{"id":13862,"date":"2026-09-29T14:03:49","date_gmt":"2026-09-29T18:03:49","guid":{"rendered":"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/broncos-vs-49ers-prediction-picks-odds-week-4\/"},"modified":"2026-09-29T14:03:51","modified_gmt":"2026-09-29T18:03:51","slug":"broncos-vs-49ers-prediction-picks-odds-week-4","status":"publish","type":"nfl-news","link":"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/broncos-vs-49ers-prediction-picks-odds-week-4\/","title":{"rendered":"Broncos vs 49ers Prediction &#038; Picks: Week 4"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Our <strong>Broncos vs 49ers prediction<\/strong> covers the most complete team in the league. Squawka Signal&#8217;s live read updates on this page through the week.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The <a href=\"https:\/\/www.squawka.com\/ca\/nfl\/teams\/san-francisco-49ers\/\">San Francisco 49ers<\/a> are 3-0 with the best point differential in football at plus 48. The <a href=\"https:\/\/www.squawka.com\/ca\/nfl\/teams\/denver-broncos\/\">Denver Broncos<\/a> have allowed 431 rushing yards at 5.1 a carry. Levi&#8217;s Stadium hosts the widest gap in quality on the card.<\/p>\n\n\n\n<!-- SQ_NFL_SIGNAL -->\n\n\n\n<style>\n\/* Squawka NFL picks card - palette matched to the injected sq-nsig Signal units *\/\n.sqp{--cy:#2FE6C9;--val:#38D97A;--ovr:#FF6A5A;--fair:#FFC24B;--tx:#e8f0f7;--mut:rgba(232,240,247,.60);--line:rgba(255,255,255,.10);--gold:#FFC24B;position:relative;overflow:hidden;font-family:'Bricolage Grotesque',system-ui,-apple-system,Segoe UI,Roboto,sans-serif;color:var(--tx);max-width:960px;margin:14px auto 26px;border-radius:14px;background:linear-gradient(135deg,#0a2540 0%,#06182b 62%,#04121f 100%);box-shadow:0 14px 36px rgba(4,18,31,.34)}\n.sqp *{box-sizing:border-box}\n.sqp__wrap{padding:22px 26px 20px}\n.sqp__kick{display:inline-flex;align-items:center;gap:8px;font-size:11px;font-weight:800;letter-spacing:.14em;text-transform:uppercase;color:var(--cy)}\n.sqp__kick::before{content:'';width:7px;height:7px;border-radius:50%;background:var(--cy);box-shadow:0 0 9px 1px var(--cy)}\n.sqp__ttl{font-size:24px;font-weight:800;letter-spacing:-.3px;line-height:1.14;margin:12px 0 0;color:var(--tx)}\n.sqp__sub{margin:7px 0 0;font-size:14.5px;line-height:1.5;color:var(--mut);max-width:70ch}\n.sqp__crests{display:flex;align-items:center;gap:10px;margin-top:14px}\n.sqp__crests img{width:28px;height:28px;display:block}\n.sqp__at{font-size:12px;font-weight:700;color:var(--mut);letter-spacing:.1em}\n.sqp__h3{margin:20px 0 0;font-size:10.5px;font-weight:800;letter-spacing:.16em;text-transform:uppercase;color:var(--cy)}\n.sqp__list{margin-top:12px;border-top:1px solid var(--line)}\n.sqp__row{display:grid;grid-template-columns:1fr 126px;gap:14px;align-items:center;padding:14px 2px;border-bottom:1px solid var(--line)}\n.sqp__mkt{display:block;font-size:10px;font-weight:800;letter-spacing:.13em;text-transform:uppercase;color:var(--cy);margin-bottom:4px}\n.sqp__pk{font-size:15.5px;font-weight:800;line-height:1.25;color:var(--tx)}\n.sqp__top{display:inline-block;vertical-align:middle;margin-left:8px;font-size:9.5px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:#3a2c00;background:var(--gold);padding:3px 7px;border-radius:5px}\n.sqp__why{display:block;margin-top:5px;font-size:13.5px;line-height:1.5;color:var(--mut)}\n.sqp__pr{text-align:center}\n.sqp__val{display:block;font-size:23px;font-weight:800;color:var(--cy);line-height:1;text-decoration:none}\na.sqp__val:hover{text-decoration:underline}\n.sqp__stars{display:block;font-size:15px;line-height:1;letter-spacing:1px;color:var(--gold)}\n.sqp__stars .o{opacity:.55}\n.sqp__lab{display:block;font-size:10px;letter-spacing:.06em;text-transform:uppercase;color:var(--mut);margin-top:4px}\n.sqp__verd{display:inline-block;margin-top:6px;font-size:10.5px;font-weight:800;letter-spacing:.04em;padding:2px 