{"id":12641,"date":"2026-09-22T13:04:11","date_gmt":"2026-09-22T17:04:11","guid":{"rendered":"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/cardinals-vs-49ers-prediction-picks-odds-week-3\/"},"modified":"2026-09-22T13:04:12","modified_gmt":"2026-09-22T17:04:12","slug":"cardinals-vs-49ers-prediction-picks-odds-week-3","status":"publish","type":"nfl-news","link":"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/cardinals-vs-49ers-prediction-picks-odds-week-3\/","title":{"rendered":"Cardinals vs 49ers Prediction &#038; Picks"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Our <strong>Cardinals vs 49ers prediction<\/strong> is the most one-sided read of the late afternoon. Squawka Signal&#8217;s live read updates on this page through the week.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The <a href=\"https:\/\/www.squawka.com\/ca\/nfl\/teams\/arizona-cardinals\/\">Arizona Cardinals<\/a> gained 151 yards at home against Seattle and held the ball for under 24 minutes. The <a href=\"https:\/\/www.squawka.com\/ca\/nfl\/teams\/san-francisco-49ers\/\">San Francisco 49ers<\/a> are scoring on 87.5% of their red-zone trips. The divisional tie does little to close that.<\/p>\n\n\n\n<!-- SQ_NFL_SIG_START -->\n\n<style>\n.sq-nsig{position:relative;overflow:hidden;border-radius:18px;margin:28px 0;isolation:isolate;background:radial-gradient(70% 90% at 18% 0%,rgba(47,230,201,.14) 0%,rgba(47,230,201,0) 60%),linear-gradient(135deg,#0a2540 0%,#06182b 60%,#040f1d 100%);box-shadow:0 18px 44px rgba(4,15,29,.5);font-family:'Bricolage 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a{color:#2FE6C9;text-decoration:underline}\n@media(max-width:560px){.sq-nsig__inner{padding:22px 16px}.sq-nsig__cmp{gap:10px}.sq-nsig__verd{min-width:0}.sq-nsig__name{font-size:14px}}\n.sq-nsig__geo-r{position:absolute;width:0;height:0;opacity:0;pointer-events:none}\n.sq-nsig__geo-tabs{display:inline-flex;border:1px solid rgba(47,230,201,.4);border-radius:999px;overflow:hidden;margin:0 0 14px}\n.sq-nsig__geo-tab{cursor:pointer;padding:6px 15px;font-size:11px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:rgba(232,240,247,.6)}\n.sq-nsig__geo-a{display:contents}.sq-nsig__geo-b{display:none}\n.sq-nsig__geo-r--a:checked~.sq-nsig__geo-tabs .sq-nsig__geo-tab--a,.sq-nsig__geo-r--b:checked~.sq-nsig__geo-tabs .sq-nsig__geo-tab--b{background:#2FE6C9;color:#04121f}\n.sq-nsig__geo-r--b:checked~.sq-nsig__cards .sq-nsig__geo-a,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-a{display:none}\n.sq-nsig__geo-r--b:checked~.sq-nsig__cards .sq-nsig__geo-b,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-b{display:contents}\n<\/style>\n<div class=\"sq-nsig\"><div class=\"sq-nsig__inner\"><span class=\"sq-nsig__tag\"><span class=\"dot\"><\/span>Squawka Signal &middot; Model read<\/span><h3 class=\"sq-nsig__title\">Arizona Cardinals @ San Francisco 49ers<\/h3><p class=\"sq-nsig__meta\">Week 3 &middot; Sun Sep 27, 4:05 PM ET. Our Signal model makes the <b>San Francisco 49ers<\/b> favourites by about <b>9<\/b> points, a 79% win probability.<\/p><div class=\"sq-nsig__cards\"><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/ARI.png\" alt=\"ARI\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">Arizona Cardinals<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Win prob<\/span><span class=\"sq-nsig__cmp-sig\">21%<\/span><\/span><\/span><\/div><\/div><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"SF\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">San Francisco 49ers<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Win prob<\/span><span class=\"sq-nsig__cmp-sig\">79%<\/span><\/span><\/span><\/div><\/div><\/div><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Projected line<\/span><span class=\"sq-nsig__mc-v\">San Francisco 49ers -9<\/span><\/div><div class=\"sq-nsig__cta-row\" style=\"margin-top:14px\"><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/bet365?q=ca-all-tmp-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">bet365<\/a><\/div><p class=\"sq-nsig__foot\">Squawka Signal is our model&#8217;s read, updated after every result &mdash; not betting advice. <a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/nfl-signal-methodology\/\">How the NFL Signal works<\/a>. 19+ (18+ in AB\/MB\/QC). Please play responsibly. ConnexOntario: 1-866-531-2600 (ON). 