San Francisco 49ers vs Indianapolis Colts: Predictions, betting trends and stats for Week 7

By Squawka NFL

Published: 19:45, 21 October 2021

Oddsmakers give the San Francisco 49ers (2-3) a decent chance to halt their three-game losing streak, as they are favored by 4.5 points in a matchup with the Indianapolis Colts (2-4) on Sunday, October 24, 2021 at Levi’s Stadium. The total has been set at 44.5 points for this matchup.

49ers vs Colts predictions

Squawka predictions for 49ers vs Colts
ATS Total Score prediction
Colts (+4.5) Over (44.5) 49ers 24 Colts 22

Last three results

49ers recent betting insights

  • San Francisco has no wins against the spread and is 0-3 overall in its past three contests.
  • San Francisco has gone over the total once in its past three contests.
  • The 49ers and their opponents have combined to score an average of 50.5 points in their last three games, 6.0 more than the 44.5 over/under in this matchup.

Colts recent betting insights

  • In its last three games, Indianapolis has covered the spread each time, and is 2-1 overall.
  • In Indianapolis’ past three games, it has gone over the total twice.
  • The Colts and their opponents have combined to score an average of 44.5 combined points over their last three games, the same as the over/under posted in this matchup.

49ers vs Colts head-to-head

In the past five matchups between these two squads, Indianapolis holds the edge with a 4-1 record over San Francisco. Indianapolis has had the upper hand scoring in those five matchups, recording 120 points while San Francisco put up 87.

49ers vs Colts betting odds

49ers vs Colts betting information
Favourite Spread Favourite spread odds Underdog spread odds Total Over total odds Under total odds
49ers -4.5 -110 -110 44.5 -110 -110

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49ers vs Colts betting insights

49ers trends

  • San Francisco is 1-4-0 against the spread this season.
  • The 49ers are winless against the spread when they have played as 4.5-point favorites or more (0-1).
  • Games involving San Francisco have hit the over twice this season.
  • The 49ers rack up just 1.6 more points per game (23.4) than the Colts surrender (21.8).
  • San Francisco is 0-2 against the spread and 1-1 overall in games when it records more than 21.8 points.
  • The 49ers average only 1.7 more yards per game (368.2) than the Colts give up per contest (366.5).
  • San Francisco is 0-2 against the spread and 1-1 overall when the team picks up over 366.5 yards.

Colts trends

  • Indianapolis is 4-2-0 against the spread this season.
  • The Colts have an ATS record of 1-1 when playing as at least 4.5-point underdogs.
  • Indianapolis’ games have gone over the total three times this year.
  • The Colts rack up 23.2 points per game, comparable to the 23.8 the 49ers give up.
  • Indianapolis is 4-0 against the spread and 2-2 overall in games when it records more than 23.8 points.
  • The Colts rack up 367.5 yards per game, 37.7 more yards than the 329.8 the 49ers allow.
  • In games that Indianapolis totals over 329.8 yards, the team is 4-1 against the spread and 2-3 overall.

Team stats

Compare 2021 season stats for 49ers and Colts
49ers Stats Colts
255.8 Pass yards 261.7
235.4 Pass yards against 268.8
122.0 Rush yards 124.2
113.2 Rush yards against 111.0
-5 Turnover differential +7

Player betting tips

49ers top players

  • This season Jimmy Garoppolo has 925 passing yards (185.0 yards per game) while going 78-for-118 (66.1%) and connecting on five touchdowns with two interceptions.
  • Garoppolo has had a passing touchdown in four of five games this year, with multiple passing TDs in one of them.
  • Elijah Mitchell has churned out a team-leading 189 rushing yards (37.8 per game) and one touchdown.
  • Mitchell has one rushing touchdown this year in five games played.
  • Deebo Samuel has racked up 31 receptions for 548 yards, best on his team, and three touchdowns. He has been targeted 52 times, and averages 109.6 receiving yards per game.
  • In two of five games this season, Samuel has had a receiving touchdown (and one game with multiple receiving TDs).

Colts top players

  • Carson Wentz has passed for 1,545 yards (124-of-193), with nine touchdowns and one interception (257.5 yards per game). He’s also rushed 18 times for 74 yards.
  • Jonathan Taylor has taken 87 carries for a team-leading 472 rushing yards (78.7 per game) while scoring four touchdowns. He’s also caught 15 passes for a team-high 210 yards with one touchdown through the air.
  • Nyheim Hines has 101 yards on 26 carries (16.8 yards per game), with one rushing touchdown. He also has 15 catches for 133 yards.
  • This season Michael Pittman Jr. has 31 catches for a team-high 403 yards (67.2 per game) and one touchdown.
  • Zach Pascal has caught 18 passes on 29 targets for 204 yards and three touchdowns.


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