7px;border-radius:5px}\n.sqp__verd--val{color:var(--val);background:rgba(56,217,122,.12)}\n.sqp__verd--ovr{color:var(--ovr);background:rgba(255,106,90,.12)}\n.sqp__verd--fair{color:var(--fair);background:rgba(255,194,75,.12)}\n.sqp__approach{margin:14px 0 0;font-size:13.5px;line-height:1.55;color:var(--tx)}\n.sqp__foot{margin:16px 0 0;padding-top:13px;border-top:1px solid var(--line);font-size:11.5px;line-height:1.55;color:rgba(232,240,247,.5)}\n.sqp__foot a{color:var(--cy);font-weight:700;text-decoration:none;border-bottom:1px solid rgba(47,230,201,.35)}\n@media(max-width:640px){\n.sqp__wrap{padding:18px 15px 16px}\n.sqp__ttl{font-size:20px}\n.sqp__row{grid-template-columns:1fr 100px;gap:10px}\n.sqp__val{font-size:20px}\n}\n<\/style>\n<div class=\"sqp\" id=\"sqp-densf\">\n<div class=\"sqp__wrap\">\n<span class=\"sqp__kick\">Week 4 &middot; Editorial pick<\/span>\n<h2 class=\"sqp__ttl\">Broncos vs 49ers: our editor&#8217;s props<\/h2>\n<p class=\"sqp__sub\">Two editorial calls to sit alongside the live Signal numbers on this page.<\/p>\n<div class=\"sqp__crests\">\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/ca\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/DEN.png\" alt=\"Broncos\" loading=\"lazy\" width=\"28\" height=\"28\">\n<span class=\"sqp__at\">AT<\/span>\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/ca\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"49ers\" loading=\"lazy\" width=\"28\" height=\"28\">\n<\/div>\n<h3 class=\"sqp__h3\">Our props<\/h3>\n<div class=\"sqp__list\">\n<div class=\"sqp__row\" data-market=\"Spread\" data-selection=\"San Francisco to win by 10 or more\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Spread<\/span><span class=\"sqp__pk\">San Francisco to win by 10 or more<\/span><span class=\"sqp__why\">San Francisco convert 63% on third down and 90% in the red zone, both league highs, and have conceded no sacks.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 5 of 5\">&#9733;&#9733;&#9733;&#9733;&#9733;<\/span><span class=\"sqp__lab\">5\/5 confidence<\/span><\/div>\n<\/div>\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"Brock Purdy 2+ passing touchdowns\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">Brock Purdy 2+ passing touchdowns<\/span><span class=\"sqp__why\">Purdy has nine touchdown passes to one interception at a 133.1 rating.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 4 of 5\">&#9733;&#9733;&#9733;&#9733;<span class=\"o\">&#9734;<\/span><\/span><span class=\"sqp__lab\">4\/5 confidence<\/span><\/div>\n<\/div>\n<\/div>\n<p class=\"sqp__foot\">An editorial call, not a Signal model output. 19+ (18+ in AB, MB and QC). Please play responsibly.<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Broncos vs 49ers: 2026 form so far<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">An unbeaten team with league-leading efficiency against a defence leaking on the ground. The table puts each attack against what the opposite side allows.<\/p>\n\n\n\n<h3>Broncos attack against the 49ers defence<\/h3>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Per game<\/th><th>Broncos offence<\/th><th>49ers allow<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Passing yards<\/td><td>194.0<\/td><td>207.3<\/td><\/tr>\n<tr><td>Rushing yards<\/td><td>81.0<\/td><td>105.7<\/td><\/tr>\n<tr><td>Yards per carry<\/td><td>3.6<\/td><td>3.7<\/td><\/tr>\n<tr><td>Passer rating<\/td><td>80.3<\/td><td>89.7<\/td><\/tr>\n<tr><td>Touchdowns<\/td><td>2.3<\/td><td>1.7<\/td><\/tr>\n<tr><td>Third-down conversion<\/td><td>36.1%<\/td><td>42.9%<\/td><\/tr>\n<tr><td>Red-zone conversion<\/td><td>60.0%<\/td><td>40.0%<\/td><\/tr>\n<tr><td>Sacks conceded \/ recorded<\/td><td>1.7<\/td><td>2.0<\/td><\/tr>\n<\/tbody><\/table><\/figure>\n<h3>49ers attack against the Broncos defence<\/h3>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Per game<\/th><th>49ers offence<\/th><th>Broncos allow<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Passing