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palette matched to the injected sq-nsig Signal units *\/\n.sqp{--cy:#2FE6C9;--val:#38D97A;--ovr:#FF6A5A;--fair:#FFC24B;--tx:#e8f0f7;--mut:rgba(232,240,247,.60);--line:rgba(255,255,255,.10);--gold:#FFC24B;position:relative;overflow:hidden;font-family:'Bricolage Grotesque',system-ui,-apple-system,Segoe UI,Roboto,sans-serif;color:var(--tx);max-width:960px;margin:14px auto 26px;border-radius:14px;background:linear-gradient(135deg,#0a2540 0%,#06182b 62%,#04121f 100%);box-shadow:0 14px 36px rgba(4,18,31,.34)}\n.sqp *{box-sizing:border-box}\n.sqp__wrap{padding:22px 26px 20px}\n.sqp__kick{display:inline-flex;align-items:center;gap:8px;font-size:11px;font-weight:800;letter-spacing:.14em;text-transform:uppercase;color:var(--cy)}\n.sqp__kick::before{content:'';width:7px;height:7px;border-radius:50%;background:var(--cy);box-shadow:0 0 9px 1px var(--cy)}\n.sqp__ttl{font-size:24px;font-weight:800;letter-spacing:-.3px;line-height:1.14;margin:12px 0 0;color:var(--tx)}\n.sqp__sub{margin:7px 0 0;font-size:14.5px;line-height:1.5;color:var(--mut);max-width:70ch}\n.sqp__crests{display:flex;align-items:center;gap:10px;margin-top:14px}\n.sqp__crests img{width:28px;height:28px;display:block}\n.sqp__at{font-size:12px;font-weight:700;color:var(--mut);letter-spacing:.1em}\n.sqp__h3{margin:20px 0 0;font-size:10.5px;font-weight:800;letter-spacing:.16em;text-transform:uppercase;color:var(--cy)}\n.sqp__list{margin-top:12px;border-top:1px solid var(--line)}\n.sqp__row{display:grid;grid-template-columns:1fr 126px;gap:14px;align-items:center;padding:14px 2px;border-bottom:1px solid var(--line)}\n.sqp__mkt{display:block;font-size:10px;font-weight:800;letter-spacing:.13em;text-transform:uppercase;color:var(--cy);margin-bottom:4px}\n.sqp__pk{font-size:15.5px;font-weight:800;line-height:1.25;color:var(--tx)}\n.sqp__top{display:inline-block;vertical-align:middle;margin-left:8px;font-size:9.5px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:#3a2c00;background:var(--gold);padding:3px 7px;border-radius:5px}\n.sqp__why{display:block;margin-top:5px;font-size:13.5px;line-height:1.5;color:var(--mut)}\n.sqp__pr{text-align:center}\n.sqp__val{display:block;font-size:23px;font-weight:800;color:var(--cy);line-height:1;text-decoration:none}\na.sqp__val:hover{text-decoration:underline}\n.sqp__stars{display:block;font-size:15px;line-height:1;letter-spacing:1px;color:var(--gold)}\n.sqp__stars .o{opacity:.55}\n.sqp__lab{display:block;font-size:10px;letter-spacing:.06em;text-transform:uppercase;color:var(--mut);margin-top:4px}\n.sqp__verd{display:inline-block;margin-top:6px;font-size:10.5px;font-weight:800;letter-spacing:.04em;padding:2px 7px;border-radius:5px}\n.sqp__verd--val{color:var(--val);background:rgba(56,217,122,.12)}\n.sqp__verd--ovr{color:var(--ovr);background:rgba(255,106,90,.12)}\n.sqp__verd--fair{color:var(--fair);background:rgba(255,194,75,.12)}\n.sqp__approach{margin:14px 0 0;font-size:13.5px;line-height:1.55;color:var(--tx)}\n.sqp__foot{margin:16px 0 0;padding-top:13px;border-top:1px solid var(--line);font-size:11.5px;line-height:1.55;color:rgba(232,240,247,.5)}\n.sqp__foot a{color:var(--cy);font-weight:700;text-decoration:none;border-bottom:1px solid rgba(47,230,201,.35)}\n@media(max-width:640px){\n.sqp__wrap{padding:18px 15px 16px}\n.sqp__ttl{font-size:20px}\n.sqp__row{grid-template-columns:1fr 100px;gap:10px}\n.sqp__val{font-size:20px}\n}\n<\/style>\n<div class=\"sqp\" id=\"sqp-arisf\">\n<div class=\"sqp__wrap\">\n<span class=\"sqp__kick\">Week 3 &middot; Editorial pick<\/span>\n<h2 class=\"sqp__ttl\">Cardinals vs 49ers: our editor&#8217;s props<\/h2>\n<p class=\"sqp__sub\">Two editorial calls to sit alongside the live Signal numbers on this page.<\/p>\n<div class=\"sqp__crests\">\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/ca\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/ARI.png\" alt=\"Cardinals\" loading=\"lazy\" width=\"28\" height=\"28\">\n<span class=\"sqp__at\">AT<\/span>\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/ca\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"49ers\" loading=\"lazy\" width=\"28\" height=\"28\">\n<\/div>\n<h3 class=\"sqp__h3\">Our props<\/h3>\n<div class=\"sqp__list\">\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"Brock Purdy 2+ passing touchdowns\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">Brock Purdy 2+ passing touchdowns<\/span><span class=\"sqp__why\">Purdy threw two at a 149.1 rating against Miami and San Francisco have five touchdown passes in two games. Arizona have conceded four and a 110.9 rating.