Both players picked up yellow cards in their remarkable 3-1 comeback win over Belgium in the quarter-finals, and by virtue of UEFA rules are suspended after two bookings in five games.
So having produced one of their best-ever performances to swat aside the world’s second-best ranked team, they will now have to recreate that magic without an important centre-back and their driving-force in midfield.
Manager Chris Coleman has instilled a wonderful team spirit and work ethic in the Wales camp. The team are a well-drilled XI, not a group of individuals, and are confident they can continue their momentum despite the suspensions.
“We will obviously miss them, but we have the strength and players playing at the top level so hopefully it won’t hamper us too much,” said centre-back James Chester, as reported by BBC Sport. “They have looked after themselves really well in training so whoever comes in I am sure they will do a good job.”
Most of the team picks itself for the clash with Cristiano Ronaldo and company in Lyon tonight, but who should fill in the void left by Davies and Ramsey?
Click the gallery above to see how Wales should line up this evening. But if you think you know better, head over to the Virgin Lineup Builder to create your XI!