yards<\/td><td>263.0<\/td><td>237.0<\/td><\/tr>\n<tr><td>Rushing yards<\/td><td>136.3<\/td><td>143.7<\/td><\/tr>\n<tr><td>Yards per carry<\/td><td>5.1<\/td><td>5.1<\/td><\/tr>\n<tr><td>Passer rating<\/td><td>133.1<\/td><td>74.3<\/td><\/tr>\n<tr><td>Touchdowns<\/td><td>4.3<\/td><td>2.3<\/td><\/tr>\n<tr><td>Third-down conversion<\/td><td>63.0%<\/td><td>47.8%<\/td><\/tr>\n<tr><td>Red-zone conversion<\/td><td>90.0%<\/td><td>45.5%<\/td><\/tr>\n<tr><td>Sacks conceded \/ recorded<\/td><td>0.0<\/td><td>2.7<\/td><\/tr>\n<\/tbody><\/table><\/figure>\n<p><em>Read these as a 3-game sample rather than settled form. Rates this early move a long way on one result.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">San Francisco have conceded no sacks and convert 90% of red-zone trips. Denver concede 5.1 a carry.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Broncos vs 49ers quarterback matchup<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Brock Purdy sits at a 133.1 rating for the season. Bo Nix is at 80.3 from 10 more attempts.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table><thead><tr><th>Team<\/th><th>Quarterback<\/th><th>Last game<\/th><th>Season to date<\/th><\/tr><\/thead><tbody><tr><td>Broncos<\/td><td>Bo Nix<\/td><td>17\/34, 186 yds, 2 TD, 1 INT, 73.9 rtg<\/td><td>56\/93, 605 yds, 4 TD, 3 INT, 80.3 rtg (3 games)<\/td><\/tr><tr><td>49ers<\/td><td>Brock Purdy<\/td><td>15\/27, 297 yds, 4 TD, 0 INT, 133.8 rtg<\/td><td>60\/83, 789 yds, 9 TD, 1 INT, 133.1 rtg (3 games)<\/td><\/tr><\/tbody><\/table><figcaption>Last game is Week 3. Season figures are 2026 to date, with games played in brackets.<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Broncos vs 49ers injury report and team news<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Jonathon Cooper is on the exempt list for Denver after recording eight sacks last season.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">George Kittle caught six passes for 82 yards and two touchdowns against Arizona.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This section updates as soon as the Out, Doubtful and Questionable tags land.<\/p>\n\n\n\n<!-- SQ_NFL_INJURIES -->\n\n\n\n<h2 class=\"wp-block-heading\">Where Broncos vs 49ers is decided<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">San Francisco are the only team yet to concede a sack. That protection is why Purdy has nine touchdown passes and one interception.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Denver&#8217;s defence has eight sacks and four interceptions, and they beat the Rams 30-26. The run defence is the exception, at 431 yards allowed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">San Francisco run at 5.1 a carry themselves, which is precisely the weakness on offer.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Players to watch<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Bo Nix (DEN, QB):<\/strong> 186 yards and two touchdowns against the Rams.<\/li>\n<li><strong>Courtland Sutton (DEN, WR):<\/strong> Three catches for 46 yards in Week 3.<\/li>\n<li><strong>Brock Purdy (SF, QB):<\/strong> 297 yards and four touchdowns against Arizona.<\/li>\n<li><strong>George Kittle (SF, TE):<\/strong> Six catches for 82 yards and two touchdowns in Week 3.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to watch Broncos vs 49ers<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Kickoff is 4:25 PM ET on Sunday 4 October at Levi&#8217;s Stadium, which is 3:25 PM CT and 1:25 PM PT. CTV coverage is regional, so the fixture on your local CTV station depends where you are, with TSN alongside it and RDS in French. <a href=\"https:\/\/tidd.ly\/3SXLgWO\" rel=\"sponsored nofollow noopener\" target=\"_blank\">DAZN<\/a> carries every game of the season in Canada. Squawka may earn a commission if you subscribe through that link.