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 4 of 5\">&#9733;&#9733;&#9733;&#9733;<span class=\"o\">&#9734;<\/span><\/span><span class=\"sqp__lab\">4\/5 confidence<\/span><\/div>\n<\/div>\n<div class=\"sqp__row\" data-market=\"Team total\" data-selection=\"Arizona under 18.5 points\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Team total<\/span><span class=\"sqp__pk\">Arizona under 18.5 points<\/span><span class=\"sqp__why\">The Cardinals gained 151 yards against Seattle and have three touchdowns all season. San Francisco have conceded two.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 3 of 5\">&#9733;&#9733;&#9733;<span class=\"o\">&#9734;&#9734;<\/span><\/span><span class=\"sqp__lab\">3\/5 confidence<\/span><\/div>\n<\/div>\n<\/div>\n<p class=\"sqp__foot\">An editorial call, not a Signal model output. 19+ (18+ in AB, MB and QC). Please play responsibly.<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs 49ers: 2026 form so far<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">An unbeaten side against one that has just been dismantled at home. Each attack is set against what the opposite defence has allowed.<\/p>\n\n\n\n<h3>Cardinals attack against the 49ers defence<\/h3>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Per game<\/th><th>Cardinals offence<\/th><th>49ers allow<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Passing yards<\/td><td>179.0<\/td><td>175.0<\/td><\/tr>\n<tr><td>Rushing yards<\/td><td>93.0<\/td><td>112.0<\/td><\/tr>\n<tr><td>Yards per carry<\/td><td>3.6<\/td><td>3.9<\/td><\/tr>\n<tr><td>Passer rating<\/td><td>86.2<\/td><td>80.9<\/td><\/tr>\n<tr><td>Touchdowns<\/td><td>1.5<\/td><td>1.0<\/td><\/tr>\n<tr><td>Third-down conversion<\/td><td>34.6%<\/td><td>37.5%<\/td><\/tr>\n<tr><td>Red-zone conversion<\/td><td>50.0%<\/td><td>20.0%<\/td><\/tr>\n<tr><td>Sacks conceded \/ recorded<\/td><td>1.5<\/td><td>2.0<\/td><\/tr>\n<\/tbody><\/table><\/figure>\n<h3>49ers attack against the Cardinals defence<\/h3>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Per game<\/th><th>49ers offence<\/th><th>Cardinals allow<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Passing yards<\/td><td>246.0<\/td><td>203.0<\/td><\/tr>\n<tr><td>Rushing yards<\/td><td>134.5<\/td><td>121.5<\/td><\/tr>\n<tr><td>Yards per carry<\/td><td>4.7<\/td><td>4.0<\/td><\/tr>\n<tr><td>Passer rating<\/td><td>125.6<\/td><td>110.9<\/td><\/tr>\n<tr><td>Touchdowns<\/td><td>4.0<\/td><td>3.0<\/td><\/tr>\n<tr><td>Third-down conversion<\/td><td>63.2%<\/td><td>38.1%<\/td><\/tr>\n<tr><td>Red-zone conversion<\/td><td>87.5%<\/td><td>62.5%<\/td><\/tr>\n<tr><td>Sacks conceded \/ recorded<\/td><td>0.0<\/td><td>2.0<\/td><\/tr>\n<\/tbody><\/table><\/figure>\n<p><em>Read these as a 2-game sample rather than settled form. Rates this early move a long way on one result.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">San Francisco convert 63.2% on third down. Arizona convert 34.6% and have conceded a 110.9 passer rating.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs 49ers injury report and team news<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">George Kittle caught four passes for 80 yards and a touchdown against Miami.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Arizona have taken 14 penalties for 159 yards in two games, among the heaviest totals in the league.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This section updates as soon as the Out, Doubtful and Questionable tags land.<\/p>\n\n\n\n<!