American Football

San Francisco 49ers vs Detroit Lions: Predictions, betting trends and stats for Week 1

By Squawka NFL

Published: 9:44, 9 September 2021 | Updated: 15:22, 23 September 2021

The San Francisco 49ers (0-0) are one-touchdown favorites on Sunday, September 12, 2021 against the Detroit Lions (0-0). The total for this game has been set at 45.5 points.

49ers vs Lions predictions

Computer predictions for 49ers vs Lions
ATS Total Score prediction
Lions (+7) Over (45.5) 49ers 29 Lions 23

49ers vs Lions head-to-head

In the last five meetings between these two squads, San Francisco holds a 4-1 advantage over Detroit. San Francisco outscored Detroit 119-103 in those five head-to-head matchups.

49ers vs Lions betting odds

49ers vs Lions Betting Information
Favorite Spread Favorite spread odds Underdog spread odds Total Over total odds Under total odds
49ers -7 -115 -105 45.5 -110 -110

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49ers vs Lions betting insights

49ers trends

  • San Francisco’s record against the spread last season was 7-9-0.
  • The 49ers won once ATS (1-2) as a 7-point favorite or more last season.
  • In 16 San Francisco games last season, eight of them hit the over.
  • Last year, the 49ers put up 8.9 fewer points per game (23.5) than the Lions allowed (32.4).
  • San Francisco was 2-1 against the spread and 2-1 overall in games when it put up over 32.4 points last year.
  • The 49ers collected 49.7 fewer yards per game (370.1) than the Lions allowed per outing (419.8) last season.
  • San Francisco was 2-1 against the spread and 2-1 overall when the team picked up more than 419.8 yards last season.

Lions trends

  • Against the spread, Detroit was 7-9-0 last season.
  • The Lions had one win ATS (1-2) as underdogs of 7 points or more last season.
  • There were 10 Detroit games (out of 16) that hit the over last year.
  • The Lions racked up just 0.8 fewer points per game (23.6) than the 49ers surrendered (24.4) last year.
  • When Detroit scored over 24.4 points last year, it was 5-3 against the spread and 4-4 overall.
  • The Lions collected 35.8 more yards per game (350.2) than the 49ers gave up per contest (314.4) last year.
  • When Detroit amassed over 314.4 yards last season, the team was 6-5 against the spread and 5-6 overall.

Team stats

Compare 2020 season stats for 49ers and Lions
49ers Stats Lions
270 Pass yards 274.8
220.4 Pass yards against 297.1
118.1 Rush yards 93.7
106.4 Rush yards against 134.9
-11 Turnover differential -9

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Player betting tips

49ers top players

  • Jimmy Garoppolo threw for 1,096 yards last season (137 yards per game) while completing 67.1% of his passes (94-of-140), with seven touchdowns and five interceptions.
  • Raheem Mostert ran for 521 yards on 104 attempts (52.1 yards per game) while scoring two touchdowns a season ago. He also averaged 15.6 receiving yards per game, grabbing 16 passes for 156 yards and one touchdown.
  • JaMycal Hasty totaled 148 rushing yards on 39 carries (18.5 yards per game), with one touchdown on the ground, last year.
  • Last season, Brandon Aiyuk was targeted 96 times and had 60 catches for 748 yards (46.8 ypg) while scoring five touchdowns.
  • George Kittle also contributed with 634 yards on 48 grabs and two touchdowns. He was targeted 63 times and put up 63.4 receiving yards per game last year.
  • Deebo Samuel totaled 391 yards on 33 catches with one touchdown last year, averaging 30.1 yards per game on 44 targets.
  • Last season, Samson Ebukam put up 4.5 sacks, five TFL and 44 tackles.
  • In his most recent campaign, Fred Warner collected 170 tackles, six TFL, one sack, and two interceptions.

Lions top players

  • Last year Jared Goff put up 3,952 passing yards (247 yards per game) while going 370-for-552 (67% completion percentage) and throwing 20 touchdowns and 13 interceptions.
  • D’Andre Swift took 114 carries for 521 rushing yards a season ago (32.6 yards per game) while scoring eight touchdowns. He also caught 46 passes for 357 yards (22.3 receiving yards per game) with two touchdowns through the air.
  • Last season Jamaal Williams ran for 505 yards on 119 carries (31.6 ypg), with two rushing touchdowns.
  • Last season T.J. Hockenson was targeted 101 times and amassed 67 catches for 723 yards (45.2 ypg) and scored six touchdowns.
  • Quintez Cephus caught 20 passes on 35 targets for 349 yards and two touchdowns last year, averaging 21.8 yards per game.
  • Last season Romeo Okwara totaled 10 sacks, 14 TFL and 56 tackles.
  • Over the course of his 2020 campaign, Jamie Collins Sr. totaled 147 tackles, 6.5 TFL, one sack, and one interception.
  • Dean Marlowe intercepted two passes while adding 28 tackles, 2.5 TFL, 1.5 sacks, and three passes defended a season ago.

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