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr><th>Detail<\/th><th>Broncos vs 49ers<\/th><\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Date<\/strong><\/td><td>Sunday, October 4, 2026<\/td><\/tr>\n<tr><td><strong>Kickoff<\/strong><\/td><td>4:25 PM ET \/ 3:25 PM CT \/ 1:25 PM PT<\/td><\/tr>\n<tr><td><strong>Venue<\/strong><\/td><td>Levi&#8217;s Stadium, Santa Clara, CA<\/td><\/tr>\n<tr><td><strong>TV<\/strong><\/td><td>CTV (regional) \/ TSN \/ RDS (French)<\/td><\/tr>\n<tr><td><strong>Live stream<\/strong><\/td><td><a href=\"https:\/\/tidd.ly\/3SXLgWO\" rel=\"sponsored nofollow noopener\" target=\"_blank\">DAZN<\/a><\/td><\/tr>\n<tr><td><strong>Week<\/strong><\/td><td>Week 4, 2026 NFL season<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Broncos vs 49ers prediction and score projection<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Our <strong>Broncos vs 49ers prediction<\/strong> is a San Francisco win, 31-17, rated 5\/5. It is the only maximum-confidence call of the round.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The live win probability and the model&#8217;s projected margin update on this page through the week.<\/p>\n\n\n\n<h2>Every Week 4 game, previewed<\/h2>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Kickoff (ET)<\/th><th>Game<\/th><th>Our prediction<\/th><th>Preview<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Thu 8:15 PM<\/td><td>Steelers @ Browns<\/td><td>Browns 20-17<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/steelers-vs-browns-prediction-picks-odds-week-4\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 9:30 AM<\/td><td>Colts @ Commanders<\/td><td>Commanders 27-24<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/colts-vs-commanders-prediction-picks-odds-week-4\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Cardinals @ Giants<\/td><td>Cardinals 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/cardinals-vs-giants-prediction-picks-odds-week-4\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Cowboys @ Texans<\/td><td>Cowboys 27-24<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/cowboys-vs-texans-prediction-picks-odds-week-4\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Packers @ Buccaneers<\/td><td>Packers 23-20<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/packers-vs-buccaneers-prediction-picks-odds-week-4\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Jaguars @ Bengals<\/td><td>Jaguars 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/jaguars-vs-bengals-prediction-picks-odds-week-4\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Rams @ Eagles<\/td><td>Rams 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/rams-vs-eagles-prediction-picks-odds-week-4\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Patriots @ Bills<\/td><td>Bills 30-16<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/patriots-vs-bills-prediction-picks-odds-week-4\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Jets @ Bears<\/td><td>Bears 27-24<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/jets-vs-bears-prediction-picks-odds-week-4\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Titans @ Ravens<\/td><td>Ravens 27-13<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/titans-vs-ravens-prediction-picks-odds-week-4\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:05 PM<\/td><td>Dolphins @ Vikings<\/td><td>Vikings 24-13<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/dolphins-vs-vikings-prediction-picks-odds-week-4\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:25 PM<\/td><td><strong>Broncos @ 49ers<\/strong><\/td><td>49ers 31-17<\/td><td><em>You are here<\/em><\/td><\/tr>\n<tr><td>Sun 4:25 PM<\/td><td>Chiefs @ Raiders<\/td><td>Chiefs 27-24<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/chiefs-vs-raiders-prediction-picks-odds-week-4\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:25 PM<\/td><td>Chargers @ Seahawks<\/td><td>Seahawks 27-17<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/chargers-vs-seahawks-prediction-picks-odds-week-4\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 