-- SQ_NFL_INJ_START -->\n\n<style>\n.sq-ninj{border:1px solid #123f5c;border-radius:14px;overflow:hidden;margin:24px 0;font-family:'Bricolage Grotesque',system-ui,-apple-system,sans-serif;background:#0a2540;color:#e8f0f7}\n.sq-ninj__head{display:flex;align-items:baseline;justify-content:space-between;gap:10px;padding:13px 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auto;color:rgba(232,240,247,.5);font-size:11px}\n.sq-ninj__st{flex:0 0 auto;font-size:10.5px;font-weight:800;letter-spacing:.04em;text-transform:uppercase;padding:3px 9px;border-radius:999px}\n.sq-ninj__st--out{background:rgba(255,106,90,.16);color:#FF6A5A}\n.sq-ninj__st--doubt{background:rgba(255,194,75,.16);color:#FFC24B}\n.sq-ninj__st--ques{background:rgba(232,240,247,.1);color:rgba(232,240,247,.8)}\n.sq-ninj__st--lt{background:rgba(160,180,200,.14);color:rgba(232,240,247,.82);border:1px solid rgba(232,240,247,.18)}\n.sq-ninj__lt{margin-top:11px;padding-top:9px;border-top:1px solid rgba(255,255,255,.12)}\n.sq-ninj__lt-h{font-size:10px;font-weight:800;letter-spacing:.06em;text-transform:uppercase;color:rgba(232,240,247,.5);margin-bottom:3px}\n.sq-ninj__none{font-size:13px;color:rgba(232,240,247,.55);padding:4px 0}\n@media(max-width:520px){.sq-ninj__col+.sq-ninj__col{border-left:0;border-top:1px solid #123f5c}}\n<\/style><div class=\"sq-ninj\"><div class=\"sq-ninj__head\">Injury report &middot; Week 3<span>Official game-status report &mdash; updates through the week<\/span><\/div><div class=\"sq-ninj__cols\"><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/ARI.png\" alt=\"ARI\" loading=\"lazy\" width=\"24\" height=\"24\">Arizona Cardinals<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><div class=\"sq-ninj__lt\"><div class=\"sq-ninj__lt-h\">Out long-term<\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Kaleb Proctor<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Zach Carter<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Chase Bisontis<\/span><span class=\"sq-ninj__pos\">OL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">James Conner<\/span><span class=\"sq-ninj__pos\">RB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Trey Benson<\/span><span class=\"sq-ninj__pos\">RB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Joey Blount<\/span><span class=\"sq-ninj__pos\">SAF<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Kitan Crawford<\/span><span class=\"sq-ninj__pos\">SAF<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Jameson Geers<\/span><span class=\"sq-ninj__pos\">TE<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Tip Reiman<\/span><span class=\"sq-ninj__pos\">TE<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">PUP<\/span><\/div><\/div><\/div><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"SF\" loading=\"lazy\" width=\"24\" height=\"24\">San Francisco 49ers<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><div class=\"sq-ninj__lt\"><div class=\"sq-ninj__lt-h\">Out long-term<\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Nate Hobbs<\/span><span class=\"sq-ninj__pos\">CB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Alfred Collins<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Andrew Farmer II<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Mikail Kamara<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Sam Okuayinonu<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Nick Martin<\/span><span class=\"sq-ninj__pos\">LB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Austen Pleasants<\/span><span class=\"sq-ninj__pos\">OL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Brett Toth<\/span><span class=\"sq-ninj__pos\">OL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Nick Zakelj<\/span><span class=\"sq-ninj__pos\">OL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Darrick Forrest<\/span><span class=\"sq-ninj__pos\">SAF<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Jake Tonges<\/span><span class=\"sq-ninj__pos\">TE<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Christian Kirk<\/span><span class=\"sq-ninj__pos\">WR<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">De&#8217;Zhaun Stribling<\/span><span class=\"sq-ninj__pos\">WR<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Ricky Pearsall<\/span><span class=\"sq-ninj__pos\">WR<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Mykel Williams<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">PUP<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Isaac Guerendo<\/span><span class=\"sq-ninj__pos\">RB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">PUP<\/span><\/div><\/div><\/div><\/div><\/div>\n\n<!-- SQ_NFL_INJ_END -->\n\n\n\n<h2 class=\"wp-block-heading\">The matchup that settles it: San Francisco&#8217;s third-down rate<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Sixty-three per cent on third down keeps drives alive and keeps Arizona&#8217;s offence watching, which is exactly what happened to the Cardinals against Seattle.