Arizona Cardinals vs San Francisco 49ers: Predictions, betting trends and stats for Week 9

By Squawka NFL

Published: 14:56, 4 November 2021

The San Francisco 49ers (3-4) are slight, 1-point underdogs in a home NFC West matchup with the Arizona Cardinals (7-1) on Sunday, November 7, 2021 at Levi’s Stadium. This matchup has an over/under of 45 points.

Cardinals vs 49ers predictions

Squawka predictions for Cardinals vs 49ers
ATS Total Score prediction
Cardinals (-1) Over (45) Cardinals 30 49ers 18

Last three results

Cardinals recent betting insights

  • Arizona has covered the spread twice, and is 2-1 overall, over its past three contests.
  • In Arizona’s past three contests, it has gone over the total once.
  • The Cardinals have averaged a total of 49.2 combined points over their last three games, 4.2 greater than this game’s over/under of 45.

49ers recent betting insights

  • San Francisco has covered the spread twice, and is 2-1 overall, over its past three games.
  • San Francisco has hit the over twice in its past three contests.
  • The 49ers and their opponents have combined to score an average of 42.3 combined points in their last three games, 2.7 less than the 45 over/under in this matchup.

Cardinals vs 49ers head-to-head

San Francisco holds a 3-2 advantage over Arizona in the past five matchups between these two squads. The Cardinals and 49ers have split those games 1-1 against the spread while failing to go over the total once. San Francisco totaled 119 points in those five matchups compared to Arizona’s 105.

Cardinals vs 49ers betting odds

Cardinals vs 49ers betting information
Favorite Spread Favorite spread odds Underdog spread odds Total Over total odds Under total odds
Cardinals -1 -105 -115 45 -110 -110

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Cardinals vs 49ers betting insights

Cardinals trends

  • Arizona has covered the spread six times over eight games with a set spread.
  • In games they have played as 1-point favorites or more, the Cardinals have an ATS record of 3-2.
  • Games involving Arizona have hit the over three times this season.
  • The Cardinals score 30.8 points per game, 6.4 more than the 49ers surrender per matchup (24.4).
  • When Arizona scores more than 24.4 points, it is 5-1 against the spread and 6-0 overall.
  • The Cardinals collect 393.6 yards per game, 69.6 more yards than the 324.0 the 49ers give up per matchup.
  • When Arizona amasses over 324.0 yards, the team is 5-2 against the spread and 6-1 overall.

49ers trends

  • San Francisco has covered the spread three times over eight games with a set spread.
  • The 49ers are winless against the spread when they are 1-point underdogs or more (0-1).
  • Games involving San Francisco have hit the over four times out of eight chances this season.
  • This season the 49ers score 6.7 more points per game (24.0) than the Cardinals surrender (17.3).
  • San Francisco is 2-4 against the spread and 2-3 overall in games when it scores more than 17.3 points.
  • The 49ers rack up 369.7 yards per game, 50.7 more yards than the 319.0 the Cardinals give up.
  • In games that San Francisco piles up over 319.0 yards, the team is 2-3 against the spread and 2-2 overall.

Team stats

Compare 2021 season stats for Cardinals and 49ers
Cardinals Stats 49ers
284.5 Pass yards 254.6
214.0 Pass yards against 214.6
128.8 Rush yards 123.7
120.1 Rush yards against 127.1
+5 Turnover differential -6

How to live stream Cardinals vs 49ers online

Bet365* are streaming a selection of games during the NFL 2021 season live for account holders. Those interested in watching NFL games live online can take advantage of this service by following the simple steps below.

  • Click on this link.
  • ‘Register’ and enter details.
  • Log in and fund your account.
  • Navigate to the ‘Live’ option at the top of the homepage and select your desired event with a play symbol next to it.

Player betting tips

Cardinals top players

  • Kyler Murray has 2,276 yards through the air (284.5 per game) and a 72.7% completion percentage (186-for-256), pitching 17 touchdown passes and seven interceptions. He also has 147 rushing yards on 49 carries (with three touchdowns).
  • Murray has had a passing touchdown in six of eight games this season, with multiple passing TDs in five of them.
  • Chase Edmonds has 75 attempts for a team-best 427 rushing yards (53.4 per game) and one touchdown. He also has 30 catches for 211 receiving yards (26.4 per game).
  • Edmonds has rushed for a touchdown once this season in eight games played.
  • DeAndre Hopkins has hauled in 35 receptions for 486 yards, best on his team, and seven touchdowns. He has been targeted 49 times, and averages 60.8 receiving yards per game.
  • Hopkins has had a touchdown catch five times this season, out of eight games played, but had multiple TD receptions only twice.
Select player props for the Arizona Cardinals
Name Pass Yds Pass TDs Rush Yds Rush TDs Rec Yds Rec TDs
Kyler Murray 279.5 (-113) 2.5 (+107) 32.5 (-109)
Chase Edmonds 49.5 (-117) 28.5 (-107)
DeAndre Hopkins 74.5 (-111)

49ers top players

  • This season Jimmy Garoppolo has put up 1,428 passing yards (204.0 per game) while going 111-for-173 (64.2%) and throwing for six touchdowns with four interceptions.
  • Elijah Mitchell has 81 carries for a team-high 433 rushing yards (61.9 per game) and three touchdowns.
  • So far this year Trey Sermon has rushed for 135 yards on 31 carries (19.3 yards per game), with one touchdown.
  • Deebo Samuel has grabbed 44 passes for a team best 819 yards and four touchdowns. He has been targeted 72 times, and averages 117.0 yards per game.
  • Mohamed Sanu has hauled in 14 catches for 172 yards (24.6 per game).
  • Kyle Juszczyk is averaging 20.9 receiving yards per game, racking up 15 receptions (17 targets) for 146 yards and one touchdown.
Select player props for the San Francisco 49ers
Name Pass Yds Pass TDs Rush Yds Rush TDs Rec Yds Rec TDs
Jimmy Garoppolo 232.5 (-113) 5.5 (-106)
Elijah Mitchell 74.5 (-117) 8.5 (-108)
Deebo Samuel 6.5 (-121) 78.5 (-113)


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