8:20 PM<\/td><td>Lions @ Panthers<\/td><td>Lions 31-24<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/lions-vs-panthers-prediction-picks-odds-week-4\/\">Read<\/a><\/td><\/tr>\n<tr><td>Mon 8:15 PM<\/td><td>Falcons @ Saints<\/td><td>Saints 26-23<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/falcons-vs-saints-prediction-picks-odds-week-4\/\">Read<\/a><\/td><\/tr>\n<\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Every fixture in the round is covered across our <a href=\"\/ca\/nfl\/\">NFL hub<\/a>, and Signal rates <a href=\"\/ca\/nfl\/picks\/\">every Week 4 game<\/a> the same way. This one crosses the conferences, so the <a href=\"\/ca\/nfl\/afc-championship-odds\/\">AFC Championship odds<\/a> and the <a href=\"\/ca\/nfl\/nfc-championship-odds\/\">NFC Championship odds<\/a> are both worth a look as the season develops.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Broncos vs 49ers FAQ<\/h2>\n\n\n\n<div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-densf-1\"><strong class=\"schema-faq-question\">Who is favoured to win, the Broncos or the 49ers?<\/strong> <p class=\"schema-faq-answer\">San Francisco, comfortably, at home. The 49ers are 3-0 with the best point differential in the league.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-densf-2\"><strong class=\"schema-faq-question\">What time is Broncos vs 49ers in Canada?<\/strong> <p class=\"schema-faq-answer\">4:25 PM ET on Sunday 4 October, which is 3:25 PM CT and 1:25 PM PT.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-densf-3\"><strong class=\"schema-faq-question\">How can I watch Broncos vs 49ers in Canada?<\/strong> <p class=\"schema-faq-answer\">CTV coverage is regional, so the fixture on your local CTV station depends where you are, with TSN alongside it and RDS in French. DAZN carries every game of the season in Canada.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-densf-4\"><strong class=\"schema-faq-question\">Have the 49ers conceded a sack this season?<\/strong> <p class=\"schema-faq-answer\">No. They are the only team in the league yet to concede one.<\/p><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>19+ (18+ in AB, MB and QC) | Please play responsibly | ConnexOntario: 1-866-531-2600 (ON) | Signal probabilities approximate at time of writing and subject to change<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our Broncos vs 49ers prediction covers the most complete team in the league. Squawka Signal&#8217;s live read updates on this page through the week. The San Francisco 49ers are 3-0 with the best point differential in football at plus 48. The Denver Broncos have allowed 431 rushing yards at 5.1 a carry. Levi&#8217;s Stadium hosts&#8230;<\/p>\n","protected":false},"author":394,"featured_media":13830,"menu_order":0,"template":"","meta":{"_acf_changed":false,"_yoast_wpseo_focuskw":"broncos vs 49ers prediction","_yoast_wpseo_title":"Broncos vs 49ers Prediction & Picks: Week 4 | Squawka","_yoast_wpseo_metadesc":"Our Broncos vs 49ers prediction and picks for Week 4 in Santa Clara, where San Francisco have not conceded a sack all season.","footnotes":""},"tags":[339,328,357],"class_list":["post-13862","nfl-news","type-nfl-news","status-publish","has-post-thumbnail","hentry","tag-denver-broncos","tag-nfl","tag-san-francisco-49ers"],"acf":{"external_featured_image_url":"","hide_featured_image_pattern":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Broncos vs 49ers Prediction &amp; Picks: Week 4 | Squawka<\/title>\n<meta name=\"description\" content=\"Our Broncos vs 49ers prediction and picks for Week 4 in Santa Clara, where San Francisco have not conceded a sack all season.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/broncos-vs-49ers-prediction-picks-odds-week-4\/\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Broncos vs 49ers Prediction &amp; 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