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Arizona&#8217;s best hope is Trey McBride, their most targeted player and the only one producing consistently.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">San Francisco have conceded two touchdowns in two games and hold opponents to 20% in the red zone.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Players to watch<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Trey McBride (ARI, TE):<\/strong> Eight catches and a touchdown against Seattle.<\/li>\n<li><strong>Jacoby Brissett (ARI, QB):<\/strong> 95 passing yards in Week 2, from 28 attempts.<\/li>\n<li><strong>Brock Purdy (SF, QB):<\/strong> 287 yards and two touchdowns at a 149.1 rating against Miami.<\/li>\n<li><strong>George Kittle (SF, TE):<\/strong> Four catches for 80 yards and a score in Week 2.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to watch Cardinals vs 49ers<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The game kicks off at 4:05 PM ET on Sunday, September 27, which is 3:05 PM CT and 1:05 PM PT. CTV has the regional broadcast and RDS the French-language call, and <a href=\"https:\/\/tidd.ly\/3SXLgWO\" rel=\"sponsored nofollow noopener\" target=\"_blank\">DAZN<\/a> carries every game of the season. Squawka may earn a commission if you subscribe through that link.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr><th>Detail<\/th><th>Cardinals vs 49ers<\/th><\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Date<\/strong><\/td><td>Sunday, September 27, 2026<\/td><\/tr>\n<tr><td><strong>Kickoff<\/strong><\/td><td>4:05 PM ET \/ 3:05 PM CT \/ 1:05 PM PT<\/td><\/tr>\n<tr><td><strong>Venue<\/strong><\/td><td>Levi&#8217;s Stadium, Santa Clara, CA<\/td><\/tr>\n<tr><td><strong>TV<\/strong><\/td><td>CTV (regional) \/ RDS (French)<\/td><\/tr>\n<tr><td><strong>Live stream<\/strong><\/td><td><a href=\"https:\/\/tidd.ly\/3SXLgWO\" rel=\"sponsored nofollow noopener\" target=\"_blank\">DAZN (NFL Game Pass) \/ CTV.ca<\/a><\/td><\/tr>\n<tr><td><strong>Week<\/strong><\/td><td>Week 2, 2026 NFL season<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs 49ers prediction and score projection<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Our <strong>Cardinals vs 49ers prediction<\/strong> is a San Francisco win, 30-13. The 49ers are the better side in every phase.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Signal&#8217;s live number updates on this page through the week.<\/p>\n\n\n\n<h2>Every Week 3 game, previewed<\/h2>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Kickoff (ET)<\/th><th>Game<\/th><th>Our prediction<\/th><th>Preview<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Thu 8:15 PM<\/td><td>Falcons @ Packers<\/td><td>Packers 23-10<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/falcons-vs-packers-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Panthers @ Browns<\/td><td>Panthers 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/panthers-vs-browns-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Bengals @ Steelers<\/td><td>Bengals 20-13<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/bengals-vs-steelers-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Texans @ Colts<\/td><td>Colts 26-20<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/texans-vs-colts-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Chiefs @ Dolphins<\/td><td>Chiefs 31-17<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/chiefs-vs-dolphins-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Chargers @ Bills<\/td><td>Bills 31-20<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/chargers-vs-bills-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Patriots @ Jaguars<\/td><td>Patriots 20-16<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/patriots-vs-jaguars-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Jets @ Lions<\/td><td>Lions 27-20<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/jets-vs-lions-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Seahawks @ Commanders<\/td><td>Seahawks 27-17<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/seahawks-vs-commanders-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Titans @ Giants<\/td><td>Titans 