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San Francisco 49ers vs Seattle Seahawks: Predictions, betting trends and stats for Week 4

By Squawka NFL

Published: 18:09, 1 October 2021 | Updated: 17:25, 6 October 2021

NFC West rivals meet when the San Francisco 49ers (2-1) host the Seattle Seahawks (1-2) on Sunday, October 3, 2021 at Levi’s Stadium. San Francisco is favoured by 3 points. The contest has an over/under of 51.5 points.

49ers vs Seahawks predictions

Computer predictions for 49ers vs Seahawks
ATS Total Score prediction
49ers (-3) Over (51.5) 49ers 28 Seahawks 24

49ers vs Seahawks head-to-head

Seattle holds an edge against San Francisco over the past five meetings between these two teams, putting together a 3-2 record in those games. The 49ers and Seahawks have an even 1-1 record against the spread in those games with the two squads going over the total both times. Seattle has had the scoring advantage in those five matchups, totaling 134 points while San Francisco put up 126.

49ers vs Seahawks betting odds

49ers vs Seahawks betting information
Favourite Spread Favourite spread odds Underdog spread odds Total Over total odds Under total odds
49ers -3 -105 -115 51.5 -110 -110

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49ers vs Seahawks betting insights

49ers trends

  • San Francisco has covered the spread one time this season (1-2-0).
  • The 49ers are winless against the spread when they have played as 3-point favourites or more (0-2).
  • San Francisco’s games have gone over the total twice this season.
  • The 49ers average 28.7 points per game, comparable to the 26.3 per matchup the Seahawks surrender.
  • When San Francisco records more than 26.3 points, it is 0-2 against the spread and 1-1 overall.
  • The 49ers average 91.6 fewer yards per game (348.7), than the Seahawks allow per contest (440.3).

Seahawks trends

  • Seattle has covered the spread one time this season (1-2-0).
  • Games involving Seattle have hit the over once this season.
  • This season the Seahawks rack up just 0.3 more points per game (25.0) than the 49ers allow (24.7).
  • Seattle is 1-1 against the spread and 1-1 overall in games when it scores more than 24.7 points.
  • The Seahawks average 389.0 yards per game, just 18.7 more than the 370.3 the 49ers allow.
  • In games that Seattle piles up more than 370.3 yards, the team is 1-2 against the spread and 1-2 overall.

Team stats

Compare 2021 season stats for 49ers and Seahawks
49ers Stats Seahawks
255.0 Pass yards 298.3
263.0 Pass yards against 307.0
105.0 Rush yards 107.7
122.3 Rush yards against 155.0
-3 Turnover differential +1

How to live stream 49ers vs Seahawks online

Bet365* are streaming a selection of games during the NFL 2021 season live for account holders. Those interested in watching NFL games live online can take advantage of this service by following the simple steps below.

  • Click on this link.
  • ‘Register’ and enter details.
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  • Navigate to the ‘Live’ option at the top of the homepage and select your desired event with a play symbol next to it.

*Geo restrictions apply, 18+ only, must have a funded account or placed a bet in the last 24 hours, BeGambleAware. All odds and offers within this article are accurate at the time of publication.

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Player betting tips

49ers top players

  • This season Jimmy Garoppolo has 760 passing yards (253.3 yards per game) while going 64-for-95 (67.4%) and tossing four touchdowns with one interception.
  • Garoppolo has had a passing touchdown in all three games this season, with multiple passing TDs in one of them.
  • Elijah Mitchell has churned out a team-high 146 rushing yards (48.7 per game) and one touchdown.
  • Mitchell has one rushing touchdown this season in three games played.
  • Deebo Samuel has 20 catches (on 30 targets) and leads the team with 334 receiving yards (111.3 per game) while hauling in one touchdown.
  • Samuel has one touchdown catch this season, in three games.

Seahawks top players

  • Russell Wilson has 895 passing yards (298.3 per game) with a 73.3% completion percentage (63-for-86), throwing for seven touchdowns. He also has 32 rushing yards on 11 carries.
  • Chris Carson has taken 41 attempts for a team-leading 202 rushing yards (67.3 per game) while scoring three touchdowns.
  • Alex Collins has rushed for 33 yards on three carries (11.0 yards per game).
  • Tyler Lockett has been targeted 20 times and has 16 catches, leading his team with 309 yards (103.0 per game) while scoring three touchdowns.
  • D.K. Metcalf has hauled in 16 catches for 220 yards (73.3 per game) and two touchdowns.
  • Freddie Swain has 105 receiving yards on six receptions (eight targets), with one touchdown.


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