The Frenchman’s place in the starting XI has come under question in recent weeks but he was expected to start against rivals Liverpool.
But now, Juan Mata has taken his place in midfield sitting ahead of Scott McTominay and Nemanja Matic.
Three changes to #MUFC's starting XI for today's game v Liverpool…
— Manchester United (@ManUtd) March 10, 2018
There is also a first Premier League start since November for centre-back Eric Bailly who has fully recovered from an ankle injury, replacing Victor Lindelof in defence.
Alexis Sanchez continues in attack for United despite a poor start to life at Old Trafford, providing cover for Romelu Lukaku with Marcus Rashford.
Liverpool manager Jurgen Klopp has recalled Mohamed Salah to his starting line-up having given the Egyptian brief rest in midweek against Porto.
— Liverpool FC (@LFC) March 10, 2018
Dejan Lovren has also been given the nod ahead of Joel Matip to play alongside Virgil van Dijk in defence, while Joe Gomez returns to the bench following his start against Porto.
Alex Oxlade-Chamberlain has been rewarded for his fine form of late, starting in midfield alongside Emre Can and James Milner with club captain Jordan Henderson on the bench.
The 170th league meeting between the two sides, both managers will know a win will give them a advantage in the race for second.
United go into the game two points ahead of their rivals who are unbeaten in their past five Premier League games, but a defeat for Liverpool could see them drop to fourth by the end of the weekend.
‘No Pogba, no party’ United fans to midfielder’s absence
With Pogba missing yet another big game for United, fans of the Red Devils were not too optimistic of their chances against Liverpool
No Pogba. No Martial. God give us this day.
— Ayomide Tayo (@AOT2) March 10, 2018
WHAT NO POGBA & MARTIAL?! https://t.co/qmTRkLaAht
— Faizal Faiz (@ffhasani) March 10, 2018
— Callum (@callumwashere) March 10, 2018
Gutted Pogba is out even on a poor day he is our most creative midfield player.
— mike the red #fbpe (@mikethered77) March 10, 2018
No martial n pogba today will be along 90+ mins for I
— Kill Monger♛💕® (@RobattoJR) March 10, 2018
Pogba and Martial not in the squad.. pic.twitter.com/90FxlXdkkh
— Ryan. 🔴 (@Vintage_Utd) March 10, 2018
Where is POGBA? 😧
— Sam ✨ (@JuanderfuI) March 10, 2018
No Pogba or Martial pic.twitter.com/AwiTNUd5va
— Steven (@TwoFootValencia) March 10, 2018