20-17<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/titans-vs-giants-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:05 PM<\/td><td><strong>Cardinals @ 49ers<\/strong><\/td><td>49ers 30-13<\/td><td><em>You are here<\/em><\/td><\/tr>\n<tr><td>Sun 4:05 PM<\/td><td>Vikings @ Buccaneers<\/td><td>Vikings 20-17<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/vikings-vs-buccaneers-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:25 PM<\/td><td>Ravens @ Cowboys<\/td><td>Ravens 30-24<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/ravens-vs-cowboys-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:25 PM<\/td><td>Raiders @ Saints<\/td><td>Raiders 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/raiders-vs-saints-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 8:20 PM<\/td><td>Rams @ Broncos<\/td><td>Rams 26-17<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/rams-vs-broncos-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Mon 8:15 PM<\/td><td>Eagles @ Bears<\/td><td>Eagles 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/ca\/nfl\/nfl-news\/eagles-vs-bears-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Every fixture in the round is covered across our <a href=\"\/ca\/nfl\/\">NFL hub<\/a>, and Signal rates <a href=\"\/ca\/nfl\/picks\/\">every Week 3 game<\/a> the same way. Compare the <a href=\"\/ca\/outright-markets\/afc-championship-odds\/\">AFC Championship odds<\/a> and <a href=\"\/ca\/outright-markets\/nfc-championship-odds\/\">NFC Championship odds<\/a> as the season develops, and our <a href=\"\/ca\/nfl\/nfl-news\/how-to-watch-nfl-in-canada\/\">guide to watching the NFL in Canada<\/a> covers every window.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs 49ers FAQ<\/h2>\n\n\n\n<div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-arisf-1\"><strong class=\"schema-faq-question\">Who is favoured to win, the Cardinals or the 49ers?<\/strong> <p class=\"schema-faq-answer\">San Francisco, at home. The 49ers are 2-0 and have conceded two touchdowns.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-arisf-2\"><strong class=\"schema-faq-question\">What time is Cardinals vs 49ers in Canada?<\/strong> <p class=\"schema-faq-answer\">4:05 PM ET on Sunday, September 27, which is 3:05 PM CT and 1:05 PM PT.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-arisf-3\"><strong class=\"schema-faq-question\">What channel is Cardinals vs 49ers on in Canada?<\/strong> <p class=\"schema-faq-answer\">CTV has the regional broadcast and RDS the French. DAZN streams it too.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-arisf-4\"><strong class=\"schema-faq-question\">How did each side do in Week 2?<\/strong> <p class=\"schema-faq-answer\">Arizona lost 31-7 at home to Seattle. San Francisco beat Miami 35-13.<\/p><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>19+ (18+ in AB, MB and QC) | Please play responsibly | ConnexOntario: 1-866-531-2600 (ON) | Signal probabilities approximate at time of writing and subject to change<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our Cardinals vs 49ers prediction is the most one-sided read of the late afternoon. Squawka Signal&#8217;s live read updates on this page through the week. The Arizona Cardinals gained 151 yards at home against Seattle and held the ball for under 24 minutes. The San Francisco 49ers are scoring on 87.5% of their red-zone trips&#8230;.<\/p>\n","protected":false},"author":394,"featured_media":12608,"menu_order":0,"template":"","meta":{"_acf_changed":false,"_yoast_wpseo_focuskw":"cardinals vs 49ers prediction","_yoast_wpseo_title":"Cardinals vs 49ers Prediction & Picks | Squawka","_yoast_wpseo_metadesc":"Our Cardinals vs 49ers prediction, picks and odds for Week 3 at Levi's Stadium. Arizona managed 151 yards against Seattle.","footnotes":""},"tags":[330,328,357],"class_list":["post-12641","nfl-news","type-nfl-news","status-publish","has-post-thumbnail","hentry","tag-arizona-cardinals","tag-nfl","tag-san-francisco-49ers"],"acf":{"external_featured_image_url":"","hide_featured_image_pattern":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Cardinals vs 49ers Prediction &amp; Picks | Squawka<\/title>\n<meta name=\"description\" content=\"Our Cardinals vs 49ers prediction, picks and odds for Week 3 at Levi&#039;s Stadium. 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