The Arizona Cardinals (4-0) are 5.5-point favorites as they look to prolong their four-game winning streak in a matchup against the San Francisco 49ers (2-2) on Sunday, October 10, 2021 at State Farm Stadium. The over/under is set at 49.5.
Cardinals vs 49ers predictions
|Cardinals (-5.5)||Over (49.5)||Cardinals 40 49ers 14|
Last 3 results
Cardinals Recent Betting Insights
- Arizona has covered the spread twice, and is 3-0 overall, over its last three contests.
- Arizona has hit the over twice in its past three contests.
- The Cardinals total over the last three games is 2.5 points more than the 49.5 over/under given for this matchup.
49ers recent betting insights
- Over its past three contests, San Francisco has one win against the spread, and is 1-2 overall.
- San Francisco has hit the over once in its past three games.
- The 49ers and their opponents have combined to score an average of 50.7 combined points over their last three games, 1.2 more than the 49.5 over/under in this matchup.
Cardinals vs 49ers head-to-head
San Francisco has an edge against Arizona over the past five matchups between these two squads, putting together a 3-2 record in those games. The Cardinals and 49ers have split those games 1-1 against the spread while not outpacing the total once. San Francisco outscored Arizona 119-105 in those five head-to-head matchups.
Cardinals vs 49ers betting odds
|Favorite||Spread||Favorite spread odds||Underdog spread odds||Total||Over total odds||Under total odds|
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Cardinals vs 49ers betting insights
- Arizona is 3-1-0 against the spread this season.
- The Cardinals have a perfect 1-0 ATS record when playing as at least 5.5-point favorites.
- Arizona’s games have gone over the total twice this season.
- This year, the Cardinals put up 9.5 more points per game (35.0) than the 49ers allow (25.5).
- When Arizona records more than 25.5 points, it is 3-1 against the spread and 4-0 overall.
- The Cardinals rack up 440.5 yards per game, 104.2 more yards than the 336.3 the 49ers allow per outing.
- Arizona is 3-1 against the spread and 4-0 overall when the team churns out over 336.3 yards.
- San Francisco has covered the spread once over four games with a set spread.
- Games involving San Francisco have hit the over twice this season.
- This year the 49ers put up 5.5 more points per game (26.8) than the Cardinals allow (21.3).
- San Francisco is 0-2 against the spread and 1-1 overall in games when it puts up more than 21.3 points.
- The 49ers average only 18.5 more yards per game (375.8) than the Cardinals allow (357.3).
- When San Francisco piles up over 357.3 yards, the team is 0-2 against the spread and 1-1 overall.
|240.3||Pass yards against||234.5|
|135.8||Rush yards against||118.0|
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Player betting tips
Cardinals top players
- Kyler Murray has passed for 1,273 yards (102-for-134), with nine touchdowns and four interceptions (318.3 YPG). He’s also run the ball 23 times for 109 yards and three touchdowns.
- Murray has thrown for a touchdown three times this season in four games played, including multiple TD passes three times.
- Chase Edmonds has run for a team-high 255 yards (63.8 YPG) and zero touchdowns. He also has 140 receiving yards on 20 catches .
- In four games this year, Edmonds has not yet rushed for a touchdown.
- A.J. Green has 15 receptions for a team-high 248 yards (62.0 per game) and two touchdowns.
- Green has had a receiving touchdown in two of four games this year, but he has not scored multiple receiving TDs in a game.
|Name||Pass Yds||Pass TDs||Rush Yds||Rush TDs||Rec Yds||Rec TDs|
|Kyler Murray||274.5 (-115)||–||34.5 (-113)||–||–||–|
|Chase Edmonds||–||–||40.5 (-120)||–||27.5 (-118)||–|
|A.J. Green||–||–||–||–||46.5 (-118)||–|
49ers top players
- Jimmy Garoppolo has thrown for 925 yards while completing 66.1% of his passes, with five touchdowns and two interceptions (231.3 yards per game).
- Elijah Mitchell has taken 36 carries for a team-leading 146 rushing yards (36.5 per game) while scoring one touchdown.
- So far this season Trey Sermon has run for 128 yards on 30 carries (32.0 yards per game), with one touchdown.
- Deebo Samuel has been targeted 42 times and has 28 catches, leading his team with 490 yards (122.5 per game) while hauling in three touchdowns.
- George Kittle has hauled in 19 catches for 227 yards (56.8 per game).
- Kyle Juszczyk is averaging 25.0 yards per game, with 11 catches for 100 yards and one touchdown.
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