San Francisco 49ers: Predictions, betting trends and stats for Week 10

By Squawka NFL

Published: 10:40, 11 November 2021

The Los Angeles Rams (7-2) visit the San Francisco 49ers (3-5) on Monday, November 15, 2021 in matchup between NFC West rivals at Levi’s Stadium. San Francisco is a 3.5-point underdog. The over/under is 48.5 for this game.

Rams vs 49ers predictions

Squawka predictions for Rams vs 49ers
ATS Total Score prediction
Rams (-3.5) Over (48.5) Rams 28 49ers 22

Last three results

Rams recent betting insights

  • Los Angeles has not covered the spread and is 2-1 overall in its last three games.
  • In its past three games, Los Angeles has hit the over once.
  • The Rams and their opponents have combined to score an average of 50.5 points over their last three games, 2.0 more than the 48.5 over/under in this matchup.

49ers recent betting insights

  • San Francisco has two wins against the spread, and is 2-1 overall, in its past three games.
  • In San Francisco’s past three contests, it has hit the over twice.
  • The 49ers total over the last three games is 6.0 points fewer than the 48.5 total given for this matchup.

Rams vs 49ers head-to-head

San Francisco has a 4-1 advantage over Los Angeles in the past five matchups between these two squads. The 49ers are 2-0 against the spread in those games against the Rams while the two teams haven’t managed to go over the point total. San Francisco outscored Los Angeles 133-122 in those five head-to-head matchups.

Rams vs 49ers betting odds

Rams vs 49ers betting information
Favorite Spread Favorite spread odds Underdog spread odds Total Over total odds Under total odds
Rams -3.5 -110 -110 48.5 -110 -110

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Rams vs 49ers betting insights

Rams trends

  • Los Angeles has put together a 4-6-0 record against the spread this season.
  • The Rams are 2-6 ATS when playing as at least 3.5-point favorites.
  • This season, Los Angeles’ games have hit the over five times out of 10 chances.
  • The Rams score 29.0 points per game, 3.7 more than the 49ers give up per matchup (25.3).
  • When Los Angeles scores more than 25.3 points, it is 4-4 against the spread and 7-0 overall.
  • The Rams rack up 399.3 yards per game, 61.2 more yards than the 338.1 the 49ers allow per matchup.
  • Los Angeles is 4-6 against the spread and 7-2 overall when the team piles up more than 338.1 yards.

49ers trends

  • San Francisco is 3-6-0 against the spread this season.
  • The 49ers are winless against the spread when they are 3.5-point underdogs or more (0-1).
  • This year, San Francisco’s games have hit the over five times out of nine chances.
  • The 49ers rack up 23.1 points per game, comparable to the 21.8 the Rams give up.
  • San Francisco is 2-2 against the spread and 2-1 overall in games when it puts up more than 21.8 points.
  • The 49ers rack up only 17.4 more yards per game (365.6) than the Rams allow per contest (348.2).
  • In games that San Francisco totals more than 348.2 yards, the team is 2-2 against the spread and 2-1 overall.

Team stats

Compare 2021 season stats for Rams and 49ers
Rams Stats 49ers
308.4 Pass yards 263.5
272.3 Pass yards against 223.0
103.0 Rush yards 113.1
99.6 Rush yards against 131.6
+5 Turnover differential -9

Player betting tips

Rams top players

  • Matthew Stafford has thrown for 2,771 yards while completing 68.2% of his passes (219-for-321), with 23 touchdowns and six interceptions (307.9 yards per game).
  • Stafford has had a passing touchdown in all nine games this year, with multiple passing TDs in seven of them.
  • Darrell Henderson has rushed for a team-best 562 yards (62.4 per game) and five touchdowns. He also has 144 receiving yards on 19 catches and two touchdowns.
  • Henderson has had a rushing touchdown in five games this year, but no games with multiple rushing TDs.
  • Cooper Kupp has 74 catches (103 targets) and paces his team with 1,019 receiving yards (113.2 ypg) and 10 touchdowns.
  • Kupp has scored a receiving touchdown in six of nine games this year, with multiple receiving TDs four times.

49ers top players

  • Jimmy Garoppolo has passed for 1,754 yards (139-of-213), with eight touchdowns and five interceptions (219.3 yards per game).
  • Elijah Mitchell has churned out a team-best 469 rushing yards (58.6 per game) and three touchdowns.
  • Trey Sermon has 135 yards on 31 carries (16.9 yards per game), with one rushing touchdown.
  • Deebo Samuel has 49 catches (81 targets) and paces his team with 882 receiving yards (110.3 per game) while scoring four touchdowns.
  • George Kittle’s stat line this year reveals 25 catches for 328 yards and one touchdown. He averages 65.6 receiving yards per game.
  • Brandon Aiyuk has caught 19 passes on 31 targets for 230 yards and two touchdowns, averaging 28.8 yards per game.


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